Výsledky vyhledávání - "Sofie Mellberg"

Akademický článek

Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis.

Autor: Corban G Rivera, Sofie Mellberg, Lena Claesson-Welsh, Joel S Bader, Aleksander S Popel

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24887 (2011)

Angiogenesis is important for many physiological processes, diseases, and also regenerative medicine. Therapies that inhibit the vascular endothelial growth factor (VEGF) pathway have been used in the clinic for cancer and macular degeneration. In ca

Externí odkaz: https://doaj.org/article/bb3d730f2cbf4ad4ae340513a9e78327

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Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Autor: Erik G. Larsson, Sofie Mellberg, Hua Huang, Martin Teichert, Patrik Georgii-Hemming, Irina Alafuzoff, Hellmut G. Augustin, Lei Zhang, Agata Zieba, Grietje Molema, Anna Dimberg, Elise Langenkamp, Henriikka Salomäki, Fredrik Pontén, Theo F. J. Kraus, Per Henrik Edqvist, Lothar C. Dieterich, Tommie Olofsson, Ola Söderberg

Publikováno v: The Journal of Pathology. 228:378-390

Glioblastoma are aggressive astrocytic brain tumours characterized by microvascular proliferation and an abnormal vasculature, giving rise to brain oedema and increased patient morbidity. Here, we ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33fde730553af118dffa97c414ef07f0
https://doi.org/10.1002/path.4072

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FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin

Autor: Sofie Mellberg, Peetra U. Magnusson, Anna Dimberg, Lena Claesson-Welsh, Agneta Lukinius

Publikováno v: Blood. 110:4214-4222

The role of fibroblast growth factors (FGFs) in blood vessel formation has remained unclear. We used differentiating stem-cell cultures (embryoid bodies) and teratomas to show that FGF receptor-1 (FGFR-1) exerts a negative regulatory effect on endoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f80e3d1a9bc4008085864d690b198
https://doi.org/10.1182/blood-2007-01-067314

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Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer

Autor: Emma Rennel, Adam Ameur, Philippe Lassalle, Jan Komorowski, Pär Gerwins, Jakub Orzechowski Westholm, Michael J. Cross, Sofie Mellberg, Johan Botling, Ludvig Petersson, Anna Dimberg

Publikováno v: Experimental Cell Research. 313:1285-1294

An in vitro model of VEGF-A-induced angiogenesis was used to generate transcription profiles of human microvascular endothelial cells. Microarray analysis showed increased transcription of genes known to regulate angiogenesis, but also genes that pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53e008014a4d3ce56e6a6ae3c5b21a2
https://doi.org/10.1016/j.yexcr.2007.01.021

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Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

Autor: Lothar C, Dieterich, Sofie, Mellberg, Elise, Langenkamp, Lei, Zhang, Agata, Zieba, Henriikka, Salomäki, Martin, Teichert, Hua, Huang, Per-Henrik, Edqvist, Theo, Kraus, Hellmut G, Augustin, Tommie, Olofsson, Erik, Larsson, Ola, Söderberg, Grietje, Molema, Fredrik, Pontén, Patrik, Georgii-Hemming, Irina, Alafuzoff, Anna, Dimberg

Publikováno v: The Journal of pathology. 228(3)

Glioblastoma are aggressive astrocytic brain tumours characterized by microvascular proliferation and an abnormal vasculature, giving rise to brain oedema and increased patient morbidity. Here, we have characterized the transcriptome of tumour-associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c55ba9db2ebb8574c96a8150bd7b618
https://pubmed.ncbi.nlm.nih.gov/22786655

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Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

Autor: Emma Rennel, Anna Dimberg, Makoto Hayashi, Lena Claesson-Welsh, Per Lindahl, Fuad Bahram, Michael J. Cross, Erik Larsson, Sofie Mellberg, Adam Ameur, Jakub Orzechowski Westholm

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(5)

To define molecular events accompanying formation of the 3-dimensional (3D) vascular tube, we have characterized gene expression during vascular endothelial growth factor (VEGF)-induced tubular morphogenesis of endothelial cells. Microarray analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1674c931f483bd88960b09ad16ef92a
https://pubmed.ncbi.nlm.nih.gov/19136612

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VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

Autor: Carina Hellberg, Dietmar Vestweber, Heinz-Georg Belting, Makoto Hayashi, Sofie Mellberg, Markus Affolter, Gou Young Koh, Jeremy Adler, Simona Vertuani, Lars Holmgren, Xiujuan Li, Arindam Majumdar, Zuyue Sun, Anna Dimberg, Lena Claesson-Welsh, Sina Koch, Elisabetta Dejana, Gavin Thurston

Publikováno v: Nature communications
Nature Communications

Vascular endothelial growth factor (VEGF) guides the path of new vessel sprouts by inducing VEGF receptor-2 activity in the sprout tip. In the stalk cells of the sprout, VEGF receptor-2 activity is downregulated. Here, we show that VEGF receptor-2 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eddd3d12b4926d0195f5636bb7df98

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