Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Autor: Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele, Peter Vandenabeele

Publikováno v: Cell Death and Disease, Vol 11, Iss 11, Pp 1-15 (2020)

Abstract Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the

Externí odkaz: https://doaj.org/article/31ca415bc1864142a05906ae6e07ca1b

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Autor: Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, Peter Vandenabeele

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proc. Natl. Acad. Sci. U.S.A. 119:e2024508119 (2022)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis is widely believed to be crucial for epithelial cell death and shedding in the intestine, thereby shaping the overall architecture of the gastrointestinal tract, but also regulating tolerance induction, pinpointing a role of apoptosis intes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27592fe37266f1e32262a9b4b2f0f153
https://doi.org/10.1073/pnas.2024508119

MLKL deficiency in Braf

Autor: Sofie, Martens, Nozomi, Takahashi, Gillian, Blancke, Niels, Vandamme, Hanne, Verschuere, Tatyana, Divert, Marnik, Vuylsteke, Geert, Berx, Peter, Vandenabeele

Publikováno v: Cell deathdisease. 13(4)

Cancers acquire several capabilities to survive the multistep process in carcinogenesis. Resisting cell death is one of them. Silencing of the necroptosis initiator Ripk3 occurs in a wide variety of cancer types including melanoma. Little is known ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa947e2ca2961f1aceab496d152d466e
https://pubmed.ncbi.nlm.nih.gov/35422482

Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells

Autor: Sofie Martens, Peter Vandenabeele, Friederike Feldmann, Simone Fulda, Barbara Schenk

Publikováno v: Oncotarget
ONCOTARGET

// Friederike Feldmann 1, 2, 3 , Barbara Schenk 1 , Sofie Martens 4, 5 , Peter Vandenabeele 4, 5 and Simone Fulda 1, 2, 3 1 Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany 2 German Cancer Consortium (DK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b320172140a52e5129bcab3204a87a7a
https://doi.org/10.18632/oncotarget.19919

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Autor: Andreas Linkermann, Wulf Tonnus, Sam Hofmans, Jaewhan Song, Sofie Martens, Simone Fulda, Pieter Van der Veken, Nozomi Takahashi, Vera Goossens, Jan Hinrich Bräsen, Koen Augustyns, Peter Vandenabeele, Eun-Woo Lee, Manhyung Jeong, Jurgen Joossens, Friederike Feldmann

Publikováno v: Cell Death & Disease
CELL DEATH & DISEASE
Cell Death and Disease

Necroptosis contributes to the pathophysiology of several inflammatory, infectious and degenerative disorders. TNF-induced necroptosis involves activation of the receptor-interacting protein kinases 1 and 3 (RIPK1/3) in a necrosome complex, eventuall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3488e04f59e5f436e1bb784a17c8d2
https://doi.org/10.1038/cddis.2017.298