Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia:a NOPHO ALL2008 study

Autor: Kjeld Schmiegelow, Stefan N. Hansen, Birgitte Klug Albertsen, Riitta Niinimäki, Cecilie Utke Rank, Thomas Frandsen, Sofie Gottschalk Højfeldt, Susanna Ranta, Benjamin Wolthers, Mats Heyman, Line Stensig Lynggaard, Arja Harila-Saari, Louise Tram Henriksen, Kirsten Brunsvig Jarvis

Publikováno v: Lynggaard, L S, Rank, C U, Hansen, S N, Højfeldt, S G, Henriksen, L T, Jarvis, K B, Ranta, S, Niinimaki, R, Harila-Saari, A, Wolthers, B O, Frandsen, T L, Heyman, M, Schmiegelow, K & Albertsen, B K 2022, ' Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia : a NOPHO ALL2008 study ', Blood advances, vol. 6, no. 1, pp. 138-147 . https://doi.org/10.1182/bloodadvances.2021005631
Lynggaard, L S, Rank, C U, Hansen, S N, Gottschalk Højfeldt, S, Henriksen, L T, Jarvis, K B, Ranta, S, Niinimäki, R, Harila-Saari, A, Wolthers, B O, Frandsen, T L, Heyman, M, Schmiegelow, K & Albertsen, B K 2022, ' Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia : a NOPHO ALL2008 study ', Blood Advances, vol. 6, no. 1, pp. 138-147 . https://doi.org/10.1182/bloodadvances.2021005631
Blood Advances

Key Points Overall asparaginase-associated toxicity and relapse were not significantly associated with increased asparaginase enzyme activity levels.The risk of pancreatitis and osteonecrosis were significantly associated with increasing asparaginase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4940d618d5840f2b01d61d1e2c1f56
https://curis.ku.dk/ws/files/291358954/advancesadv2021005631.pdf

NOR-GRASPALL2016 (NCT03267030): Asparaginase Encapsulated in Erythrocytes (eryaspase) - a Promising Alternative to Peg-Asparaginase in Case of Hypersensitivity

Autor: Kjeld Schmiegelow, Sofie Gottschalk Højfeldt, Anne Kristine Lehmann, Line Stensig Lynggaard, Goda Vaitkeviciene, Cecilia Langenskiöld, Päivi M. Lähteenmäki, Kristi Lepik, Lisbeth Moeller, Birgitte Klug Albertsen

Publikováno v: Lynggaard, L S, Gottschalk Højfeldt, S, Møller, L N, Vaitkeviciene, G, Lepik, K, Cecilia, L, päivi, L, Lehmann, A K, Schmiegelow, K & Albertsen, BK 2020, ' NOR-GRASPALL2016 (NCT03267030): Asparaginase Encapsulated in Erythrocytes (eryaspase) – a Promising Alternative to Peg-Asparaginase in Case of Hypersensitivity ', Blood, vol. 136, no. Suppl 1, pp. 13-14 .
Aarhus University

Introduction: Asparaginase is an essential part of the treatment of acute lymphoblastic leukemia (ALL). Hypersensitivity occurred in 16.8% (clinical allergy (13.8%) or silent inactivation (3.0%)) of patients treated with pegylated asparaginase (PEG-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaceda14abe3257f810828e4b474407
https://doi.org/10.1182/blood-2020-139373

Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008

Autor: Ramneek Gupta, Goda Vaitkeviciene, Louise Tram Henriksen, Arja Harila-Saari, Jonas Abrahamsson, Sofie Gottschalk Højfeldt, Mats Heyman, Olafur G. Jonsson, Birgitte Klug Albertsen, Benjamin Ole Wolthers, Päivi M. Lähteenmäki, Kjeld Schmiegelow, Bendik Lund, Kaie Pruunsild, Morten Tulstrup

Publikováno v: Højfeldt, S G, Wolthers, B O, Tulstrup, M, Abrahamsson, J, Gupta, R, Harila-Saari, A, Heyman, M, Henriksen, L T, Jónsson, Ò G, Lähteenmäki, P M, Lund, B, Pruunsild, K, Vaitkeviciene, G, Schmiegelow, K, Albertsen, B K & Nordic Society of Paediatric Haematology Oncology (NOPHO) group 2019, ' Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008 ', British Journal of Haematology, vol. 184, no. 3, pp. 405-417 . https://doi.org/10.1111/bjh.15660

Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with PEG-asparaginase hypersensitivity ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8642b07760e58d10d2969cc9dd9d9357
https://pure.au.dk/portal/da/publications/genetic-predisposition-to-pegasparaginase-hypersensitivity-in-children-treated-according-to-nopho-all2008(00b999a3-c5ed-40ac-9cc5-9b4a15e2f4c6).html

Prolonged first-line PEG-asparaginase treatment in pediatric acute lymphoblastic leukemia in the NOPHO ALL2008 protocol-Pharmacokinetics and antibody formation

Autor: Sofie Gottschalk Højfeldt, Thomas Frandsen, Henrik Daa Schrøder, Birgitte Klug Albertsen, Peder Skov Wehner, Kjeld Schmiegelow, Louise Tram Henriksen

Publikováno v: Tram Henriksen, L, Gottschalk Højfeldt, S, Schmiegelow, K, Frandsen, T L, Skov Wehner, P, Schrøder, H, Klug Albertsen, B & Nordic Society of Pediatric Hematology and Oncology, NOPHO Group 2017, ' Prolonged first-line PEG-asparaginase treatment in pediatric acute lymphoblastic leukemia in the NOPHO ALL2008 protocol-Pharmacokinetics and antibody formation ', Pediatric Blood & Cancer, vol. 64, no. 12 . https://doi.org/10.1002/pbc.26686
Tram Henriksen, L, Gottschalk Højfeldt, S, Schmiegelow, K, Frandsen, T L, Skov Wehner, P, Schrøder, H, Klug Albertsen, B & Nordic Society of Pediatric Hematology and Oncology, NOPHO Group 2017, ' Prolonged first-line PEG-asparaginase treatment in pediatric acute lymphoblastic leukemia in the NOPHO ALL2008 protocol : Pharmacokinetics and antibody formation ', Pediatric Blood & Cancer, vol. 64, no. 12, e26686 . https://doi.org/10.1002/pbc.26686

BACKGROUND: As pegylated asparaginase is becoming the preferred first-line asparaginase preparation in the chemotherapy regimens of childhood acute lymphoblastic leukemia (ALL), there is a need to evaluate this treatment.METHODS: The aim of this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0473571c4b5054eda1ae0a46eebd0549
https://pubmed.ncbi.nlm.nih.gov/28660740

NOR-GRASPALL 2016: Asparaginase encapsulated in erythrocytes – a promising alternative to PEG-asparaginase in case of hypersensitivity. Line Stensig Lynggaard

Autor: Line Stensig Lynggaard, Sofie Gottschalk Højfeldt, Goda Vaitkeviciene, Langenskiöld Cecilia, Anne Kirstine Lehmann, lähteenmäki päivi, Kristi Lepik, Kjeld Schmiegelow, Birgitte Klug Albertsen

Publikováno v: Aarhus University
Lynggaard, L S, Gottschalk Højfeldt, S, Vaitkeviciene, G, Cecilia, L, Lehmann, A K, päivi, L, Lepik, K, Schmiegelow, K & Albertsen, BK 2019, ' NOR-GRASPALL 2016: Asparaginase encapsulated in erythrocytes – a promising alternative to PEG-asparaginase in case of hypersensitivity. Line Stensig Lynggaard ', NOPHO Annual Meeting, Aalborg, Denmark, 04/05/2019-07/05/2019 .

NOR-GRASPALL 2016: Asparaginase encapsulated in erythrocytes – a promising alternative to PEG-asparaginase in case of hypersensitivity. Line Stensig Lynggaard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b4a1b653272a3487e38e8aa6129e832
https://pure.au.dk/portal/en/publications/norgraspall-2016-asparaginase-encapsulated-in-erythrocytes--a-promising-alternative-to-pegasparaginase-in-case-of-hypersensitivity-line-stensig-lynggaard(ab7828ad-7024-48e8-a911-5f0535b9c334).html