Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sofie De Groef"'
Autor:
Sofie De Groef, Melanie Ribeiro Lopes, Mattias Winant, Emily Rosschaert, Tom Wilms, Lenz Bolckmans, Federica Calevro, Patrick Callaerts
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Sex is an important variable in biology. Notable differences have been observed between male and female Drosophila in regulation of metabolism, in response to nutritional challenges, and in phenotypes relevant for obesity and metabolic disor
Externí odkaz:
https://doaj.org/article/61970a0283b34c05a0e669fe707aa453
Autor:
Mattias Winant, Kurt Buhler, Jason Clements, Sofie De Groef, Korneel Hens, Veerle Vulsteke, Patrick Callaerts
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010380 (2022)
Drosophila Insulin-Producing Cells (IPCs) are the main production site of the Drosophila Insulin-like peptides or dilps which have key roles in regulating growth, development, reproduction, lifespan and metabolism. To better understand the signalling
Externí odkaz:
https://doaj.org/article/eb8ac901c4b44f1dbb330637b196446d
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 33 (2021)
Obesity is a chronic disease affecting millions of people worldwide. The fruit fly (Drosophila melanogaster) is an interesting research model to study metabolic and transcriptomic responses to obesogenic diets. However, the sex-specific differences i
Externí odkaz:
https://doaj.org/article/ff7832d37afa45abba265b7b4c061e58
Publikováno v:
Biomolecules
Biomolecules, MDPI, 2022, 12 (1), pp.33. ⟨10.3390/biom12010033⟩
Biomolecules, Vol 12, Iss 33, p 33 (2022)
Biomolecules; Volume 12; Issue 1; Pages: 33
Biomolecules, MDPI, 2022, 12 (1), pp.33. ⟨10.3390/biom12010033⟩
Biomolecules, Vol 12, Iss 33, p 33 (2022)
Biomolecules; Volume 12; Issue 1; Pages: 33
Obesity is a chronic disease affecting millions of people worldwide. The fruit fly (Drosophila melanogaster) is an interesting research model to study metabolic and transcriptomic responses to obesogenic diets. However, the sex-specific differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9118c083707a29b7c932a7942036b58c
https://hal.inrae.fr/hal-03521337
https://hal.inrae.fr/hal-03521337
Autor:
Gérard Gradwohl, Jorge Ferrer, Marie Lemper, Christoffer Nord, Paola Bonfanti, Michael S. German, Ruth Shemer, Sofie De Groef, Geert Stangé, Fong Cheng Pan, Harry Heimberg, Luc Bouwens, Luc Baeyens, Ulf Ahlgren, Doris A. Stoffers, Gunter Leuckx, Mark Van de Casteele, Guoqiang Gu, Yuval Dor, David W. Scheel, Christopher V.E. Wright
Publikováno v:
Nature biotechnology, vol 38, iss 3
Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic
Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice
Autor:
Nico De Leu, Yves Heremans, Yuval Dor, Gunter Leuckx, Ciro Salinno, Naomi Van Gassen, Eli Keshet, Willem Staels, Martine Cools, Harry Heimberg, Sofie De Groef
Publikováno v:
Diabetologia. 60:1051-1056
AIMS/HYPOTHESIS: Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of th
Autor:
Harry Heimberg, Gunter Leuckx, Eelco J.P. de Koning, Yves Heremans, Yannick Verdonck, Carlo Heirman, Nico De Leu, Willem Staels, Kris Thielemans, Sofie De Groef, Luc Baeyens, Conny Gysemans
Publikováno v:
Diabetologia
Diabetologia, 61(8), 1804-1810. Springer Verlag GmbH
Diabetologia, 61(8), 1804-1810
Diabetologia, 61(8), 1804-1810. Springer Verlag GmbH
Diabetologia, 61(8), 1804-1810
AIMS/HYPOTHESIS: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularisation to improve engraftment has been attempted through virus-based delivery of angiogenic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b100c72cd3e3cada71a31757b7068e7
https://doi.org/10.1007/s00125-018-4646-7
https://doi.org/10.1007/s00125-018-4646-7
Autor:
Mark Van de Casteele, Jo A. Van Ginderachter, Harry Heimberg, Willem Staels, Geert A. Martens, Nico De Leu, Ying Cai, Gunter Leuckx, Violette Coppens, Eva Van Overmeire, Bart Legein, Yixing Yuchi, Sofie De Groef
Publikováno v:
Diabetes
Identifying pathways for beta cell generation is essential for cell therapy in diabetes. Here we investigate the potential of 17β-estradiol (E2) and estrogen receptor (ER) signaling for stimulating beta cell generation during embryonic development a
Autor:
Nico De Leu, Mark Van de Casteele, Benoit Stijlemans, Patrick De Baetselier, Eva Van Overmeire, Jo A. Van Ginderachter, Harry Heimberg, Yves Heremans, Ying Cai, Conny Gysemans, Naomi Van Gassen, Sofie De Groef, Yvon Elkrim, Gunter Leuckx
Publikováno v:
European Journal of Immunology. 45:1482-1493
Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β-cell neogenesis and proliferation. Macrophages (MΦs) were recently shown to promote β-cell proliferation after PDL, but they remain poorly characterized. W
AIMS/HYPOTHESIS: When the beta cell mass or function declines beyond a critical point, hyperglycaemia arises. Little is known about the potential pathways involved in beta cell rescue. As two cytokines, epidermal growth factor (EGF) and ciliary neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94063121f0311eb4c845162a8a0d62a2
https://doi.org/10.1007/s00125-016-4023-3
https://doi.org/10.1007/s00125-016-4023-3