Výsledky vyhledávání - "Sofie Carmans"

Akademický článek

Glycine and glycine receptor signalling in non-neuronal cells

Autor: Jimmy Van Den Eynden, Sheen SahebAli, Nikki Horwood, Sofie Carmans, Bert Brône, Niels Hellings, Paul Steels, Robert J Harvey, Jean-Michel Rigo

Publikováno v: Frontiers in Molecular Neuroscience, Vol 2 (2009)

Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types. Modulatory effec

Externí odkaz: https://doaj.org/article/b776a0bd15394b68b5191da1e8035673

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A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

Autor: Joris Winderickx, Joke Verelst, Nick Geukens, Mohamed Laghmouchi, Elien De Smidt, Erik Stoops, Debby Thomas, Eugeen Vanmechelen, Joelle Rosseels, Maria Bjerke, Luc Buée, Dorien Vliegen, Sofie Carmans, Sofie Molenberghs, Vanessa Franssens, Sabiha Eddarkaoui, Sebastiaan Engelborghs, Cindy Francois

Publikováno v: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences, 2020, 7, pp.48. ⟨10.3389/fmolb.2020.00048⟩
Frontiers in Molecular Biosciences, Frontiers Media, 2020, 7, pp.48. ⟨10.3389/fmolb.2020.00048⟩

As human Tau undergoes pathologically relevant post-translational modifications when expressed in yeast, the use of humanized yeast models for the generation of novel Tau monoclonal antibodies has previously been proven to be successful. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e5991c924cc37860ef1475c6597e30
http://europepmc.org/articles/PMC7136581

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Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models

Publikováno v: Glia. 66:492-504

Chronic inflammation represents a central component in the pathogenesis of Alzheimer's disease (AD). Recent work suggests that breaking immune tolerance by Programmed cell Death-1 (PD1) checkpoint inhibition produces an IFN-γ-dependent systemic immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a90df3d92064983926f01868f13e0e3
https://doi.org/10.1002/glia.23260

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Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Autor: Pasi Miettinen, Ellen Ytebrouck, Bart Roucourt, Heikki Tanila, Sofie Carmans, Reyhaneh Naderi, Hennariikka Koivisto

Publikováno v: Behavioural Brain Research

This study assessed the development of motor deficits in female hTau.P301S transgenic mice from 1.5 to 5.5 months of age. The test battery included clasping reflex, grid hanging, Rotarod test, spontaneous explorative activity, Catwalk gait analysis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62325e43acebafc32b52df2feafb28bb

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Systemic treatment with the inhibitory neurotransmitter gamma-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses

Autor: Kristof Thewissen, Niels Hellings, Piet Stinissen, Helena Slaets, Jerome J. A. Hendriks, Sofie Carmans, Jean-Michel Rigo

Publikováno v: Journal of Neuroimmunology. 255:45-53

Transcriptomic and proteomic analyses of multiple sclerosis (MS) lesions indicate alterations in the gamma-aminobutyric acid (GABA) inhibitory system, suggesting its involvement in the disease process. To further elucidate the role of GABA in central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c45ffadd17f16fc5617fb91745820b
https://doi.org/10.1016/j.jneuroim.2012.11.001

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The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters

Autor: Jimmy Van den Eynden, Kristof Thewissen, Niels Hellings, Jerome J. A. Hendriks, Piet Stinissen, Sofie Carmans, Jean-Michel Rigo

Glycine, an important inhibitory neurotransmitter in the mammalian central nervous system (CNS), has been shown to modulate peripheral immune cell responses. In that respect, glycine levels are increased in several neuroinflammatory disorders, like a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce4126e144d6628551dcc6d0be7bb3
http://hdl.handle.net/1942/10704

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Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages

Autor: Niels Hellings, Jerome J. A. Hendriks, Christine D. Dijkstra, Sofie Carmans, Helena Slaets, Piet Stinissen, Helga E. de Vries

Publikováno v: Journal of Neuroimmunology, 204(1-2), 52-57. Elsevier
Hendriks, J J A, Slaets, H, Carmans, S, de Vries, H E, Dijkstra, C D, Stinissen, P & Hellings, N 2008, ' Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages ', Journal of Neuroimmunology, vol. 204, no. 1-2, pp. 52-57 . https://doi.org/10.1016/j.jneuroim.2008.07.015

Leukemia inhibitory factor (LIF) promotes survival of glial cells and neurons during autoimmune and injury responses in the central nervous system (CNS). While various studies indicate that LIF also modulates ongoing inflammatory responses, data on u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed27a30d328b1a070a70998425fdda9
https://research.vumc.nl/en/publications/07b19edb-1676-403f-9329-f502e176918b

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