Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sofie, Lust"'
Autor:
Ans Rombout, Basile Stamatopoulos, Laurence Lagneaux, Sofie Lust, Fritz Offner, Evelien Naessens, Hanne Vanderstraeten, Bruno Verhasselt, Jan Philippé
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121526 (2015)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evol
Externí odkaz:
https://doaj.org/article/6226959c33774814af0730e377f1757a
Publikováno v:
British Journal of Cancer
Background: The B-cell receptor (BCR) has a key role in the cross-talk between chronic lymphocytic leukaemia (CLL) cells and the tissue microenvironment, which favours disease progression by promoting proliferation and drug resistance. In vitro studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5088464458ea5afe18188111adea8c
https://doi.org/10.1038/bjc.2016.35
https://doi.org/10.1038/bjc.2016.35
Autor:
Heleen Van Melckebeke, Karen Leroy, Barbara Vanhoecke, Jean-Philippe Jais, Sofie Lust, Fabrice Jardin, Josette Brière, Jerina Boelens, Fritz Offner, Jan Philippé, Marc Bracke, Ilse M. Beck
Publikováno v:
Leukemia Research. 37:3-8
The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581638465ea36e7d3ac09e77151ba852
https://doi.org/10.1016/j.leukres.2012.08.017
https://doi.org/10.1016/j.leukres.2012.08.017
Autor:
Marc Bracke, Mireille Van Gele, Lara Derycke, Femke Van Bockstaele, Fritz Offner, Ann Janssens, Jan Philippé, Barbara Vanhoecke, Sofie Lust, Jerina Boelens
Publikováno v:
Leukemia Research. 33:1335-1343
There is resurgent interest in glucocorticoids (GCs) in the treatment of poor prognosis chronic lymphocytic leukemia (CLL). Little is known however on how GCs induce apoptosis in CLL. Methylprednisolone (MP) induces apoptosis in ZAP-70 positive CLL m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ba63c81dfe9d7d627f268946313ad
https://doi.org/10.1016/j.leukres.2009.02.022
https://doi.org/10.1016/j.leukres.2009.02.022
Autor:
Lynn Vanhaecke, D. Marzin, Sofie Lust, Willy Verstraete, Lara Derycke, Frank Le Curieux, Marc Bracke
Publikováno v:
Toxicology Letters. 178:61-69
7-Hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (PhIP-M1) is a newly identified intestinal microbial metabolite from the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfae28f6e6645b1eae0016425853b252
https://doi.org/10.1016/j.toxlet.2008.02.004
https://doi.org/10.1016/j.toxlet.2008.02.004
Publikováno v:
Molecular Nutrition & Food Research. 49:844-850
B-chronic lymphocytic leukemia (B-CLL) is an indolent lymphoid malignancy with variable prognosis. Adverse prognostic factors comprise treatment resistance, cytogenetics (11q- and 17p-), the presence of unmutated Ig genes, and the more comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200c44884235f738da00bf3d33384ea2
https://doi.org/10.1002/mnfr.200500045
https://doi.org/10.1002/mnfr.200500045
Autor:
Michael R. Olson, Ioanna Papandreou, Fritz Offner, Donna M. Bouley, Heleen Van Melckebeke, Nicholas C. Denko, David E. Solow-Cordero, Arvin B. Tam, Maho Niwa, Albert C. Koong, Sofie Lust
Publikováno v:
Blood. 117(4)
Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and hematologic malignancies, including multiple myeloma (MM). Here, we report the identification of STF-083010, a novel small-molecule inhibitor of Ire1. STF-08301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7a914869f7145922b3827edb425133
https://pubmed.ncbi.nlm.nih.gov/21081713
https://pubmed.ncbi.nlm.nih.gov/21081713
Publikováno v:
Molecular nutritionfood research. 54(6)
We explored the mechanism of cell death of the polymethoxyflavone tangeretin (TAN) in K562 breakpoint cluster region-abelson murine leukemia (Bcr-Abl+) cells. Flow cytometric analysis showed that TAN arrested the cells in the G(2)/M phase and stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab57c14a7675271de88faad7049dbeb
https://pubmed.ncbi.nlm.nih.gov/20077418
https://pubmed.ncbi.nlm.nih.gov/20077418
Autor:
Sofie, Lust, Barbara, Vanhoecke, Mireille, VAN Gele, Jerina, Boelens, Heleen, VAN Melckebeke, Mary, Kaileh, Wim, Vanden Berghe, Guy, Haegeman, Jan, Philippé, Marc, Bracke, Fritz, Offner
Publikováno v:
Anticancer Res
BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. A novel approach to overcome chemotherapy resistance may be targeting the endoplasmic reticulum (ER). PATIENTS AND
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7042a9ce927ba688116acee0608cd7cd
https://pubmed.ncbi.nlm.nih.gov/19846911
https://pubmed.ncbi.nlm.nih.gov/19846911
Publikováno v:
Anticancer research. 29(2)
Chronic lymphocytic leukaemia remains the most common adult leukaemia in Western countries. In this review we tried to give an overview of the important prognostic markers and the developments in this field. We also reflected about the accumulative c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14f468a89250d1bdd6bbe2e9f657ccc2
https://pubmed.ncbi.nlm.nih.gov/19331210
https://pubmed.ncbi.nlm.nih.gov/19331210