Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sofiane Y. Mersaoui"'
Autor:
Franciele Faccio Busatto, Sofiane Y. Mersaoui, Yilun Sun, Yves Pommier, Jean-Yves Masson, Jenifer Saffi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Topoisomerase 2 (TOP2) inhibitors are drugs widely used in the treatment of different types of cancer. Processing of their induced-lesions create double-strand breaks (DSBs) in the DNA, which is the main toxic mechanism of topoisomerase inhibitors to
Externí odkaz:
https://doaj.org/article/45e3879ae15d4f908ae61d3a9d47acfa
Publikováno v:
Microbial Cell, Vol 2, Iss 10, Pp 394-405 (2015)
In budding yeast, telomerase and the Cdc13p protein are two key players acting to ensure telomere stability. In the absence of telomerase, cells eventually enter a growth arrest which only few can overcome via a conserved process; such cells are call
Externí odkaz:
https://doaj.org/article/ee983e7de9ac41b29d85f956e75ab424
Autor:
Nicole L Batenburg, Sofiane Y Mersaoui, John R Walker, Yan Coulombe, Ian Hammond-Martel, Hugo Wurtele, Jean-Yves Masson, Xu-Dong Zhu
Publikováno v:
Nucleic Acids Research
Cockayne syndrome group B (CSB) protein has been implicated in the repair of a variety of DNA lesions that induce replication stress. However, little is known about its role at stalled replication forks. Here, we report that CSB is recruited to stall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cf02a1ee193c3e69f0fa61f05a907b
https://doi.org/10.1093/nar/gkab1173
https://doi.org/10.1093/nar/gkab1173
Autor:
El Bachir Affar, Sofiane Y Mersaoui, Franciele F. Busatto, Daryl A. Ronato, Stéphane Richard, Jean-Yves Masson
Publikováno v:
Trends in Biochemical Sciences. 45:779-793
DNA double-strand break (DSB) resection, once thought to be a simple enzymatic process, is emerging as a highly complex series of coordinated activities required to maintain genome integrity. Progress in cell biology, biochemistry, and genetics has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780735dc7bbca4cd2de657208298c351
https://doi.org/10.1016/j.tibs.2020.05.003
https://doi.org/10.1016/j.tibs.2020.05.003
Autor:
Sofiane Y. Mersaoui, Cynthia Guilbert, Hsiang Chou, Christelle Douillet, D. Scott Bohle, Miroslav Stýblo, Stéphane Richard, Koren K. Mann
Publikováno v:
Archives of toxicology. 96(5)
Arsenic toxicity is a global concern to human health causing increased incidences of cancer, bronchopulmonary, and cardiovascular diseases. In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b17b968f849893b79f9354eff8c4400
https://pubmed.ncbi.nlm.nih.gov/35244730
https://pubmed.ncbi.nlm.nih.gov/35244730
Publikováno v:
Journal of Visualized Experiments.
The study of the DNA damage response (DDR) is a complex and essential field, which has only become more important due to the use of DDR-targeting drugs for cancer treatment. These targets are poly(ADP-ribose) polymerases (PARPs), which initiate vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b74ce9e80287303ccc085506857444
https://doi.org/10.3791/62553
https://doi.org/10.3791/62553
Autor:
Zhenbao Yu, Yan Coulombe, Jean-Yves Masson, Laure Guitton-Sert, Stéphane Richard, Sofiane Y Mersaoui, Jingwen Song
Publikováno v:
Nar Cancer
R-loops are three-stranded structures consisting of a DNA/RNA hybrid and a displaced DNA strand. The regulatory factors required to process this fundamental genetic structure near double-strand DNA breaks (DSBs) are not well understood. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99edc54398b92a2820004cec8e1aa4fe
https://pubmed.ncbi.nlm.nih.gov/33015627
https://pubmed.ncbi.nlm.nih.gov/33015627
Publikováno v:
Nucleic Acids Research
Cdc13 is an essential protein involved in telomere maintenance and chromosome capping. Individual domain analyses on Cdc13 suggest the presence of four distinct OB-fold domains and one recruitment domain. However, it remained unclear how these sub-do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054b2e7ffdbb870030868855bffdc7e0
https://doi.org/10.1093/nar/gky085
https://doi.org/10.1093/nar/gky085
Publikováno v:
Cancer Cell. 36:3-5
In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the author
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3b76fdd9c866a8a6e270b07395ed7b
https://doi.org/10.1016/j.ccell.2019.06.004
https://doi.org/10.1016/j.ccell.2019.06.004
Autor:
Jean-Yves Masson, Stéphane Richard, Martin Karam, Zhenbao Yu, Franciele F. Busatto, Yan Coulombe, Sofiane Y Mersaoui
Publikováno v:
The EMBO Journal
Aberrant transcription‐associated RNA:DNA hybrid (R‐loop) formation often causes catastrophic conflicts during replication, resulting in DNA double‐strand breaks and genomic instability. Preventing such conflicts requires hybrid dissolution by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7229c97ec132b6cb11af43755322441
https://doi.org/10.15252/embj.2018100986
https://doi.org/10.15252/embj.2018100986