Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.

Autor: Sofia Winslow, Anica Scholz, Peter Rappl, Thilo F Brauß, Christina Mertens, Michaela Jung, Andreas Weigert, Bernhard Brüne, Tobias Schmid

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0209694 (2019)

While aberrant cells are routinely recognized and removed by immune cells, tumors eventually escape innate immune responses. Infiltrating immune cells are even corrupted by the tumor to acquire a tumor-supporting phenotype. In line, tumor-associated

Externí odkaz: https://doaj.org/article/c171fb79eb7740a9b8daa89a0fef07c7

Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells.

Autor: Chandrani Achari, Sofia Winslow, Christer Larsson

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130300 (2015)

Identification of targets for apoptosis induction is important to provide novel therapeutic approaches in breast cancer. Our earlier studies showed that down regulation of protein kinase C δ (PKCδ) induces death in breast cancer cells. In this stud

Externí odkaz: https://doaj.org/article/f9e4098f82eb464e8e736d0babafd944

Late Breaking Abstract - The inflammasome cluster is linked with airway NETosis in COPD

Autor: Lina Odqvist, Alix Berton, Thomas Southworth, Andrew Higham, Madeleine Ingelsten, Johan Jirholt, Sofia Lundin, Dave Singh, Magdalena Rhedin, Hoda Sharifian, Sofia Winslow, Zala Jevnikar

Publikováno v: Mechanisms of lung injury and repair.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bbbb5287f1bafdd8e2e975a5f021255
https://doi.org/10.1183/13993003.congress-2021.oa2702

Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and

Autor: Sofia, Winslow, Lina, Odqvist, Sarah, Diver, Rebecca, Riise, Suado, Abdillahi, Cecilia, Wingren, Helena, Lindmark, Annika, Wellner, Sofia, Lundin, Linda, Yrlid, Elisabeth, Ax, Ratko, Djukanovic, Sriram, Sridhar, Andrew, Higham, Dave, Singh, Thomas, Southworth, Christopher E, Brightling, Henric K, Olsson, Zala, Jevnikar

Publikováno v: The European respiratory journal. 58(4)

Interleukin (IL)-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6TS pathway activation r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::331d32bbd668b287f6439c78ea65b491
https://pubmed.ncbi.nlm.nih.gov/34649972

The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma

Autor: Bernhard Brüne, Anja Urbschat, Andreas Weigert, Klaus Zwicker, Christina Mertens, Rebekka Bauer, Arnaud Huard, Julia K. Meier, Matthias Schnetz, Frederik Roos, Sofia Winslow, Michaela Jung, Claudia Rehwald, Patrick C. Baer

Publikováno v: Rehwald, C, Schnetz, M, Urbschat, A, Mertens, C, Meier, J K, Bauer, R, Baer, P, Winslow, S, Roos, F C, Zwicker, K, Huard, A, Weigert, A, Brüne, B & Jung, M 2020, ' The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma ', British Journal of Cancer, vol. 122, no. 3, pp. 421-433 . https://doi.org/10.1038/s41416-019-0655-7
British Journal of Cancer

Background We aimed at clarifying the role of lipocalin-2 (LCN-2) in clear-cell renal cell carcinoma (ccRCC). Since LCN-2 was recently identified as a novel iron transporter, we explored its iron load as a decisive factor in conferring its biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d501a31f2d05f2974674562b6b2fa251
https://publica.fraunhofer.de/handle/publica/262870