Výsledky vyhledávání - "Sofia Westbom Fremer"

Akademický článek

SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery

Autor: Maria Bååth, Sofia Westbom-Fremer, Laura Martin de la Fuente, Anna Ebbesson, Juliette Davis, Susanne Malander, Anna Måsbäck, Päivi Kannisto, Ingrid Hedenfalk

Publikováno v: Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)

The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in

Externí odkaz: https://doaj.org/article/6bd8032c7fe94d93b758c4fa7e5ea4fa

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A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated With Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor) A Report of 22 Cases

Publikováno v: Am J Surg Pathol
American Journal of Surgical Pathology, 45(8), 1061-1074. LIPPINCOTT WILLIAMS & WILKINS

We describe 22 examples of a novel, usually paratubal, adnexal tumor associated with Peutz-Jeghers syndrome in nearly 50% of cases that harbored STK11 alterations in all tested (n=21). The patients ranged from 17 to 66 (median 39) years and the tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77ddd19c279757e2ecb9b580442ac08
https://doi.org/10.1097/pas.0000000000001677

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Akademický článek

Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma

Autor: Nicolai Skovbjerg Arildsen, Jenny-Maria Jönsson, Katarina Bartuma, Anna Ebbesson, Sofia Westbom-Fremer, Anna Måsbäck, Susanne Malander, Mef Nilbert, Ingrid A. Hedenfalk

Publikováno v: Frontiers in Oncology, Vol 7 (2017)

ObjectiveOvarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events

Externí odkaz: https://doaj.org/article/07791a094ade4600acdf89a8b1810bfb

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High density of stroma-localized CD11c-positive macrophages is associated with longer overall survival in high-grade serous ovarian cancer

Autor: Arne Östman, Joseph W. Carlson, Artur Mezheyeuski, Charlotte Rolny, Susanne Malander, Sara Corvigno, Sofia Westbom-Fremer, Hanna Dahlstrand, Päivi Kannisto, Josefin Fernebro, Ingrid Hedenfalk, Laura Martin de la Fuente, Elisabeth Åvall-Lundqvist

Publikováno v: Gynecologic Oncology. 159:860-868

Objective Pre-clinical studies have identified marker- and tumor compartment-defined functionally distinct macrophage subsets. Our study analyzes marker-defined macrophage subsets in different tumor compartments of high-grade serous ovarian cancer (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f819778d31f7fa9536af04caa9255ab6
https://doi.org/10.1016/j.ygyno.2020.09.041

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MET Expression and Cancer Stem Cell Networks Impact Outcome in High-Grade Serous Ovarian Cancer

Autor: Maria Bååth, Jenny-Maria Jönsson, Sofia Westbom Fremer, Laura Martín de la Fuente, Lena Tran, Susanne Malander, Päivi Kannisto, Anna Måsbäck, Gabriella Honeth, Ingrid Hedenfalk

Publikováno v: Genes
Volume 12
Issue 5
Genes, Vol 12, Iss 742, p 742 (2021)

Overexpression of the receptor tyrosine kinase MET has been linked to poor survival in several cancer types, and MET has been suggested to interact with stem cell networks. In vitro studies have further suggested a possible benefit of a combined trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3787404883b7dc8cbcfd1104f5ee7c3e
https://pubmed.ncbi.nlm.nih.gov/34069138

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PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability

Autor: Dijana Djureinovic, Patrick Micke, Martin Isaksson-Mettävainio, Hans Brunnström, Anna Johansson, Max Backman, Sofia Westbom-Fremer, Annika Patthey, Miklos Gulyas

Publikováno v: Modern Pathology. 30:1411-1421

Assessment of programmed cell death ligand 1 (PD-L1) immunohistochemical staining is used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint inhibitors in lung adenocarcinomas and squamous cell carcinomas. This study aimed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd448e36dc2a41772039d382074e694
https://doi.org/10.1038/modpathol.2017.59

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Validation of a Mitotic Index Cutoff as a Prognostic Marker in Undifferentiated Uterine Sarcomas

Autor: Anna Måsbäck, Jonas Selling, Mehran Ghaderi, Tone Skeie-Jensen, Joseph W. Carlson, Ben Davidson, Sofia Westbom-Fremer, Elizabeth H. Cheek, Sofia Josefson, John K. Schoolmeester, Elin Hardell, Debra A. Bell

Publikováno v: American Journal of Surgical Pathology. 41:1231-1237

Undifferentiated uterine sarcomas (UUS) are a heterogenous group of high-grade mesenchymal tumors. Although these tumors are highly aggressive, a subset of patients may experience long-term survival. These tumors have previously been divided morpholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d68f21da0fd23de135688fe7b17d07
https://doi.org/10.1097/pas.0000000000000894

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PD-1/PD-L1 expression and tumor-infiltrating lymphocytes are prognostically favorable in advanced high-grade serous ovarian carcinoma

Autor: Laura Martin de la Fuente, Sofia Westbom-Fremer, Susanne Malander, Linda Werner Hartman, Ingrid Hedenfalk, Anna Måsbäck, Päivi Kannisto, Nicolai Skovbjerg Arildsen

Publikováno v: Virchows Archiv

The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, and development of predictive biomarkers is needed. The main focus has been on tumor cell PD-L1 expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2eeb6ba47c937d855c7317c3b4f171
https://pubmed.ncbi.nlm.nih.gov/31980961

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Abstract B12: Targeted sequencing of ovarian clear cell carcinomas reveals intertumor heterogeneity and distinct clustering related to mutational load

Autor: Jenny-Maria Jönsson, Anna Ebbesson, Anna Måsbäck, Susanne Malander, Nicolai Skovbjerg Arildsen, Mef Nilbert, Ingrid Hedenfalk, Sofia Westbom-Fremer

Publikováno v: Clinical Cancer Research. 22:B12-B12

Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype. Despite relatively clear clinical features, OCCCs can be difficult to distinguish morphologically from other epithelial ovarian cancers. OCCC gene expression s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24e4f16aa11509df9709cd9b0380edf5
https://doi.org/10.1158/1557-3265.ovca15-b12

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