Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sofia Thomaidou"'
Autor:
Bruno Blanchi, Marion Taurand, Claire Colace, Sofia Thomaidou, Charlotte Audeoud, Federica Fantuzzi, Toshiaki Sawatani, Sevda Gheibi, Joan Sabadell-Basallote, Fransje W.J. Boot, Thibault Chantier, Aline Piet, Charlotte Cavanihac, Marion Pilette, Adélie Balguerie, Hamza Olleik, Françoise Carlotti, Miriam Ejarque, Malin Fex, Hindrik Mulder, Miriam Cnop, Decio L. Eizirik, Ouardane Jouannot, Anne-Lise Gaffuri, Paul Czernichow, Arnaud Zaldumbide, Raphaël Scharfmann, Philippe Ravassard
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101772- (2023)
Objectives: Readily accessible human pancreatic beta cells that are functionally close to primary adult beta cells are a crucial model to better understand human beta cell physiology and develop new treatments for diabetes. We here report the charact
Externí odkaz:
https://doaj.org/article/2150f4f22a72439bb1a63dbdb430ec0a
Autor:
Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and th
Externí odkaz:
https://doaj.org/article/218bb0ec35764b7b94f829cfe9e42916
Autor:
René van Tienhoven, Maria J. L. Kracht, Arno R. van der Slik, Sofia Thomaidou, Anouk H. G. Wolters, Ben N. G. Giepmans, Juan Pablo Romero Riojas, Michael S. Nelson, Françoise Carlotti, Eelco J. P. de Koning, Rob C. Hoeben, Arnaud Zaldumbide, Bart O. Roep
Publikováno v:
Diabetologia, 66(5), 884-896. SPRINGER
Aims/hypothesis Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. Methods Alternative splicing of insulin pre-mRNA was determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078ebd9b4dbdb4aa6a72a2035c08148
http://hdl.handle.net/1887/3619412
http://hdl.handle.net/1887/3619412
Autor:
Florian Szymczak, Maria Inês Alvelos, Sandra Marín-Cañas, Ângela Castela, Stéphane Demine, Maikel Luis Colli, Anne Op de Beeck, Sofia Thomaidou, Lorella Marselli, Arnaud Zaldumbide, Piero Marchetti, Décio L. Eizirik
Publikováno v:
Science advances.
IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation to the immune system. We observ
Autor:
Arnaud Zaldumbide, Françoise Carlotti, Bart O. Roep, Sandra Laban, Arno R. van der Slik, Maria J L Kracht, Rob C. Hoeben, Sofia Thomaidou, Eelco J.P. de Koning
Publikováno v:
Diabetes
Diabetes, 69(4), 670-680. American Diabetes Association Inc.
Diabetes, 69(4), 670-680. AMER DIABETES ASSOC
Diabetes, 69(4), 670-680. American Diabetes Association Inc.
Diabetes, 69(4), 670-680. AMER DIABETES ASSOC
The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)-mediated beta -cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the si
Autor:
Hailiang Mei, Jasper Boom, Françoise Carlotti, Arno R. van der Slik, Bobby P. C. Koeleman, Roderick C. Slieker, Arnaud Zaldumbide, Bart O. Roep, Rob C. Hoeben, Leen M 't Hart, Sofia Thomaidou, Flip Mulder, Amadeo Munoz-Garcia
Publikováno v:
Diabetes, 70(10), 2299-2312. American Diabetes Association Inc.
Diabetes, 70(10), 2299-2312. AMER DIABETES ASSOC
Thomaidou, S, Slieker, R C, van der Slik, A R, Boom, J, Mulder, F, Munoz-Garcia, A, 't Hart, L M, Koeleman, B, Carlotti, F, Hoeben, R C, Roep, B O, Mei, H & Zaldumbide, A 2021, ' Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape ', Diabetes, vol. 70, no. 10, pp. 2299-2312 . https://doi.org/10.2337/db20-1122
Diabetes
Diabetes, 70(10), 2299-2312. AMER DIABETES ASSOC
Thomaidou, S, Slieker, R C, van der Slik, A R, Boom, J, Mulder, F, Munoz-Garcia, A, 't Hart, L M, Koeleman, B, Carlotti, F, Hoeben, R C, Roep, B O, Mei, H & Zaldumbide, A 2021, ' Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape ', Diabetes, vol. 70, no. 10, pp. 2299-2312 . https://doi.org/10.2337/db20-1122
Diabetes
Type 1 diabetes is an autoimmune disease characterized by autoreactive T-cell mediated destruction of the insulin-producing pancreatic beta-cells. Increasing evidence suggest that the beta-cells themselves contribute to their own destruction by gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed89496a543e5197ab99f57fa3c8d78e
https://research.vumc.nl/en/publications/8396ddc5-0871-4a2c-abb1-9bdf10d2873e
https://research.vumc.nl/en/publications/8396ddc5-0871-4a2c-abb1-9bdf10d2873e
Autor:
Arnaud Zaldumbide, Hailiang Mei, Bart O. Roep, Rob C. Hoeben, Francoise Carlotti, Bobby Koeleman, Leen M. ‘t Hart, Amadeo Munoz-Garcia, Flip Mulder, Jasper Boom, Arno R. van der Slik, Roderick C. Slieker, Sofia Thomaidou
Type 1 diabetes is an autoimmune disease characterized by autoreactive T-cell mediated destruction of the insulin-producing pancreatic beta-cells. Increasing evidence suggest that the beta-cells themselves contribute to their own destruction by gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14505a9c9c16ae166c3b8b04a0a2160e
https://doi.org/10.2337/figshare.14771181.v1
https://doi.org/10.2337/figshare.14771181.v1
Publikováno v:
Nature Reviews Endocrinology. NATURE RESEARCH
Nature Reviews Endocrinology
Nature Reviews. Endocrinology
Nature Reviews Endocrinology
Nature Reviews. Endocrinology
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that autoreactive T cells mistakenly destroy healthy (‘innocent’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1a3b008a69ae8f1765317cde42978c
https://hdl.handle.net/1887/3182660
https://hdl.handle.net/1887/3182660
Autor:
Sofia Thomaidou
Publikováno v:
EDULEARN Proceedings.
Publikováno v:
Diabetes, Obesity and Metabolism
Diabetes, Obesity and Metabolism, 20, 88-94
Diabetes, Obesity & Metabolism
Diabetes, Obesity and Metabolism, 20, 88-94
Diabetes, Obesity & Metabolism
β‐cell destruction in type 1 diabetes (T1D) results from the effect of inflammation and autoimmunity. In response to inflammatory signals, islet cells engage adaptive mechanisms to restore and maintain cellular homeostasis. Among these mechanisms,