Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells

Autor: Vaishnavi Venugopalan, Roberta E. Burden, Ekkehard Weber, Klaudia Brix, Zeynep Hein, Sebastian Springer, Dagmar Führer, Alexandra M. Pinzaru, Alaa Al-Hashimi, Christopher J. Scott, Sofia Tedelind, Naphannop Sereesongsaeng

Publikováno v: Al-Hashimi, A, Venugopalan, V, Sereesongsaeng, N, Tedelind, S, Pinzaru, A M, Hein, Z, Springer, S, Weber, E, Führer, D, Scott, C J, Burden, R E & Brix, K 2020, ' Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells ', Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1867, no. 12, 118846 . https://doi.org/10.1016/j.bbamcr.2020.118846

Altered expression and/or localization of cysteine cathepsins is believed to involve in thyroid diseases including cancer. Here, we examined the localization of cathepsins B and V in human thyroid tissue sections of different pathological conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eaa04364a841197516ab68e672b361
https://pure.qub.ac.uk/en/publications/3b2bc61c-db81-4ad1-9ad0-05a49eae32e2

Down-regulation of the Sodium/Iodide Symporter Explains 131I-Induced Thyroid Stunning

Autor: Sofia Tedelind, Mikael Nilsson, Madeleine M. Nordén, Eva Forssell-Aronsson, Fredrik Larsson, Charlotta Lundh, Therese Carlsson

Publikováno v: Cancer Research. 67:7512-7517

131I radiation therapy of differentiated thyroid cancer may be compromised by thyroid stunning (i.e., a paradoxical inhibition of radioiodine uptake caused by radiation from a pretherapeutic diagnostic examination). The stunning mechanism is yet unch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079b062833cc2565b1ed44538254d1eb
https://doi.org/10.1158/0008-5472.can-07-0823

Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues

Autor: Maria, Arampatzidou, Maren, Rehders, Stephanie, Dauth, Denise M T, Yu, Sofia, Tedelind, Klaudia, Brix

Publikováno v: Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia. 116(1)

The human genome encodes some hundreds of proteases. Many of these are well studied and understood with respect to their biochemistry, molecular mechanisms of proteolytic cleavage, expression patterns, molecular structure, substrate preferences and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69d2907390533dca6dc1328516fa216c
https://pubmed.ncbi.nlm.nih.gov/21898969

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

Autor: Klaudia Brix, Ruth Hunegnaw, Kseniia Poliakova, Amanda Valeta, Matthew Bogyo, Nataša Kopitar-Jerala, Boris Turk, Sofia Tedelind, Nils-Erik Heldin, Ekkehard Weber, Eyoel Lemma Yemanaberhan, Junichi Kurebayashi

Publikováno v: Tedelind, Sofia; Poliakova, Kseniia; Valeta, Amanda; Hunegnaw, Ruth; Yemanaberhan, Eyoel Lemma; Heldin, Nils-Erik; Kurebayashi, Junichi; Weber, Ekkehard; Kopitar-Jerala, Nata?a; Turk, Boris; Bogyo, Matthew; Brix, Klaudia (2010). Nuclear cysteine cathepsin variants in thyroid carcinoma cells. Biological chemistry, 391(8), pp. 923-35. Berlin: De Gruyter 10.1515/BC.2010.109

The cysteine peptidase cathepsin B is important in thyroid physiology by being involved in thyroid prohormone processing initiated in the follicular lumen and completed in endo-lysosomal compartments. However, cathepsin B has also been localized to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db20769c787cbb9bcfb1ac1c5425b09

Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease

Autor: Alexander Vidal, Fredrik Westberg, Sofia Tedelind, Martin Kjerrulf

Publikováno v: World Journal of Gastroenterology. 13:2826

AIM: To compare the anti-inflammatory properties of butyrate with two other SCFAs, namely acetate and propionate, which have less well-documented effects on inflammation. METHODS: The effect of SCFAs on cytokine release from human neutrophils was stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a50ad7819ee088c0aa5eb12f211a64a
https://doi.org/10.3748/wjg.v13.i20.2826