Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sofia Stinchi"'
Autor:
Floriane Lignet, Christina Esdar, Gina Walter-Bausch, Manja Friese-Hamim, Sofia Stinchi, Elise Drouin, Samer El Bawab, Andreas D. Becker, Claude Gimmi, Michael P. Sanderson, Felix Rohdich
Publikováno v:
The Journal of pharmacology and experimental therapeutics.
M3258 is an orally bioavailable, potent, selective, reversible inhibitor of the large multifunctional peptidase 7 (LMP7, β5i, PSMB8) proteolytic subunit of the immunoproteasome; a component of the cellular protein degradation machinery, highly expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0b32417eb18d77d30e0666a98cc907
https://pubmed.ncbi.nlm.nih.gov/36273822
https://pubmed.ncbi.nlm.nih.gov/36273822
Autor:
Kristina H. Holmberg, Mauro D'Antonio, Sofia Stinchi, Vittorio D'Urso, Yann Hyvert, Fernando Dangond, Jérôme Wojcik, Mark S. Freedman, Markus Fluck
Publikováno v:
Journal of Neuroimmunology. 360:577715
This post-hoc analysis evaluated candidate biomarkers of long-term efficacy of subcutaneous interferon beta-1a (sc IFN β-1a) in REFLEX/REFLEXION studies of clinically isolated syndrome. Samples from 507 REFLEX and 287 REFLEXION study participants we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d4746f5183c99232fbe059fddf7451
https://doi.org/10.1016/j.jneuroim.2021.577715
https://doi.org/10.1016/j.jneuroim.2021.577715
Autor:
Samer El Bawab, Frank Jährling, Sofia Stinchi, Florian Lignet, Willem Sloot, Felix Rohdich, Samantha Goodstal, Manja Friese-Hamim, Elise Drouin, Phlipp Haselmayer, Andreas Becker, Claude Gimmi, Christina Esdar, Anja Victor, Michael Sanderson, Gina Walter
Publikováno v:
Blood. 134:5582-5582
M3258 is an orally bioavailable, potent, selective, reversible inhibitor of the large multifunctional peptidase 7 (LMP7, β5i, PSMB8) proteolytic subunit of the immunoproteasome; a crucial component of the cellular protein degradation machinery, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80541ab22e5d2908d4d90ee0244b769e
https://doi.org/10.1182/blood-2019-126972
https://doi.org/10.1182/blood-2019-126972
Publikováno v:
Applied Microbiology and Biotechnology. 87:1633-1638
Nonomuraea strain ATCC 39727 produces the glycopeptide A40926, used for manufacturing dalbavancin, currently in advanced clinical trials. From the gene cluster involved in A40926 biosynthesis, a strain deleted in dbv23 was constructed. This mutant ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a27c9e963ebcaa98fd5cdc302274e4
https://doi.org/10.1007/s00253-010-2579-2
https://doi.org/10.1007/s00253-010-2579-2
Autor:
Marina Feroggio, Ameriga Lazzarini, Margherita Sosio, Sofia Stinchi, Lucia Carrano, Stefano Donadio, Armando Grigoletto
Publikováno v:
FEMS Microbiology Letters. 256:229-235
The actinomycete Nonomuraea sp. ATCC39727 produces the glycopeptide A40926. In the corresponding dbv cluster, ORF28 encodes a putative hydroxylase. A gene replacement mutant of ORF28 in Nonomuraea produces a small amount of an A40926-related metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4241d559062fbec9e6cb4cff59b40fd
https://doi.org/10.1111/j.1574-6968.2006.00120.x
https://doi.org/10.1111/j.1574-6968.2006.00120.x
Publikováno v:
Frontiers in Drug Design & Discovery. 1:3-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3e08b066751a229e11b9fa3d9e272a
https://doi.org/10.2174/1574088054583336
https://doi.org/10.2174/1574088054583336
Publikováno v:
Chemistry & Biology. 10(6):541-549
The glycopeptide A40926 is the precursor of dalbavancin, a second-generation glycopeptide currently under clinical development. The dbv gene cluster, devoted to A40926 biosynthesis, was isolated and characterized from the actinomycete Nonomuraea spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b38682c356ebe0f0ccf7b35a8c72be
Publikováno v:
Mammalian Genome. 11:436-439
Sulphamidase is an exoglycosidase involved in the degradation of heparan sulfate. Lack of sulphamidase activity leads to the lysosomal storage disorder Mucopolysaccharidosis type IIIA (Sanfilippo type A OMIM No. 252900). At present there are no natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726e471895cb404fdb21b717649cb955
https://doi.org/10.1007/s003350010083
https://doi.org/10.1007/s003350010083
Publikováno v:
Bioscience Reports. 19:157-162
α-mannosidosis in the human is an autosomal recessive lysosomal storage disease caused by a deficiency of lysosomal α-D-mannosidasea actvity. Lysosomal α-D-mannosidase is involved in the catabolism of N-linked glycoproteins through the sequential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b290949e85af147732dfcdc9143f7b13
https://doi.org/10.1023/a:1020217501465
https://doi.org/10.1023/a:1020217501465
Autor:
Egidia Costanzi, Sofia Stinchi, A. Orlacchio, A.R. Menghini, Antonio Orlacchio, J. L. Stirling, Tommaso Beccari
Publikováno v:
Mammalian Genome. 9:869-873
Mouse lysosomal alpha-d-mannosidase (EC 3.2.1.24) is an enzyme involved in the catabolism of N-linked glycoproteins. The gene is differentially expressed in mouse tissues, and the highest level of mRNA is found in the epididymis. The expression of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9e74f035e897d472d142d94af67f3b
https://doi.org/10.1007/s003359900885
https://doi.org/10.1007/s003359900885