Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Sofia S. Villar"'
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background The NOTACS trial will assess the efficacy, safety and cost-effectiveness of high-flow nasal therapy (HFNT) compared to standard oxygen therapy (SOT) on the outcomes of patients after cardiac surgery. Methods/design NOTACS is an ad
Externí odkaz:
https://doaj.org/article/ce6242ad83904f789b8b3d975d1614c5
Autor:
Thomas Burnett, Pavel Mozgunov, Philip Pallmann, Sofia S. Villar, Graham M. Wheeler, Thomas Jaki
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical, and efficient. These benefits are achieved while preserving the integrity and validity of the
Externí odkaz:
https://doaj.org/article/8db6bf99c1ed44a8bf747c4fe969db47
Autor:
Mia S. Tackney, Amber Steele, Joseph Newman, Marie-Christine Fritzsche, Federica Lucivero, Zarnie Khadjesari, Jennifer Lynch, Rosemary A. Abbott, Vicki S. Barber, James R. Carpenter, Bethan Copsey, Elin H. Davies, William G. Dixon, Lisa Fox, Javier González, Jessica Griffiths, Chloe H. L. Hinchliffe, Magdalena A. Kolanko, Dylan McGagh, Aryelly Rodriguez, George Roussos, Karen B. E. So, Louise Stanton, Mark Toshner, Frances Varian, Paula R. Williamson, Belay B. Yimer, Sofía S. Villar
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Digital technologies, such as wearable devices and smartphone applications (apps), can enable the decentralisation of clinical trials by measuring endpoints in people’s chosen locations rather than in traditional clinical settin
Externí odkaz:
https://doaj.org/article/cf6a5310e55e4b4fa7371bfea9434463
Publikováno v:
Resuscitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc71ffb3f57bcc422f6bc62f405bab
Autor:
Jonathan H. Mackay, Mathew V. Patteril, David J. Morrice, Sofia S. Villar, Jonathan W Brand, James Clayton, Yi-Da Chiu, Yajing Zhu
Publikováno v:
Resuscitation
Aims International early warning scores (EWS) including the additive National Early Warning Score (NEWS) and logistic EWS currently utilise physiological snapshots to predict clinical deterioration. We hypothesised that a dynamic score including vita
Autor:
Jules Hernández-Sánchez, David G. Kiely, J. Simon R. Gibbs, Joanna Pepke-Zaba, Christopher J. Rhodes, Brian Y.H. Lam, Luke Howard, Richard C. Trembath, Tae-Hwi Schwantes-An, Mark Toshner, John G Coghlan, Paul A. Corris, Amit Arora, Katie A. Lutz, Emily Knightbridge, Colin Church, Stefan Gräf, James Liley, Ken Batai, Marc Humbert, Ankit A. Desai, Louise Harlow, S. John Wort, Sean Gaine, Martin R. Wilkins, William C. Nichols, Rowena Jones, Sofia S Villar Moreschi, Jason H. Karnes, Rick A. Kittles, Lars Harbaum, Dee Gor, Florent Soubrier, Nicholas W. Morrell, Jay Suntharalingam, Michael W. Pauciulo
Publikováno v:
2022, ' Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension ', The European respiratory journal, vol. 59, no. 3, 2002463 . https://doi.org/10.1183/13993003.02463-2020
BackgroundInflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension (PAH). Compelling preclinical data supports the therapeutic blockade of interleukin-6 (IL-6) signalling.MethodsWe conducted a phase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669f2f7075fc94c5d8cdd8d56ad4951
https://kclpure.kcl.ac.uk/ws/files/170413390/Mendelian_randomisation_and_experimental_TOSHNER_Published_online_10_Mar_22_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/170413390/Mendelian_randomisation_and_experimental_TOSHNER_Published_online_10_Mar_22_GOLD_VoR_CC_BY_.pdf
Funder: NIHR Maudsley Biomedical Research Centre; funder-id: http://dx.doi.org/10.13039/100019418
When comparing the performance of multi-armed bandit algorithms, the potential impact of missing data is often overlooked. In practice, it also aff
When comparing the performance of multi-armed bandit algorithms, the potential impact of missing data is often overlooked. In practice, it also aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597c21d1ac0aabe0d6cdf022b0eeb0b1
https://www.repository.cam.ac.uk/handle/1810/342144
https://www.repository.cam.ac.uk/handle/1810/342144
Akademický článek
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Autor:
Jo-anne Fowles, Ian Scott, Alain Vuylsteke, Yi-Da Chiu, Julian Barker, Sofia S. Villar, Nicola Symes, Alex Warren, Luigi Camporota, Chris Harvey, Stephane Ledot
Publikováno v:
British Journal of Anaesthesia. 125:259-266
Background Extracorporeal membrane oxygenation (ECMO) is increasingly used to support adults with severe respiratory failure refractory to conventional measures. In 2011, NHS England commissioned a national service to provide ECMO to adults with refr
Autor:
Choo Ng, Karen Sheares, Luke S. Howard, Yi-Da Chiu, Dolores Taboada, Stephen J. Wort, Paul A. Corris, David G. Kiely, Martin Johnson, Alessandro Ruggiero, Joanna Pepke-Zaba, Katherine Bunclark, Sofia S. Villar, David P. Jenkins, Nicholas Screaton, Mark Toshner, Gerry Coghlan, John Cannon, Steven Tsui, Michael Newnham
Publikováno v:
Journal of Thrombosis and Haemostasis. 18:114-122
BACKGROUND Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of acute pulmonary emboli necessitating lifelong anticoagulation. Despite this, few data exist on the safety and efficacy of vitamin K antagonists (VKAs) in