Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A

Autor: Miquéias Lopes-Pacheco, Mafalda Bacalhau, Sofia S. Ramalho, Iris A. L. Silva, Filipa C. Ferreira, Graeme W. Carlile, David Y. Thomas, Carlos M. Farinha, John W. Hanrahan, Margarida D. Amaral

Publikováno v: Cells, Vol 11, Iss 1, p 136 (2022)

Although some therapeutic progress has been achieved in developing small molecules that correct F508del-CFTR defects, the mechanism of action (MoA) of these compounds remain poorly elucidated. Here, we investigated the effects and MoA of MCG1516A, a

Externí odkaz: https://doaj.org/article/8d80653a02ca4e2484d251cc2ae88f3a

Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction

Autor: Sónia Zacarias, Marta S. P. Batista, Sofia S. Ramalho, Bruno L. Victor, Carlos M. Farinha

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3211

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Currently, more than 2100 variants have been identified in the gene, with a large number being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4184fc6da8a94d33d8c3031c49981
https://doi.org/10.3390/ijms24043211

P-stalk ribosomes act as master regulators of cytokine-mediated processes.

Autor: Dopler A; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Alkan F; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Malka Y; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., van der Kammen R; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Hoefakker K; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Taranto D; Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Kocabay N; Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Mimpen I; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Ramirez C; Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Malzer E; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands., Isaeva OI; Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Kerkhoff M; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Gangaev A; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Silva J; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Ramalho S; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands., Hoekman L; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Altelaar M; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Beijersbergen R; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands., Akkari L; Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Yewdell JW; Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kvistborg P; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Faller WJ; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: w.faller@nki.nl.

Publikováno v: Cell [Cell] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.

Identifying ribosome heterogeneity using ribosome profiling.

Autor: Alkan F; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Wilkins OG; The Francis Crick Institute, London, UK.; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Hernández-Pérez S; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Ramalho S; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Silva J; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Ule J; The Francis Crick Institute, London, UK.; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; UK Dementia Research Institute Centre, King's College London, London, UK., Faller WJ; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Sep 09; Vol. 50 (16), pp. e95.

Exploring Correlates of Loss of Control Eating in a Nonclinical Sample.

Autor: Conceição EM; Psychotherapy and Psychopathology Research Unit - Psychology Research Centre, School of Psychology, University of Minho, Braga, Portugal., Moreira CS; Department of Mathematics and Center of Mathematics (FCUP-CMUP), University of Porto, Porto, Portugal., de Lourdes M; Psychotherapy and Psychopathology Research Unit - Psychology Research Centre, School of Psychology, University of Minho, Braga, Portugal., Ramalho S; Psychotherapy and Psychopathology Research Unit - Psychology Research Centre, School of Psychology, University of Minho, Braga, Portugal., Vaz AR; Psychotherapy and Psychopathology Research Unit - Psychology Research Centre, School of Psychology, University of Minho, Braga, Portugal.

Publikováno v: Frontiers in psychology [Front Psychol] 2022 Feb 11; Vol. 12, pp. 787558. Date of Electronic Publication: 2022 Feb 11 (Print Publication: 2021).