Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Sofia Ranta‐Aho"'
1
Akademický článek
Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage
Autor: Maija Toppila, Sofia Ranta-aho, Kai Kaarniranta, Maria Hytti, Anu Kauppinen
Publikováno v: Cells, Vol 13, Iss 17, p 1433 (2024)
Mitochondrial malfunction, excessive production of reactive oxygen species (ROS), deficient autophagy/mitophagy, and chronic inflammation are hallmarks of age-related macular degeneration (AMD). Metformin has been shown to activate mitophagy, allevia
Externí odkaz: https://doaj.org/article/acf3aaabe01447d4a84e333ff27fc783
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2
Akademický článek
The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
Autor: Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Publikováno v: Antioxidants, Vol 12, Iss 6, p 1279 (2023)
Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the r
Externí odkaz: https://doaj.org/article/ce97ecadff18401b970df3e6df209c3e
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3
Akademický článek
Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
Autor: Niina Bhattarai, Niina Piippo, Sofia Ranta-aho, Yashavanthi Mysore, Kai Kaarniranta, Anu Kauppinen
Publikováno v: Antioxidants, Vol 10, Iss 1, p 67 (2021)
Age-related macular degeneration (AMD) is an eye disease in which retinal pigment epithelium (RPE) cells play a crucial role in maintaining retinal homeostasis and photoreceptors’ functionality. During disease progression, there is increased inflam
Externí odkaz: https://doaj.org/article/cbc8eee749bb40c09325e97c98cec582
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4
The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
Autor: Kauppinen, Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu
Publikováno v: Antioxidants; Volume 12; Issue 6; Pages: 1279
Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::69a464878c2738691b5aec096ec8e725
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6
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Autor: Sofia Ranta-aho, Niina Piippo, Eveliina Korhonen, Kai Kaarniranta, Maria Hytti, Anu Kauppinen
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4875, p 4875 (2021)
Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation leading to the maturation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eeb55fb5c0e60dea5fc38b4cfcd4eb8a
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