Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sofia K. Gruvberger-Saal"'
Autor:
Malin Dahlgren, Barbara Lettiero, Hina Dalal, Kira Mårtensson, Alexander Gaber, Björn Nodin, Sofia K. Gruvberger-Saal, Lao H. Saal, Jillian Howlin
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-9 (2023)
Abstract Objective To investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role in mediating estrogen-dependant transcription. The study is a continuation of earlier work
Externí odkaz:
https://doaj.org/article/c9c6f678180546e18206439af403ab2a
Autor:
Hina Dalal, Malin Dahlgren, Sergii Gladchuk, Christian Brueffer, Sofia K. Gruvberger-Saal, Lao H. Saal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors and is the key biomarker to direct endocrine therapies. On the other hand, much less is known about estr
Externí odkaz:
https://doaj.org/article/d4846f6f066d4b8e98d670e12b1413cf
Autor:
Tina Catela Ivkovic, Helena Cornella, Gjendine Voss, Anson Ku, Margareta Persson, Robert Rigo, Sofia K. Gruvberger-Saal, Lao H. Saal, Yvonne Ceder
Publikováno v:
Cancers, Vol 15, Iss 15, p 3892 (2023)
Distant metastasis is the major cause of cancer-related deaths in men with prostate cancer (PCa). An in vivo functional screen was used to identify microRNAs (miRNAs) regulating metastatic dissemination of PCa cells. PC3 cells transduced with pooled
Externí odkaz:
https://doaj.org/article/7683128c60e740699e2303d31a0e7d37
Autor:
Mårten Fernö, Åke Borg, Jorma Isola, Per Malmström, Carsten Peterson, Patrik Edén, Cecilia Hegardt, Mervi Laakso, Lao H. Saal, Pär-Ola Bendahl, Sofia K. Gruvberger-Saal
Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERα)–positive breast carcinoma but are not indicated for persons with ERα-negative cancer. The factors responsible for response to tamoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da10c0df3e0eaa0907b1583792ff058
https://doi.org/10.1158/1078-0432.c.6518757.v1
https://doi.org/10.1158/1078-0432.c.6518757.v1
Autor:
Paul S. Meltzer, Carsten Peterson, Mårten Fernö, Åke Borg, Gunilla Chebil, Bo Baldetorp, Markus Ringnér, Patrik Edén, Sofia K. Gruvberger-Saal
The prognostic and treatment-predictive markers currently in use for breast cancer are commonly based on the protein levels of individual genes (e.g., steroid receptors) or aspects of the tumor phenotype, such as histological grade and percentage of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371b1ab64ae431bb681b0e5f7b8347a3
https://doi.org/10.1158/1535-7163.c.6532193
https://doi.org/10.1158/1535-7163.c.6532193
Autor:
Paul S. Meltzer, Carsten Peterson, Mårten Fernö, Åke Borg, Gunilla Chebil, Bo Baldetorp, Markus Ringnér, Patrik Edén, Sofia K. Gruvberger-Saal
Analysis + 1 Figure and 3 Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474079d6fcf3002d1f736cb77afeded8
https://doi.org/10.1158/1535-7163.22486022
https://doi.org/10.1158/1535-7163.22486022
Autor:
Mårten Fernö, Åke Borg, Jorma Isola, Per Malmström, Carsten Peterson, Patrik Edén, Cecilia Hegardt, Mervi Laakso, Lao H. Saal, Pär-Ola Bendahl, Sofia K. Gruvberger-Saal
Supplementary Materials and Methods, along with Supplementary Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011ae9bf6254e59d7711cccdfa686434
https://doi.org/10.1158/1078-0432.22441866.v1
https://doi.org/10.1158/1078-0432.22441866.v1
Autor:
Ramon Parsons, Hanina Hibshoosh, Vundavalli V.V.S. Murty, Jean J. Zhao, Gordon B. Mills, Alex Toker, Mary Beth Terry, Jorma Isola, Carlos Cordon-Cardo, Jennifer S. Yu, Tulio Matos, Albert Rojtman, Lorenzo Memeo, Xiaomei Wang, Mervi Laakso, Sofia K. Gruvberger-Saal, Jennifer S. Ferris, Da-In Kim, Y. Rebecca Chin, Yuli Xie, Bhaskar Dutta, Subhadra Nandula, Jiaping Wu, Christina R. Barkley, Benjamin D. Hopkins, Susan Koujak, Lao H. Saal, Tao Su, Matthew Maurer
Supplementary Information, Methods, Table 1, Figures 1-7 from 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25abfdbbb75ffe70019e086b41b57e62
https://doi.org/10.1158/0008-5472.22379426.v1
https://doi.org/10.1158/0008-5472.22379426.v1
Autor:
Ramon Parsons, Hanina Hibshoosh, Vundavalli V.V.S. Murty, Jean J. Zhao, Gordon B. Mills, Alex Toker, Mary Beth Terry, Jorma Isola, Carlos Cordon-Cardo, Jennifer S. Yu, Tulio Matos, Albert Rojtman, Lorenzo Memeo, Xiaomei Wang, Mervi Laakso, Sofia K. Gruvberger-Saal, Jennifer S. Ferris, Da-In Kim, Y. Rebecca Chin, Yuli Xie, Bhaskar Dutta, Subhadra Nandula, Jiaping Wu, Christina R. Barkley, Benjamin D. Hopkins, Susan Koujak, Lao H. Saal, Tao Su, Matthew Maurer
Lesions of ERBB2, PTEN, and PIK3CA activate the phosphatidylinositol 3-kinase (PI3K) pathway during cancer development by increasing levels of phosphatidylinositol-3,4,5-triphosphate (PIP3). 3-Phosphoinositide-dependent kinase 1 (PDK1) is the first n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8ae99672f79cca8bc9ea987720b521
https://doi.org/10.1158/0008-5472.c.6499247.v1
https://doi.org/10.1158/0008-5472.c.6499247.v1
Autor:
Malin Dahlgren, Barbara Lettiero, Hina Dalal, Kira Mårtensson, Alexander Gaber, Björn Nodin, Sofia K. Gruvberger-Saal, Lao H. Saal, Jillian Howlin
OBJECTIVE: We present our observations of CITED1 as a potential biomarker of anti-endocrine treatment response and recurrence in breast cancer and suggest that this is dependent on its role in mediating a specific ERα transcriptional response. The s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b68fe371f298cf63be7f8d9bf76bdf
https://doi.org/10.21203/rs.3.rs-2304366/v1
https://doi.org/10.21203/rs.3.rs-2304366/v1