Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Autor: Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolis

Externí odkaz: https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34

Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation

Autor: Janina Wittig, Maria-Kyriaki Drekolia, Anastasia Kyselova, Fredy Delgado Lagos, Magdalena L. Bochenek, Jiong Hu, Katrin Schäfer, Ingrid Fleming, Sofia-Iris Bibli

Publikováno v: Redox Biology, Vol 62, Iss , Pp 102694- (2023)

Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TF

Externí odkaz: https://doaj.org/article/c64a64aa8ebc45a1b6f1d0275628ebc7

The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

Autor: Frederike Boos, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Rüdiger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller, Ralf P. Brandes, Matthias S. Leisegang

Publikováno v: Basic Research in Cardiology, 118(1):5. Springer
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag

Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebbb1adb912075138984c27d421e77e
https://doi.org/10.1007/s00395-023-00978-3

A selective and sensitive method for quantification of endogenous polysulfide production in biological samples

Autor: Sofia-Iris Bibli, Bert Luck, Sven Zukunft, Janina Wittig, Wei Chen, Ming Xian, Andreas Papapetropoulos, Jiong Hu, Ingrid Fleming

Publikováno v: Redox Biology, Vol 18, Iss , Pp 295-304 (2018)

Hydrogen sulfide (H2S) is a gasotransmitter that regulates cellular homeostasis and impacts on multiple physiological and pathophysiological processes. However, it exerts many of its biological actions indirectly via the formation of H2S-derived sulf

Externí odkaz: https://doaj.org/article/ee3ee0d9c77446299f73470a60091a07

A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

Autor: Jiong Hu, Matthias S. Leisegang, Mario Looso, Gabrijela Dumbovic, Janina Wittig, Maria-Kyriaki Drekolia, Stefan Guenther, David John, Mauro Siragusa, Sven Zukunft, James Oo, Ilka Wittig, Susanne Hille, Andreas Weigert, Stefan Knapp, Ralf P. Brandes, Oliver J. Müller, Andreas Papapetropoulos, Fragiska Sigala, Gergana Dobreva, Ingrid Fleming, Sofia-Iris Bibli

AimsAdvanced age is unequivocally linked to the development of cardiovascular disease, however, the mechanisms leading to loss of endothelial cell regenerative capacity during aging remain poorly understood. Here we aimed to investigate novel mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9095d4723b704050d57a3f771ff2e151
https://doi.org/10.1101/2022.09.05.506654