Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sofia I. Porter"'
Autor:
Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.
Externí odkaz:
https://doaj.org/article/52e96531818443018246302cc0d348bc
Autor:
Hongming Ma, Wei Qian, Monika Bambouskova, Patrick L. Collins, Sofia I. Porter, Andrea K. Byrum, Rong Zhang, Maxim Artyomov, Eugene M. Oltz, Nima Mosammaparast, Jonathan J. Miner, Michael S. Diamond
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated da
Externí odkaz:
https://doaj.org/article/0f2c9b9750b24e7f848a405e26004f91
Autor:
Konstantin Zaitsev, Roman Chernyatchik, Patrick L. Collins, Sviatoslav Sidorov, Mykyta Artomov, Juhi Bagaitkar, Mark J. Daly, Ekaterina Loginicheva, Aleksei Dievskii, Amanda Swain, Eugene M. Oltz, Laura L. Arthur, Denis A. Mogilenko, Marko Jovanovic, Irina Shchukina, German Demidov, Oleg Shpynov, Christina Camell, Alexandra Panteleeva, Monika Bambouskova, Sheila A. Stewart, Maxim N. Artyomov, Sergey Dmitriev, Petr Tsurinov, Vishwa Deep Dixit, Sofia I. Porter, Erica Wolin, Evgeny Kurbatsky
Publikováno v:
Nature aging
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterat
Autor:
Craig H. Bassing, Patrick L. Collins, Ankita Saini, Katharina E. Hayer, Eugene M. Oltz, Jeffrey J. Bednarski, Caitlin E. Purman, Sofia I. Porter, Barry P. Sleckman, Vincent K. Nganga, Greer L. Gurewitz
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This histone modification spreads beyond the DSB into neighboring chromatin, generat
Autor:
Amanda Swain, Sheila A. Stewart, German Demidov, Marko Jovanovic, Alexandra Panteleeva, Konstantin Zaitsev, Vishwa Deep Dixit, Oleg Shpynov, Sofia I. Porter, Roman Chernyatchik, Aleksei Dievskii, Petr Tsurinov, Ekaterina Loginicheva, Denis A. Mogilenko, Juhi Bagaitkar, Monika Bambouskova, Irina Shchukina, Christina Camell, Maxim N. Artyomov, Sviatoslav Sidorov, Eugene M. Oltz, Erica Wolin, Laura L. Arthur, Evgeny Kurbatsky, Sergey Dmitriev, Mykyta Artomov, Mark J. Daly, Patrick L. Collins
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2ea2d7c8b548237e5d95ca4b1e7b01
https://doi.org/10.1101/2020.05.10.087023
https://doi.org/10.1101/2020.05.10.087023
Autor:
Caitlin E. Purman, Eugene M. Oltz, Patrick L. Collins, Harshath Gupta, Barry P. Sleckman, Sofia I. Porter, Ankita Saini
Publikováno v:
Mol Cell Biol
DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for e
Autor:
Michelle L. Robinette, Jennifer K. Bando, Patrick L. Collins, Thomas P. Burris, Ankita Saini, Laura A. Solt, Eugene M. Oltz, Marco Colonna, Cristiane Sécca, Qianli Wang, José Luís Fachi, Erik S. Musiek, Susan Gilfillan, Sofia I. Porter, Cyrielle Billon
Publikováno v:
Science Immunology. 4
Many gut functions are attuned to circadian rhythm. Intestinal group 3 innate lymphoid cells (ILC3s) include NKp46+ and NKp46- subsets, which are RORγt dependent and provide mucosal defense through secretion of interleukin-22 (IL-22) and IL-17. Beca
Autor:
Maxwell Hershey, Marco Colonna, Kenneth M. Murphy, Maxim N. Artyomov, Eugene Park, Sofia I. Porter, Konstantin Zaitsev, Michael D. Bern, Eugene M. Oltz, Wayne M. Yokoyama, Beatrice Plougastel-Douglas, Prabhakar S. Andhey, Swapneel J. Patel, L. David Sibley, Qiuling Wang, Patrick L. Collins
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, tumors may i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae894973b94aef846520f0551d2b7605
https://doi.org/10.1101/642017
https://doi.org/10.1101/642017
Autor:
Marina Cella, Henoch S. Hong, Patrick L. Collins, R. Paul Johnson, Greer L. Gurewitz, Sofia I. Porter, Shasha Li, Eugene M. Oltz, Marco Colonna
Publikováno v:
Cell. 176(1-2)
Summary Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets, which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their promise in adoptive cell therapies for cancer, a deeper und
Autor:
Eugene M. Oltz, Marina Cella, Sarah C. Pyfrom, Patrick L. Collins, Olivia I. Koues, Michelle L. Robinette, Sofia I. Porter, Jacqueline E. Payton, Marco Colonna
Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d16bf8950a04795c33378794a7dbe6
https://europepmc.org/articles/PMC4874868/
https://europepmc.org/articles/PMC4874868/