Výsledky vyhledávání - "Sofia Guerin Darvas"

Akademický článek

α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Autor: Kristian Leite, Pretty Garg, F. Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

α-synuclein (α-Syn) is intimately linked to synucleinopathies like Parkinson’s disease and dementia with Lewy bodies. However, the pathophysiological mechanisms that are triggered by this protein are still largely enigmatic. α-Syn overabundance

Externí odkaz: https://doaj.org/article/24dc0e7485754e85828935a5cb57124f

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Dementia with Lewy bodies—associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions

Autor: Sameehan Mahajani, Kristian Leite, Maryna Psol, Sebastian Kügler, Sofia Guerin Darvas, Mathias Bähr

Publikováno v: Human Molecular Genetics. 30:247-264

Beta (ß)-synuclein (ß-Syn) has long been considered to be an attenuator for the neuropathological effects caused by the Parkinson’s disease-related alpha (α)-synuclein (α-Syn) protein. However, recent studies demonstrated that overabundant ß-S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec882cc475adc84a598dfcd8c224206d
https://doi.org/10.1093/hmg/ddab036

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