Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sofia Ferreira Gonzalez"'
Autor:
Yunxi Gao, Victoria L. Gadd, Maria Heim, Rhiannon Grant, Thomas S. R. Bate, Hannah Esser, Sofia Ferreira Gonzalez, Tak Yung Man, Stuart J. Forbes, Anthony Callanan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Liver disease cases are rapidly expanding worldwide, and transplantation remains the only effective cure for end-stage disease. There is an increasing demand for developing potential drug treatments, and regenerative therapies using in-vitro
Externí odkaz:
https://doaj.org/article/296f78107bb74eb78576ef134603feee
Autor:
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552- (2021)
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In
Externí odkaz:
https://doaj.org/article/0fd0f2e5fb724e438758d7df1a29d1bc
Autor:
Sofia Ferreira-Gonzalez, Wei-Yu Lu, Alexander Raven, Benjamin Dwyer, Tak Yung Man, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Tim J. Kendall, Thomas G. Bird, Nuria Tarrats, Juan-Carlos Acosta, Luke Boulter, Stuart J. Forbes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dep
Externí odkaz:
https://doaj.org/article/fec37437098140028922b5a6d61c5040
Autor:
Sofia Ferreira-Gonzalez, Tak Yung Man, Hannah Esser, Rhona Aird, Alastair M. Kilpatrick, Daniel Rodrigo-Torres, Nicholas Younger, Lara Campana, Victoria L. Gadd, Benjamin Dwyer, Niya Aleksieva, Luke Boulter, Mark T. Macmillan, Yinmiao Wang, Katie J. Mylonas, David A. Ferenbach, Timothy J. Kendall, Wei-Yu Lu, Juan Carlos Acosta, Dominic Kurian, Stephen O’Neill, Gabriel C. Oniscu, Jesus M. Banales, Paul J. Krimpenfort, Stuart J. Forbes
Publikováno v:
Ferreira-Gonzalez, S, Man, T Y, Esser, H, Aird, R, Kilpatrick, A, Rodrigo Torres, D, Younger, N, Campana, L, Gadd, V, Dwyer, B, Aleksieva, N, Boulter, L, Macmillan, M, Wang, Y, Mylonas, K J, Ferenbach, D A, Kendall, T J, Lu, W-Y, Acosta, J C, Kurian, D, O'Neill, S, Oniscu, G, Banales, J M, Krimpenfort, P & Forbes, S J 2022, ' Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage ', Science Translational Medicine, vol. 14, no. 674, eabj4375 . https://doi.org/10.1126/scitranslmed.abj4375
Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue to occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d4735d36e8e39daf53ab681bc8df9
https://doi.org/10.1126/scitranslmed.abj4375
https://doi.org/10.1126/scitranslmed.abj4375
Autor:
Cornelius Engelmann, Abeba Habtesion, Mohsin Hassan, Annarein JC. Kerbert, Linda Hammerich, Simone Novelli, Marco Fidaleo, Alexandra Philips, Nathan Davies, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Thomas Berg, Fausto Andreola, Rajiv Jalan
Publikováno v:
Engelmann, C, Habtesion, A, Hassan, M, Kerbert, A JC, Hammerich, L, Novelli, S, Fidaleo, M, Philips, A, Davies, N, Ferreira-Gonzalez, S, Forbes, S J, Berg, T, Andreola, F & Jalan, R 2022, ' Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF ', Journal of Hepatology, vol. 77, no. 5, pp. 1325-1338 . https://doi.org/10.1016/j.jhep.2022.07.006
Journal Hepathology
Journal Hepathology
Background & Aims: Acute-on-chronic liver failure (ACLF) is characterised by high short-term mortality, systemic inflammation, and failure of hepatic regeneration. Its treatment is a major unmet medical need. This study was conducted to explore wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50997bbb1d2e7489e82625d1f4f96ff7
https://hdl.handle.net/20.500.11820/4c3ed0e6-23ac-4d92-9332-33beb91bd906
https://hdl.handle.net/20.500.11820/4c3ed0e6-23ac-4d92-9332-33beb91bd906
Autor:
Nathan Davies, Thomas Berg, Stuart J. Forbes, Annarein J. C. Kerbert, Cornelius Engelmann, A Habtesion, Simone Novelli, Fausto Andreola, Rajiv Jalan, Sofia Ferreira-Gonzalez
Publikováno v:
Posters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d9831f52cd8c648aa416937c76cfc50
https://doi.org/10.1136/gutjnl-2021-basl.101
https://doi.org/10.1136/gutjnl-2021-basl.101
Autor:
Himjyot Jaiswal, Philip J. Starkey Lewis, Carl S. Tucker, James W. Dear, Joanna Simpson, Jeremy Hughes, Oliver Flint, Sofia Ferreira-Gonzalez, Baltasar Lucendo-Villarin, Natalie Z.M. Homer, Esther Mellado-Gomez, Stuart J. Forbes, Enrique M. Toledo, Allan E. Karlsen, Nicola L. Beer, Jose Meseguer-Ripolles, David C. Hay, Yu Wang
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552-(2021)
iScience
Meseguer Ripolles, J, Lucendo Villarin, B, Tucker, C, Ferreira-Gonzalez, S, Homer, N Z M, Wang, Y, Starkey Lewis, P, Toledo Maldonado, E, Mellado-Gomez, E, Simpson, J, Flint, O, Jaiswal, H, Beer, N L, Karlsen, A E, Forbes, S J, Dear, J W, Hughes, J & Hay, D C 2021, ' Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure ', iScience . https://doi.org/10.1016/j.isci.2021.102552
iScience
Meseguer Ripolles, J, Lucendo Villarin, B, Tucker, C, Ferreira-Gonzalez, S, Homer, N Z M, Wang, Y, Starkey Lewis, P, Toledo Maldonado, E, Mellado-Gomez, E, Simpson, J, Flint, O, Jaiswal, H, Beer, N L, Karlsen, A E, Forbes, S J, Dear, J W, Hughes, J & Hay, D C 2021, ' Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure ', iScience . https://doi.org/10.1016/j.isci.2021.102552
Summary Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdff51b399cc36931be0cfae794edeb1
http://www.sciencedirect.com/science/article/pii/S2589004221005204
http://www.sciencedirect.com/science/article/pii/S2589004221005204
Autor:
Hannah Esser, Sofia Ferreira-Gonzalez, Tak Yung Man, Alastair Kilpatrick, Daniel Rodrigo Torres, Rhona E. Aird, Candice Ashmore-Harris, Kayleigh Thirlwell, Benjamin J. Dwyer, Gabriel Oniscu, Stefan Schneeberger, Luke Boulter, Stuart Forbes
Publikováno v:
Journal of Hepatology. 77:S85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1e5a48951fea8cde7863352fb24763
https://doi.org/10.1016/s0168-8278(22)00563-3
https://doi.org/10.1016/s0168-8278(22)00563-3
Autor:
Anette Melk, David P. Baird, Sarah A. Neely, Paul Krimpenfort, Sofia Ferreira-Gonzalez, Jeremy Hughes, Marie-Helena Docherty, Duncan Humphries, Roland Schmitt, Katie J. Mylonas, David A. Ferenbach, Eoin O'Sullivan, Stuart J. Forbes
Publikováno v:
Mylonas, K J, O'Sullivan, E, Humphries, D, Baird, D, Docherty, M-H, Neely, S, Krimpenfort, P, Melk, A, Schmitt, R, Ferreira-Gonzalez, S, Forbes, S J, Hughes, J & Ferenbach, D A 2021, ' Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair ', Science Translational Medicine . https://doi.org/10.1126/scitranslmed.abb0203
The ability of the kidney to regenerate successfully after injury is lost with advancing age, chronic kidney disease and after irradiation. The factors responsible for this reduced regenerative capacity remain incompletely understood, with increasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6807ac36b7eef2036175beb443aad0
https://www.pure.ed.ac.uk/ws/files/211798980/Full_manuscript_as_pdf.pdf
https://www.pure.ed.ac.uk/ws/files/211798980/Full_manuscript_as_pdf.pdf
Autor:
John M. Hallett, Sofia Ferreira-Gonzalez, Tak Yung Man, Alastair M. Kilpatrick, Hannah Esser, Kayleigh Thirlwell, Mark T. Macmillan, Daniel Rodrigo-Torres, Benjamin J. Dwyer, Victoria L. Gadd, Candice Ashmore-Harris, Wei-Yu Lu, John P. Thomson, Maurits A. Jansen, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Rhona E. Aird, Thomas S.R. Bate, Alasdair R. Fraser, John D.M. Campbell, Gabriel C. Oniscu, David C. Hay, Anthony Callanan, Stuart J. Forbes
Publikováno v:
Hallett, J, Ferreira-Gonzalez, S, Man, J, Kilpatrick, A, Esser, H, Thirwell, K, Macmillan, M, Rodrigo Torres, D, Dwyer, B, Gadd, V, Ashmore-Harris, C, Lu, W-Y, Thomson, J, Jansen, M, O'Duibhir, E, Starkey Lewis, P, Campana, L, Aird, R, Bate, T, Fraser, A R, Campbell, J D M, Oniscu, G C, Hay, D C, Callanan, A & Forbes, S J 2022, ' Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease ', Cell Stem Cell . https://doi.org/10.1016/j.stem.2022.02.006
Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required. We have therefore puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac8dd45230457bbbf0f9ff444a375c
https://pubmed.ncbi.nlm.nih.gov/35245462
https://pubmed.ncbi.nlm.nih.gov/35245462