Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sofia Annis"'
Autor:
Robert Logan, Zoe Fleischmann, Sofia Annis, Amy Wangsness Wehe, Jonathan L. Tilly, Dori C. Woods, Konstantin Khrapko
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Third-generation sequencing offers some advantages over next-generation sequencing predecessors, but with the caveat of harboring a much higher error rate. Clustering-related sequences is an essential task in modern biology. To ac
Externí odkaz:
https://doaj.org/article/30ff4bd2fcb74a6aafbb02ea207905cd
Autor:
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/f75ae1b920ed4388b4b98edd05c4de18
Autor:
Konstantin Popadin, Konstantin Gunbin, Leonid Peshkin, Sofia Annis, Zoe Fleischmann, Melissa Franco, Yevgenya Kraytsberg, Natalya Markuzon, Rebecca R. Ackermann, Konstantin Khrapko
Publikováno v:
Genes, Vol 13, Iss 5, p 810 (2022)
The hypothesis that the evolution of humans involves hybridization between diverged species has been actively debated in recent years. We present the following novel evidence in support of this hypothesis: the analysis of nuclear pseudogenes of mtDNA
Externí odkaz:
https://doaj.org/article/e9d165117605438aaac247b88c743cab
Autor:
Konstantin Gunbin, Leonid Peshkin, Konstantin Popadin, Sofia Annis, Rebecca R. Ackermann, Konstantin Khrapko
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 536-544 (2017)
The data and methods presented in this article are supplementing the research article ''Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis'', DOI: 10.1016/j.mito.2016.12.001 (Gunbin et
Externí odkaz:
https://doaj.org/article/c220cc40b37644789d17081b4c500900
Autor:
Thomas Bertero, Katherine A. Cottrill, Yu Lu, Christina M. Haeger, Paul Dieffenbach, Sofia Annis, Andrew Hale, Balkrishen Bhat, Vivek Kaimal, Ying-Yi Zhang, Brian B. Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, Sara O. Vargas, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Laura E. Fredenburgh, Stephen Y. Chan
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 1016-1032 (2015)
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular c
Externí odkaz:
https://doaj.org/article/f5da7c8f7754420ab4de6ee73b9f1bf3
Autor:
Zoë Fleischmann, Auden Cote-L’Heureux, Melissa Franco, Sergey Oreshkov, Sofia Annis, Mark Khrapko, Dylan Aidlen, Konstantin Popadin, Dori C. Woods, Jonathan L. Tilly, Konstantin Khrapko
The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c177685e6fd9f1df3ef5da36f93ea208
https://doi.org/10.1101/2022.12.12.520138
https://doi.org/10.1101/2022.12.12.520138
Autor:
Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin
Publikováno v:
Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779
The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779
https://doi.org/10.1093/nar/gkac779
Autor:
S. Orseshkov, Sofia Annis, Jonathan L. Tilly, Dori C. Woods, Melissa Franco, Konstantin Popadin, Zoe Fleischmann, Konstantin Khrapko
The resilience of the mitochondrial genome to a high mutational pressure depends, in part, on purifying selection against detrimental mutations in the germline. It is crucial to understand the mechanisms of this process. Recently, Floros et al. concl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb47b493d36c06be0e69a0983ac9ae9
https://doi.org/10.1101/2021.10.18.464832
https://doi.org/10.1101/2021.10.18.464832
Autor:
Robert Logan, Zoe Fleischmann, Sofia Annis, Amy Wehe, Jonathan L. Tilly, Dori C. Woods, Konstantin Khrapko
Background Third-generation sequencing offers some advantages over next-generation sequencing predecessors, but with the caveat of harboring a much higher error rate. Clustering-related sequences is an essential task in modern biology. To accurately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9d8e7a237cca89c05cde98ecb31475
https://doi.org/10.21203/rs.3.rs-982478/v1
https://doi.org/10.21203/rs.3.rs-982478/v1
Autor:
Robert Logan, Josefin Saürich, Sofia Annis, Zachary Mullin-Bernstein, Zoe Fleischmann, Konstantin Khrapko, Melissa Franco, Dori C. Woods, Jonathan L. Tilly
Publikováno v:
Aging (Albany NY)
Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequenc