miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling

Autor: Marcus J. Hines, Maryaline Coffre, Tenny Mudianto, Marisella Panduro, Eric J. Wigton, Cosmin Tegla, Victoria Osorio-Vasquez, Robin Kageyama, David Benhamou, Oriana Perez, Sofia Bajwa, Michael T. McManus, K. Mark Ansel, Doron Melamed, Sergei B. Koralov

Publikováno v: Cell Reports, Vol 33, Iss 9, Pp 108436- (2020)

Summary: The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and te

Externí odkaz: https://doaj.org/article/a347eca3ff184d66badee443d3b201b8

Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice

Autor: Jason Aligo, Bo Shopsin, Ashira Lubkin, Matthew D. Keller, Rita Chan, Anthony Simon Lynch, Victor J. Torres, Maryaline Coffre, Daniel Weinstock, Michael Sugiyama, Francis Alonzo rd, Sergei B. Koralov, Eric Chen, Sofia Bajwa, Ken Cadwell, Nikollaq Vozhilla, Johnny Su, G. Scott Worthen, Changsen Wang, Sang Yong Kim, Peter T. Buckley, Natasha M. Girgis, P'ng Loke, Warren L. Lee, Kamal M. Khanna, Patricia Martin, Marilyn T. Vasquez, Cynthia A. Loomis, Stephen T. Yeung, Aidan O’Malley, Tamara Reyes-Robles

Publikováno v: Cell Host & Microbe. 25:463-470.e9

Summary The pathogenesis of Staphylococcus aureus is thought to depend on the production of pore-forming leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin ED (LukED) and γ-Hemolysin AB (HlgAB), are necessary and suf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24125441d0686ec448dd520e79f84f46
https://doi.org/10.1016/j.chom.2019.01.015

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

Autor: Doron Melamed, Sofia Bajwa, Tirtha Chakraborty, Marcus J. Hines, Gregg J. Silverman, Robert Blelloch, Lili Blumenberg, Lelise Getu, Mark M.W. Chong, Dinis Pedro Calado, Jane A. Skok, Sergei B. Koralov, Valentina Snetkova, David Benhamou, Maryaline Coffre, Kari Jensen, Dan R. Littman, Klaus Rajewsky, David Rieß

Publikováno v: Coffre, M; Benhamou, D; Rieß, D; Blumenberg, L; Snetkova, V; Hines, MJ; et al.(2016). miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. Cell Reports, 17(9), 2271-2285. doi: 10.1016/j.celrep.2016.11.006. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/4ks9128q
Cell reports, vol 17, iss 9
Cell Reports

© 2016 The Author(s) B cell development is a tightly regulated process dependent on sequential rearrangements of immunoglobulin loci that encode the antigen receptor. To elucidate the role of microRNAs (miRNAs) in the orchestration of B cell develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1abbb201abbc9df76502cfc587f5df
http://www.escholarship.org/uc/item/4ks9128q

Novel insights into Th17 mediated airway inflammation (HYP7P.259)

Autor: Sergei Koralov, Laura Fogli, Melania Fanok, Joan Durbin, Ken Cadwell, Sofia Bajwa, Klaus Rajewsky, swati goel, Mark Sundrud, Leopoldo Segal

Publikováno v: The Journal of Immunology. 194:191.7-191.7

Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the pathogenesis of asthma. Yet the direct impact of IL-17 and IL-22 on the lung epithelium remains to be fully elucidated. We took advantage of conditional gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e29356a59814b45bd173e92c87dac8b
https://doi.org/10.4049/jimmunol.194.supp.191.7