Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sofi K. C. Elmroth"'
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 1, Pp m164-m165 (2008)
The dinuclear title compound, [FePtCl2(C17H14P)(C23H23NO3P)]·1.25CH2Cl2, has a slightly distorted cis-PtCl2P2 square-planar geometry around the Pt atom, and the ferrocenylphosphine ligands are staggered at an angle of 29.4 (2)° about Pt. In the cry
Externí odkaz:
https://doaj.org/article/445604c04ce648ddbe91c8e02469cc3e
Publikováno v:
Dalton Transactions. 44:12623-12632
Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous studies have shown that the reaction between small duplex RNAs (dsRNAs) and monoaquated cisplat
Autor:
Ana Rilak, Sofi K. C. Elmroth, Olivera R. Klisurić, Ioannis Bratsos, Živadin D. Bugarčić, Goran Davidovic, Milan M. Milutinović
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 46(7)
In this study, we investigated the ability of Ru(ii) polypyridyl complexes to act as DNA binders. The substitution reactions of three Ru(ii) chlorophenyl terpyridine complexes, i.e. [Ru(Cl-Ph-tpy)(en)Cl]Cl (1), [Ru(Cl-Ph-tpy)(dach)Cl]Cl (2) and [Ru(C
Publikováno v:
Zeitschrift für anorganische und allgemeine Chemie. 639:1655-1660
Thermodynamic parameters are presented here illustrating the effects caused by the two anticancer active metal complexes cisplatin and oxaliplatin after introduction into four closely related RNA and DNA duplexes. The duplexes used are blunt end, ful
Autor:
Jiri Gut, Frederik H. Kriel, Sofi K. C. Elmroth, Lara C. Spencer, Raymond Hewer, Judy Coates, Constance E.J. Van Rensburg, James Darkwa, Tina Persson, Philip J. Rosenthal, Haris Bjelosevic, Ilia A. Guzei, Margo Nell
Publikováno v:
Journal of Organometallic Chemistry. 720:52-59
The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geo
Autor:
Jovana Bogojeski, Živadin D. Bugarčić, Sofi K. C. Elmroth, Olivera R. Klisurić, Andreas Scheurer, Milan M. Milutinović
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 45(39)
A novel rhodium(III) complex [RhIII(H2LtBu)Cl3] (1) (H2LtBu = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine) containing a pincer type, tridentate nitrogen-donor chelate system was synthesized. Single crystal X-ray structure analysis revealed that 1 c
Publikováno v:
European Journal of Organic Chemistry. 2010:6161-6170
Modification and optimization of the anticancer drug cisplatin is of interest with respect to selective cell targeting and DNA binding efficiency. Attractive approaches contain both, modification of the platinum coordination sphere and design of hybr
Publikováno v:
Organicbiomolecular chemistry. 13(48)
Conjugation of metal complexes with peptide scaffolds possessing high DNA binding affinity has shown to modulate their biological activities and to enhance their interaction with DNA. In this work, a platinum complex/peptide chimera was synthesized b
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 11:974-990
The DNA interference pathways exhibited by cisplatin and related anticancer active metal complexes have been extensively studied. Much less is known to what extent RNA interaction pathways may operate in parallel, and perhaps contribute to both antin
Autor:
Sofi K. C. Elmroth, Haris Bjelosevic, Åse Sykfont Snygg, Christer Spegel, Lo Gorton, Tina Persson
Publikováno v:
Tetrahedron. 62:4519-4527
Among the metal-based anticancer drugs, cisplatin (cis-diaminedichloroplatinum(II)) is the most widely used species in therapy. Despite its clinical success, cisplatin still suffers in generating resistance, as well as being highly toxic due to poor