Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sofhia V Ramos"'
Autor:
Sofhia V Ramos, Meghan C Hughes, Luca J Delfinis, Catherine A Bellissimo, Christopher G R Perry
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0237138 (2020)
In Duchenne muscular dystrophy, a lack of dystrophin leads to extensive muscle weakness and atrophy that is linked to cellular metabolic dysfunction and oxidative stress. This dystrophinopathy results in a loss of tethering between microtubules and t
Externí odkaz:
https://doaj.org/article/785268f5094a415c8a3550bc0e4d5d0e
Autor:
Martina Rudnicki, Ghoncheh Abdifarkosh, Emmanuel Nwadozi, Sofhia V Ramos, Armin Makki, Diane M Sepa-Kishi, Rolando B Ceddia, Christopher GR Perry, Emilie Roudier, Tara L Haas
Publikováno v:
eLife, Vol 7 (2018)
Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined. Here, we demonstrate that induced endothelial-specific d
Externí odkaz:
https://doaj.org/article/9ddbde5c9f254a51ad37c21d8b322840
Autor:
Meghan C. Hughes, Sofhia V. Ramos, Aditya N. Brahmbhatt, Patrick C. Turnbull, Nazari N. Polidovitch, Madison C. Garibotti, Uwe Schlattner, Thomas J. Hawke, Jeremy A. Simpson, Peter H. Backx, Christopher GR. Perry
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103319- (2024)
Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such “creatine-dependent” phosphate shuttling is attenuated i
Externí odkaz:
https://doaj.org/article/a74cffb251704d729df4c25f1d7a8846
Autor:
Meghan C Hughes, Sofhia V Ramos, Patrick C Turnbull, Ali eNejatbakhsh, Brittany L Baechler, Houman eTahmasebi, Robert eLaham, Brendon J Gurd, Joe eQuadrilatero, Daniel A Kane, Christopher G.R. Perry
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent
Externí odkaz:
https://doaj.org/article/95fa9f502dcb4495b761528b16472e75
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120136 (2015)
The rate-limiting enzyme in lipolysis, adipose triglyceride lipase (ATGL), is activated by comparative gene identification-58 (CGI-58) and inhibited by the G(0)/G(1) switch gene-2 (G0S2) protein. It is speculated that inhibition of ATGL is through a
Externí odkaz:
https://doaj.org/article/ac75f96a4b194370922630813cef8d5b
Autor:
Theresa Mau, Li-Yung Lui, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Frederico G S Toledo, Adam J Santanasto, Eric G Shankland, David J Marcinek, Michael J Jurczak, Ian Sipula, Fiona M Bello, Kate A Duchowny, Anthony J A Molina, Lauren M Sparks, Bret H Goodpaster, Russell T Hepple, Stephen B Kritchevsky, Anne B Newman, Peggy M Cawthon, Steven R Cummings, Paul M Coen
Publikováno v:
The Journals of Gerontology: Series A.
BackgroundMitochondrial energetics are an important property of aging muscle, as generation of energy is pivotal to the execution of muscle contraction. However, its association with functional outcomes, including leg power and cardiorespiratory fitn
Autor:
SOFHIA V. RAMOS, GIOVANNA DISTEFANO, PEGGY CAWTHON, STEPHANIE M. MARSHALL, PHILIP KRAMER, ANTHONY MOLINA, MICHAEL J. JURCZAK, FREDERICO TOLEDO, BRET H. GOODPASTER, PAUL M. COEN
Publikováno v:
Diabetes. 71
Skeletal muscle mitochondrial capacity is reduced in both aging and diabetes. Whether diabetes further impairs mitochondrial capacity in older adults and how this relates to cardiorespiratory fitness (VO2peak) and glycemic control (HbA1c) remains unc
Autor:
Uwe Schlattner, Patrick C. Turnbull, Nazari Polidovitch, Peter H. Backx, Christopher G. R. Perry, Jason S. Huber, Jeremy A. Simpson, Meghan C. Hughes, Sofhia V. Ramos, Brittany A. Edgett
Publikováno v:
The Journal of Physiology
The Journal of Physiology, Wiley, 2019, ⟨10.1113/JP277306⟩
The Journal of Physiology, Wiley, 2019, ⟨10.1113/JP277306⟩
International audience; KEY POINTS:Ninety-eight per cent of patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy, with 40% developing heart failure. While increased propensity for mitochondrial induction of cell death has been obser
Autor:
Robert Laham, Sofhia V. Ramos, Christopher G. R. Perry, Cynthia M. F. Monaco, Meghan C. Hughes, Catherine A. Bellissimo, Thomas J. Hawke
Publikováno v:
Am J Physiol Endocrinol Metab
Sexual dimorphism in mitochondrial respiratory function has been reported in young women and men without diabetes, which may have important implications for exercise. The purpose of this study was to determine if sexual dimorphism exists in skeletal
Publikováno v:
American Journal of Physiology-Cell Physiology. 316:C449-C455
Microtubule-targeting chemotherapies are linked to impaired cellular metabolism, which may contribute to skeletal muscle dysfunction. However, the mechanisms by which metabolic homeostasis is perturbed remains unknown. Tubulin, the fundamental unit o