Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sofía Carbajosa"'
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/c96b11721b9b47a1ac2f8d97e71e0b1f
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://doaj.org/article/8d32f189375347eda9d14d8aef197263
Autor:
Maria Eugenia Sabatino, Andrés Castellaro, Ana C. Racca, Sofía Carbajosa González, Maria Florencia Pansa, Gastón Soria, Jose Luis Bocco
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its frequent genomic loss or do
Externí odkaz:
https://doaj.org/article/f88210b449a348e6978d7bb003bfd45e
Autor:
Sofía Carbajosa, Héctor O Rodríguez-Angulo, Susana Gea, Carlos Chillón-Marinas, Cristina Poveda, María C Maza, Diana Colombet, Manuel Fresno, Núria Gironès
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006179 (2018)
Chagas disease caused by Trypanosoma cruzi is a neglected disease that affects about 7 million people in Latin America, recently emerging on other continents due to migration. As infection in mice is characterized by depletion of plasma L-arginine, t
Externí odkaz:
https://doaj.org/article/c7e4c28ff2fb4117bab8fb2921e43430
Autor:
Núria Gironès, Sofía Carbajosa, Néstor A Guerrero, Cristina Poveda, Carlos Chillón-Marinas, Manuel Fresno
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3337 (2014)
Chagas disease is caused by Trypanosoma cruzi infection, being cardiomyopathy the more frequent manifestation. New chemotherapeutic drugs are needed but there are no good biomarkers for monitoring treatment efficacy. There is growing evidence linking
Externí odkaz:
https://doaj.org/article/c01a6981802342ae92ad8a615e786472
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65820 (2013)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects several million people in Latin America. Myocarditis, observed during both the acute and chronic phases of the disease, is characterized by an inflammatory mononuclear cell
Externí odkaz:
https://doaj.org/article/bc91455027184cd295d265e0434bab6c
Autor:
Sebastián Omar Siri, Julieta Martino, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife. 12
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e4416eea641ab4ae8542b969bfab9b
https://doi.org/10.7554/elife.80254
https://doi.org/10.7554/elife.80254
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Legends included in the figure file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a26ecc52181f0eb97f308f30e83b607
https://doi.org/10.1158/1078-0432.22472220.v1
https://doi.org/10.1158/1078-0432.22472220.v1
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Purpose:BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34135ca0a46fae703101f62ea39fe83c
https://doi.org/10.1158/1078-0432.c.6528156.v1
https://doi.org/10.1158/1078-0432.c.6528156.v1
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Full list of hits of the BRCA1-deficient population in the screening performed with the PKIS2 library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056d2d9059527e3232a57cd78b0f096
https://doi.org/10.1158/1078-0432.22472202
https://doi.org/10.1158/1078-0432.22472202