SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity

Autor: Sofía C. Khouili, Emma C.L. Cook, Elena Hernández-García, María Martínez-López, Ruth Conde-Garrosa, Salvador Iborra

Publikováno v: Cell Reports, Vol 33, Iss 9, Pp 108468- (2020)

Summary: Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentation in dendri

Externí odkaz: https://doaj.org/article/c59568341b2f4dc597b1bf14e68d210e

Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells

Autor: Michel Enamorado, Sofía C. Khouili, Salvador Iborra, David Sancho

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Tissue-resident memory CD8+ T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumo

Externí odkaz: https://doaj.org/article/9f1acf5cb4964f84ac35dd1114cf6bcb

Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3-dependent spread immunity against endogenous tumor antigens

Autor: David Sancho, Paula Jaime-Sánchez, Nacho Aguilo, Sofía C. Khouili, Julián Pardo, Iratxe Uranga-Murillo, Maykel Arias

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

6 Figures
[Background] Elimination of cancer cells by some stimuli like chemotherapy and radiotherapy activates anticancer immunity after the generation of damage‐associated molecular patterns, a process recently named immunogenic cell death (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d56308ffac1550ba0b50c0e0361a7a0
https://hdl.handle.net/20.500.12105/9629

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Autor: Joaquín Amores-Iniesta, Ignacio Melero, Stefanie K. Wculek, Ruth Conde-Garrosa, Sofía C. Khouili, David Sancho

Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer
Dadun. Depósito Académico Digital de la Universidad de Navarra
Consejo Superior de Investigaciones Científicas (CSIC)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)

BACKGROUND: The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdb0b79a5522edca1af326cd6f180f7
https://hdl.handle.net/20.500.12105/7504

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

Autor: Michel Enamorado, David Sancho, Francisco J. Cueto, María Martínez-López, Sofía C. Khouili, Ruth Conde-Garrosa, Salvador Iborra, Carlos del Fresno

Publikováno v: Immunity. 45:847-860

Despite the crucial role of tissue-resident memory T (Trm) cells in protective immunity, their priming remains poorly understood. Here, we have shown differential priming requirements for Trm versus circulating memory CD8+ T cells. In vaccinia cutane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c02c22a132a65668d9e9d7eae7aed036
https://doi.org/10.1016/j.immuni.2016.08.019