Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health

Autor: Kristine Williams, Germán D. Carrasquilla, Lars Roed Ingerslev, Mette Yde Hochreuter, Svenja Hansson, Nicolas J. Pillon, Ida Donkin, Soetkin Versteyhe, Juleen R. Zierath, Tuomas O. Kilpeläinen, Romain Barrès

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101290- (2021)

Objectives: Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contri

Externí odkaz: https://doaj.org/article/a43dd0005ef848409fc736494902259e

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Autor: Thais de Castro Barbosa, Lars R. Ingerslev, Petter S. Alm, Soetkin Versteyhe, Julie Massart, Morten Rasmussen, Ida Donkin, Rasmus Sjögren, Jonathan M. Mudry, Laurène Vetterli, Shashank Gupta, Anna Krook, Juleen R. Zierath, Romain Barrès

Publikováno v: Molecular Metabolism, Vol 5, Iss 3, Pp 184-197 (2016)

Objectives: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring.

Externí odkaz: https://doaj.org/article/53c3d652fd614af285600d41d39b1dd2

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health

Autor: Romain Barrès, Soetkin Versteyhe, Ida Donkin, Svenja Hansson, Kristine Williams, Lars R. Ingerslev, Tuomas O. Kilpeläinen, Germán D. Carrasquilla, Nicolas J. Pillon, Mette Yde Hochreuter, Juleen R. Zierath

Publikováno v: Williams, K, Carrasquilla, G D, Ingerslev, L R, Hochreuter, M Y, Hansson, S, Pillon, N J, Donkin, I, Versteyhe, S, Zierath, J R, Kilpeläinen, T O & Barrès, R 2021, ' Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health ', Molecular Metabolism, vol. 53, 101290 . https://doi.org/10.1016/j.molmet.2021.101290
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101290-(2021)

Objectives Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47b9bae53632fcb68361a7fbab983ca
https://curis.ku.dk/portal/da/publications/epigenetic-rewiring-of-skeletal-muscle-enhancers-after-exercise-training-supports-a-role-in-the-wholebody-function-and-human-health(83d357b6-a538-4e27-8083-d4d0d6e14a89).html

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Autor: Jonathan M. Mudry, Morten Arendt Rasmussen, Petter S. Alm, Shashank Gupta, Juleen R. Zierath, Romain Barrès, Julie Massart, Rasmus J. O. Sjögren, Lars R. Ingerslev, Thais de Castro Barbosa, Laurène Vetterli, Ida Donkin, Soetkin Versteyhe, Anna Krook

Publikováno v: Molecular Metabolism, Vol 5, Iss 3, Pp 184-197 (2016)
Molecular Metabolism

Objectives Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43b7ab6d408221aac806b6e94e0f509
http://www.sciencedirect.com/science/article/pii/S221287781500232X

DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human

Autor: Soetkin Versteyhe, Jia Liu, Anna Fossum, Romain Barrès, Vibe Nylander, Ida Donkin, David Simar, Luke B. Hesson

Publikováno v: Simar, D, Versteyhe, S, Donkin, I, Liu, J, Hesson, L, Nylander, V C, Fossum, A & Barrès, R 2014, ' DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human ', Metabolism, vol. 63, no. 9 . https://doi.org/10.1016/j.metabol.2014.05.014

Objective Obesity is associated with low-grade inflammation and the infiltration of immune cells in insulin-sensitive tissues, leading to metabolic impairment. Epigenetic mechanisms control immune cell lineage determination, function and migration an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdc7a84fdceb4cf2ee16aeddabf20c5
https://doi.org/10.1016/j.metabol.2014.05.014