Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome

Autor: Hutin, D., Tamblyn, L., Gomez, A., Grimaldi, Giulia, Soedling, H., Cho, T., Ahmed, S., Lucas, C., Kanduri, C., Grant, D.M., Matthews, J.

Yes
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechan

Externí odkaz: http://hdl.handle.net/10454/18338

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Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.

Autor: Hutin D; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Tamblyn L; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Gomez A; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Grimaldi G; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Soedling H; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Cho T; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Ahmed S; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Lucas C; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Kanduri C; Department of Informatics, Jebsen Centre of Excellence for Celiac Disease Research, University of Oslo, Oslo, Norway., Grant DM; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Matthews J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2018 Oct 01; Vol. 165 (2), pp. 347-360.