Zobrazeno 1 - 10
of 2 162
pro vyhledávání: '"Sodium channel blocker"'
Autor:
Avi Sabbag, Gisella Amoroso, Orr Tomer, Giulio Conte, Roy Beinart, Eyal Nof, Tardu Özkartal, Pierre Ollitrault, Mikael Laredo, Oholi Tovia‐Brodie, Estelle Gandjbakhch, Michele deBenedictis, Rachel M. A. terBekke, Anat Milman
Publikováno v:
Journal of Arrhythmia, Vol 40, Iss 4, Pp 982-990 (2024)
Abstract Background Diagnosis of Brugada syndrome (BrS) may be established by exposing a Type 1 Brugada pattern using a sodium channel blocker. Data on the outcomes of different patient populations with drug‐induced Type 1 Brugada pattern are limit
Externí odkaz:
https://doaj.org/article/27eabaa71a8e469d87c14c211fbd30f3
Autor:
Tadafumi Nanbu, Akihiko Yotsukura, George Suzuki, Hiroyuki Takekawa, Yuki Tanaka, Katsuma Yamanashi, Masaya Tsuda, Izumi Yoshida, Masayuki Sakurai, Takashi Ashihara
Publikováno v:
Journal of Arrhythmia, Vol 39, Iss 3, Pp 327-340 (2023)
Abstract Background Rotors are the source of atrial fibrillation (AF). However, the ablation of rotors for persistent AF is challenging. The purpose of this study was to identify the dominant rotor by accelerating the organization of AF using a sodiu
Externí odkaz:
https://doaj.org/article/38c436c23807464f9be19245839e6d4e
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 436-443 (2023)
Abstract Objective Self‐limited infantile epilepsy (SeLIE) has distinctive clinical features, and the PRRT2 gene is known to be a considerable genetic cause. There have been a few studies on PRRT2‐positive SeLIE only, and anti‐seizure medicatio
Externí odkaz:
https://doaj.org/article/cf501b6fc67549cc926ca3a4435a859b
Publikováno v:
International Journal of Arrhythmia, Vol 24, Iss 1, Pp 1-5 (2023)
Abstract Brugada syndrome (BrS) may cause a spectrum of symptoms from asymptomatic patients to those who experience cardiac arrest and sudden cardiac death. The diagnosis is confirmed after observation of type I Brugada pattern on the electrocardiogr
Externí odkaz:
https://doaj.org/article/f98e0faf21284f45bd62e3eb6d2904cb
Autor:
Catharina G. Faber, Nadine Attal, Giuseppe Lauria, Robert H. Dworkin, Roy Freeman, Katherine T. Dawson, Helen Finnigan, Amirhossein Hajihosseini, Himanshu Naik, Michael Serenko, Christopher J. Morris, Mona Kotecha
Publikováno v:
EClinicalMedicine, Vol 59, Iss , Pp 101971- (2023)
Summary: Background: No pharmacological treatments are specifically indicated for painful small fibre neuropathy (SFN). CONVEY, a phase 2 enriched-enrolment study, evaluated the efficacy and safety of vixotrigine, a voltage- and use-dependent sodium
Externí odkaz:
https://doaj.org/article/98dd54c83e884b6a959fad1b27b55fcf
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15423- (2023)
The sodium channel Nav1.9 is expressed in the sensory neurons of small diameter dorsal root ganglia that transmit pain signals, and gain-of-function Nav1.9 mutations have been associated with both painful and painless disorders. We initially determin
Externí odkaz:
https://doaj.org/article/82426671ec4a4a4290cc25e577c21d7f
Akademický článek
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Akademický článek
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Publikováno v:
Clocks & Sleep, Vol 3, Iss 3, Pp 351-365 (2021)
Dysregulated circadian functions contribute to various diseases, including cardiovascular disease. Much progress has been made on chronotherapeutic applications of drugs against cardiovascular disease (CVD); however, the direct effects of various med
Externí odkaz:
https://doaj.org/article/5ae9394dac144653bec8580e346ff354
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveVoltage-gated sodium channels (VGSCs) play an important role in neuronal excitability and epilepsies. In addition to the brain, VGSCs are also abundant enriched in cardiac tissues and are responsible for normal cardiac rhythm. Theoretically,
Externí odkaz:
https://doaj.org/article/00c7d8b44b634378b791c246abb7074c