Výsledky vyhledávání - "Sodium Bicarbonate/pharmacology"

Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies

Autor: Nicolas Demartines, Tania Santoro, Seraina Faes, Olivier Dormond, Emilie Uldry, Anne Planche, Catherine Pythoud

Publikováno v: Oncotarget
Oncotarget, vol. 7, no. 52, pp. 86026-86038

// Seraina Faes 1 , Emilie Uldry 1 , Anne Planche 1 , Tania Santoro 1 , Catherine Pythoud 1 , Nicolas Demartines 1 , Olivier Dormond 1 1 Department of Visceral Surgery, University Hospital of Lausanne, Switzerland Correspondence to: Olivier Dormond,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f8439a88d690826077147dfb4e3b72
https://pubmed.ncbi.nlm.nih.gov/27852069

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Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors

Autor: Seraina Faes, Catherine Pythoud, Janine Horlbeck, Nicolas Demartines, Nicolo Riggi, Emilie Uldry, Tania Santoro, Igor Letovanec, Olivier Dormond, Jean-Christophe Stehle, Adrian P. Duval, Anne Planche

Publikováno v: Molecular Cancer
Molecular cancer, vol. 15, no. 1, pp. 78
Europe PubMed Central

Background: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a38040ac493a5b66950be7aa66951c
https://pubmed.ncbi.nlm.nih.gov/27919264

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Maximal lactic capacity at altitude: effect of bicarbonate loading

Autor: P. Cerretelli, Tiziano Binzoni, B. Grassi, Bengt Kayser, Guido Ferretti

Publikováno v: Journal of Applied Physiology: Respiratory, Environmental & Exercise Physiology, Vol. 75, No 3 (1993) pp. 1070-1074
Europe PubMed Central
Scopus-Elsevier

The aim of the present study was to test the hypothesis that the net maximal blood lactate accumulation ([La]max) during heavy exercise in lowlanders acclimatized to chronic hypoxia may be limited by the reduced bicarbonate stores. Six men [age 32 +/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e822993a670a1dc4aae56b469aed79c
https://archive-ouverte.unige.ch/unige:10311

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