Varicose veins of lower extremities: Insights from the first large-scale genetic study.

Autor: Alexandra S Shadrina, Sodbo Z Sharapov, Tatiana I Shashkova, Yakov A Tsepilov

Publikováno v: PLoS Genetics, Vol 15, Iss 4, p e1008110 (2019)

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data

Externí odkaz: https://doaj.org/article/318cf3e8c09d4d02bf3a0a2f3a94c557

Mapping of the gene network that regulates glycan clock of ageing

Autor: Azra Frkatović-Hodžić, Karlo Miškec, Anika Mijakovac, Arina Nostaeva, Sodbo Z. Sharapov, Arianna Landini, Toomas Haller, Erik van den Akker, Sapna Sharma, Rafael R. C. Cuadrat, Massimo Mangino, Yong Li, Toma Keser, Najda Rudman, Tamara Štambuk, Maja Pučić-Baković, Irena Trbojević-Akmačić, Ivan Gudelj, Jerko Štambuk, Tea Pribić, Barbara Radovani, Petra Tominac, Krista Fischer, Marian Beekman, Manfred Wuhrer, Christian Gieger, Matthias B. Schulze, Clemens Wittenbecher, Ozren Polasek, Caroline Hayward, James F. Wilson, Tim D. Spector, Anna Köttgen, Frano Vučković, Yurii S. Aulchenko, Aleksandar Vojta, Jasminka Krištić, Lucija Klarić, Vlatka Zoldoš, Gordan Lauc

Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d92d3302502fc9912a10a4d1815f33e6
https://doi.org/10.1101/2023.04.25.23289027

Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins

Autor: Artemii A, Ivanov, Egor A, Ukladov, Stepan A, Kremis, Sodbo Z, Sharapov, Sergey I, Baiborodin, Alla V, Lipeeva, Elvira E, Shults, Tatiana S, Golubeva

Publikováno v: Protoplasma. 259(5)

High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59d71013d5095b313141b5f957fcc72e
https://pubmed.ncbi.nlm.nih.gov/35080665

Genetic regulation of post-translational modification of two distinct proteins

Autor: Arianna Landini, Irena Trbojević-Akmačić, Pau Navarro, Yakov A. Tsepilov, Sodbo Z. Sharapov, Frano Vučković, Ozren Polašek, Caroline Hayward, Tea Petrović, Marija Vilaj, Yurii S. Aulchenko, Gordan Lauc, James F. Wilson, Lucija Klarić

Publikováno v: Nature Communications
Landini, A, Trbojević-Akmačić, I, Navarro, P, Tsepilov, Y A, Sharapov, S Z, Vučković, F, Polašek, O, Hayward, C, Petrović, T, Vilaj, M, Aulchenko, Y S, Lauc, G, Wilson, J F & Klarić, L 2022, ' Genetic regulation of post-translational modification of two distinct proteins ', Nature Communications, vol. 13, no. 1, 1586, pp. 1586 . https://doi.org/10.1038/s41467-022-29189-5

Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic regulation or influence on complex traits is not fully underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea1e1575a36a47290bbd4e4e163147c