Measurement of CYP1A2 and CYP3A4 activity by a simplified Geneva cocktail approach in a cohort of free-living individuals: a pilot study.

Autor: Sobsey CA; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada., Mady N; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Peter Brojde Lung Cancer Centre, Jewish General Hospital, Montreal, QC, Canada., Richard VR; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., LeBlanc A; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., Zakharov T; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Peter Brojde Lung Cancer Centre, Jewish General Hospital, Montreal, QC, Canada., Borchers CH; Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada., Jagoe RT; Peter Brojde Lung Cancer Centre, Jewish General Hospital, Montreal, QC, Canada.; Department of Medicine, Jewish General Hospital, Montreal, QC, Canada.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Feb 02; Vol. 15, pp. 1232595. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).

A multiplexed, automated immuno-matrix assisted laser desorption/ionization mass spectrometry assay for simultaneous and precise quantitation of PTEN and p110α in cell lines and tumor tissues.

Autor: Froehlich BC; University of Victoria - Genome BC Proteomics Centre, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8P 5C2, Canada., Popp R; University of Victoria - Genome BC Proteomics Centre, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada., Sobsey CA; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Ibrahim S; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., LeBlanc A; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Mohammed Y; University of Victoria - Genome BC Proteomics Centre, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada.; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia., Buchanan M; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Aguilar-Mahecha A; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Pötz O; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen 72770, Germany.; SIGNATOPE GmbH, Reutlingen 72770, Germany., Chen MX; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Spatz A; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Basik M; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada., Batist G; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada.; Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC H4A3T2, Canada. christoph.borchers@mcgill.ca., Zahedi RP; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia., Borchers CH; University of Victoria - Genome BC Proteomics Centre, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T1E2, Canada.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia.; Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC H4A3T2, Canada. christoph.borchers@mcgill.ca.

Publikováno v: The Analyst [Analyst] 2021 Oct 25; Vol. 146 (21), pp. 6566-6575. Date of Electronic Publication: 2021 Oct 25.

Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells.

Autor: Froehlich BC; University of Victoria-Genome BC Proteomics Centre, University of Victoria, Victoria, BC, V8Z 7E8, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C2, Canada., Popp R; University of Victoria-Genome BC Proteomics Centre, University of Victoria, Victoria, BC, V8Z 7E8, Canada., Sobsey CA; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., Ibrahim S; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., LeBlanc AM; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., Mohammed Y; University of Victoria-Genome BC Proteomics Centre, University of Victoria, Victoria, BC, V8Z 7E8, Canada.; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow, 121205, Russia., Aguilar-Mahecha A; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., Poetz O; NMI Natural and Medical Sciences Institute University of Tuebingen, Reutlingen, 72770, Germany.; SIGNATOPE GmbH, Reutlingen, 72770, Germany., Chen MX; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Spatz A; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., Basik M; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada., Batist G; Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada.; Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC, H4A3T2, Canada., Zahedi RP; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow, 121205, Russia., Borchers CH; University of Victoria-Genome BC Proteomics Centre, University of Victoria, Victoria, BC, V8Z 7E8, Canada.; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, H3T1E2, Canada.; Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC, H4A3T2, Canada.; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow, 121205, Russia.

Publikováno v: Proteomics. Clinical applications [Proteomics Clin Appl] 2020 Sep; Vol. 14 (5), pp. e2000034. Date of Electronic Publication: 2020 Aug 09.

Development and evaluation of a liquid chromatography-mass spectrometry method for rapid, accurate quantitation of malondialdehyde in human plasma.

Autor: Sobsey CA; University of Victoria-Genome BC Proteomics Centre, Vancouver Island Technology Park, 3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada; Department of Biochemistry and Microbiology, University of Victoria, Petch Building Room 207, 3800 Finnerty Road, Victoria, BC V8P 5C2, Canada., Han J; University of Victoria-Genome BC Proteomics Centre, Vancouver Island Technology Park, 3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada., Lin K; University of Victoria-Genome BC Proteomics Centre, Vancouver Island Technology Park, 3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada., Swardfager W; Pharmacology and Toxicology Department, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada., Levitt A; Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada., Borchers CH; University of Victoria-Genome BC Proteomics Centre, Vancouver Island Technology Park, 3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada; Department of Biochemistry and Microbiology, University of Victoria, Petch Building Room 207, 3800 Finnerty Road, Victoria, BC V8P 5C2, Canada; Segal Cancer Centre, Jewish General Hospital, McGill University, 3755 Cote Ste-Catherine Road, Montreal, QC H3T 1E2, Canada. Electronic address: christoph@proteincentre.com.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2016 Sep 01; Vol. 1029-1030, pp. 205-212. Date of Electronic Publication: 2016 Jul 07.

HMDB: a knowledgebase for the human metabolome.

Autor: Wishart DS; Department of Computing Science, Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E8. david.wishart@ualberta.ca, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2009 Jan; Vol. 37 (Database issue), pp. D603-10. Date of Electronic Publication: 2008 Oct 25.