Multiscale mapping of transcriptomic signatures for cardiotoxic drugs.

Autor: Hansen J; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. jens.hansen@mssm.edu.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. jens.hansen@mssm.edu., Xiong Y; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Siddiq MM; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Dhanan P; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hu B; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shewale B; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Yadaw AS; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Jayaraman G; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tolentino RE; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chen Y; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Martinez P; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Beaumont KG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Vidovic D; Institute for Data Science and Computing, University of Miami, Coral Gables, FL, 33146, USA., Schürer SC; Institute for Data Science and Computing, University of Miami, Coral Gables, FL, 33146, USA., Goldfarb J; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Gallo JM; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; School of Pharmacy and Pharmaceutical Sciences, University of Buffalo SUNY System, Buffalo, NY, 14260, USA., Birtwistle MR; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, 29634, USA., Sobie EA; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Azeloglu EU; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New, York, NY, 10029, USA., Berger SI; Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, 20012, USA., Chan A; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Cardiology Division, Department of Medicine, Memorial Sloan Kettering Cancer Center New York, New York, NY, 10065, USA., Schaniel C; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Dubois NC; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Dubois@mssm.edu.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Dubois@mssm.edu., Iyengar R; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ravi.iyengar@mssm.edu.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ravi.iyengar@mssm.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 11; Vol. 15 (1), pp. 7968. Date of Electronic Publication: 2024 Sep 11.

HRAS -Mutant Cardiomyocyte Model of Multifocal Atrial Tachycardia.

Autor: Rodríguez NA; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY., Patel N; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY., Dariolli R; Department of Pharmacological Sciences & Systems Biology Center New York (R.D., J.Q.X.G., E.A.S.), Icahn School of Medicine at Mount Sinai, New York, NY., Ng S; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY., Aleman AG; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY., Gong JQX; Department of Pharmacological Sciences & Systems Biology Center New York (R.D., J.Q.X.G., E.A.S.), Icahn School of Medicine at Mount Sinai, New York, NY., Lin HM; Yale Center for Analytical Sciences (YCAS), New Haven, CT (H.-M.L.)., Rodríguez M; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY., Josowitz R; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA (R.J.)., Sol-Church K; Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA (K.S.-C.)., Gripp KW; Division of Medical Genetics; Al duPont Hospital for Children/Nemours, Wilmington, DE (K.W.G.)., Lin X; Leon H. Charney Division of Cardiology, New York University School of Medicine (X.L., G.I.F.)., Song SC; Ion Lab, Department of Pathology, NYU Langone Health, New York, NY (S.C.S.)., Fishman GI; Leon H. Charney Division of Cardiology, New York University School of Medicine (X.L., G.I.F.)., Sobie EA; Department of Pharmacological Sciences & Systems Biology Center New York (R.D., J.Q.X.G., E.A.S.), Icahn School of Medicine at Mount Sinai, New York, NY., Gelb BD; Mindich Child Health & Development Institute (N.A.R., N.P., S.N., A.G.A., M.R., B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY.; Division of Pediatric Cardiology, Department of Pediatrics (B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY.; Department of Genetics and Genomic Sciences (B.D.G.), Icahn School of Medicine at Mount Sinai, New York, NY.

Publikováno v: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2024 Apr; Vol. 17 (4), pp. e012022. Date of Electronic Publication: 2024 Feb 28.

Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors.

Autor: Shim JV; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Xiong Y; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Dhanan P; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Dariolli R; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Azeloglu EU; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Hu B; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Jayaraman G; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Schaniel C; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Birtwistle MR; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Iyengar R; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Dubois NC; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Sobie EA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Apr 10; Vol. 14, pp. 1158222. Date of Electronic Publication: 2023 Apr 10 (Print Publication: 2023).

Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation.

Autor: Muñoz JJAM; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil.; Universidad Señor de Sipán, Chiclayo, Perú., Dariolli R; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil.; Department of Pharmacological Sciences, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., da Silva CM; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Neri EA; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Valadão IC; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Turaça LT; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Lima VM; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., de Carvalho MLP; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Velho MR; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil., Sobie EA; Department of Pharmacological Sciences, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krieger JE; Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Eneas C. Aguiar 44, São Paulo, SP, 05403-000, Brazil. j.krieger@hc.fm.usp.br.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2022 Sep 02; Vol. 13 (1), pp. 437. Date of Electronic Publication: 2022 Sep 02.

PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

Autor: Wickramasinghe NM; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sachs D; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Shewale B; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gonzalez DM; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dhanan-Krishnan P; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Torre D; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., LaMarca E; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Raimo S; Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA., Dariolli R; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Serasinghe MN; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mayourian J; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Beaumont K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Iyengar S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., French DL; Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA., Hansen A; University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Eschenhagen T; University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany., Chipuk JE; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sobie EA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jacobs A; Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Akbarian S; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ischiropoulos H; Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA., Ma'ayan A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Houten SM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Costa K; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dubois NC; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nicole.dubois@mssm.edu.

Publikováno v: Cell stem cell [Cell Stem Cell] 2022 Apr 07; Vol. 29 (4), pp. 559-576.e7. Date of Electronic Publication: 2022 Mar 23.