Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sobel Leonard, A"'
Influenza A virus is a major source of morbidity and mortality, annually resulting in over 9000 deaths in the United States alone. As a segmented, RNA virus, influenza has a high mutation rate, facilitating its evolution to overcome cross protective
Externí odkaz:
http://hdl.handle.net/10161/13395
Autor:
Andrew D. Marques, Jevon Graham-Wooten, Ayannah S. Fitzgerald, Ashley Sobel Leonard, Emma J. Cook, John K. Everett, Kyle G. Rodino, Louise H. Moncla, Brendan J. Kelly, Ronald G. Collman, Frederic D. Bushman
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunocompromised patients provides an opportunity for viral evolution, potentially leading to the generation of new pathogenic variants. To investigate
Externí odkaz:
https://doaj.org/article/e8eba7dc67e744768c3e726f093b56ee
Autor:
Melissa B Manus, Gerald S Bloomfield, Ashley Sobel Leonard, Laura N Guidera, David R Samson, Charles L Nunn
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201616 (2018)
Elevated blood pressure presents a global health threat, with rates of hypertension increasing in low and middle-income countries. Lifestyle changes may be an important driver of these increases in blood pressure. Hypertension is particularly prevale
Externí odkaz:
https://doaj.org/article/194bdf4b95fb48bcadc68bcd263e7668
Autor:
Ashley Sobel Leonard, Micah T McClain, Gavin J D Smith, David E Wentworth, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, Suman R Das, Anthony S Gilbert, Rob Lambkin-Williams, Geoffrey S Ginsburg, Christopher W Woods, Katia Koelle, Christopher J R Illingworth
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006203 (2017)
We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts. Changes in t
Externí odkaz:
https://doaj.org/article/fadec62abb5444fe9355d76d7e1976f5
Autor:
Sobel Leonard, Ashley1, McClain, Micah T.2, Smith, Gavin J. D.3, Wentworth, David E.4, Halpin, Rebecca A.4, Lin, Xudong4 chris.illingworth@gen.cam.ac.uk, Ransier, Amy4, Stockwell, Timothy B.4, Das, Suman R.4, Gilbert, Anthony S.5, Lambkin-Williams, Rob5, Ginsburg, Geoffrey S.2, Woods, Christopher W.2, Koelle, Katia1, Illingworth, Christopher J. R.6,7
Publikováno v:
PLoS Pathogens. 2/7/2017, Vol. 13 Issue 2, p1-26. 26p.
Autor:
Timothy B. Stockwell, Micah T. McClain, Amy Ransier, Katia Koelle, Christopher W. Woods, Rebecca A. Halpin, Gavin J. D. Smith, Anthony Gilbert, Suman R. Das, Xudong Lin, Ashley Sobel Leonard, Geoffrey S. Ginsburg, Rob Lambkin-Williams, David E. Wentworth
Publikováno v:
Journal of Virology
Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9ed861eab3672c772939fc3bcf9204
https://doi.org/10.1128/jvi.01657-16
https://doi.org/10.1128/jvi.01657-16
Publikováno v:
Journal of Virology
The bottleneck governing infectious disease transmission describes the size of the pathogen population transferred from the donor to the recipient host. Accurate quantification of the bottleneck size is particularly important for rapidly evolving pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245f0620b86734113c59d9a01ed13a12
http://europepmc.org/articles/PMC6694826
http://europepmc.org/articles/PMC6694826
Autor:
Laura N. Guidera, Gerald S. Bloomfield, Ashley Sobel Leonard, Charles L. Nunn, David R. Samson, Melissa B. Manus
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0201616 (2018)
PLoS ONE, Vol 13, Iss 8, p e0201616 (2018)
Elevated blood pressure presents a global health threat, with rates of hypertension increasing in low and middle-income countries. Lifestyle changes may be an important driver of these increases in blood pressure. Hypertension is particularly prevale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86af5d96e21b7a55941ea68fdfea3228
https://pubmed.ncbi.nlm.nih.gov/30114223
https://pubmed.ncbi.nlm.nih.gov/30114223
Publikováno v:
Journal of Virology. 91
The bottleneck governing infectious disease transmission describes the size of the pathogen population transferred from a donor to a recipient host. Accurate quantification of the bottleneck size is of particular importance for rapidly evolving patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd10e31864ef8d96711001922f4fc2d
https://doi.org/10.1128/jvi.00171-17
https://doi.org/10.1128/jvi.00171-17
Autor:
Sobel Leonard, Ashley1, Weissman, Daniel B.2, Greenbaum, Benjamin3, Ghedin, Elodie4, Koelle, Katia1 katia.koelle@duke.edu
Publikováno v:
Journal of Virology. Jul2017, Vol. 91 Issue 14, p1-19. 19p.