Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Sobel Leonard, A"'
Publikováno v:
Journal of Virology
The bottleneck governing infectious disease transmission describes the size of the pathogen population transferred from the donor to the recipient host. Accurate quantification of the bottleneck size is particularly important for rapidly evolving pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245f0620b86734113c59d9a01ed13a12
http://europepmc.org/articles/PMC6694826
http://europepmc.org/articles/PMC6694826
Autor:
Andrew D. Marques, Jevon Graham-Wooten, Ayannah S. Fitzgerald, Ashley Sobel Leonard, Emma J. Cook, John K. Everett, Kyle G. Rodino, Louise H. Moncla, Brendan J. Kelly, Ronald G. Collman, Frederic D. Bushman
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunocompromised patients provides an opportunity for viral evolution, potentially leading to the generation of new pathogenic variants. To investigate
Externí odkaz:
https://doaj.org/article/e8eba7dc67e744768c3e726f093b56ee
Autor:
Sobel Leonard A; Division of Infectious Diseases, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Mendoza L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., McFarland AG; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Marques AD; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Everett JK; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Moncla L; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, PA 19104, USA., Bushman FD; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Odom John AR; Division of Infectious Diseases, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA., Hensley SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.
Publikováno v:
Virus evolution [Virus Evol] 2024 Apr 25; Vol. 10 (1), pp. veae034. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024).
Autor:
Marques AD; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Graham-Wooten J; Division of Pulmonary, Allergy, and Critical Care, Philadelphia, Pennsylvania, USA., Fitzgerald AS; Division of Pulmonary, Allergy, and Critical Care, Philadelphia, Pennsylvania, USA., Sobel Leonard A; Division of Infectious Diseases, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cook EJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Everett JK; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Rodino KG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Moncla LH; Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kelly BJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Collman RG; Division of Pulmonary, Allergy, and Critical Care, Philadelphia, Pennsylvania, USA., Bushman FD; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Publikováno v:
MBio [mBio] 2024 Mar 13; Vol. 15 (3), pp. e0011024. Date of Electronic Publication: 2024 Feb 16.
Publikováno v:
Journal of Virology. Sep2019, Vol. 93 Issue 17, p1-1. 1p.
Autor:
Melissa B Manus, Gerald S Bloomfield, Ashley Sobel Leonard, Laura N Guidera, David R Samson, Charles L Nunn
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201616 (2018)
Elevated blood pressure presents a global health threat, with rates of hypertension increasing in low and middle-income countries. Lifestyle changes may be an important driver of these increases in blood pressure. Hypertension is particularly prevale
Externí odkaz:
https://doaj.org/article/194bdf4b95fb48bcadc68bcd263e7668
Autor:
Ashley Sobel Leonard, Micah T McClain, Gavin J D Smith, David E Wentworth, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, Suman R Das, Anthony S Gilbert, Rob Lambkin-Williams, Geoffrey S Ginsburg, Christopher W Woods, Katia Koelle, Christopher J R Illingworth
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006203 (2017)
We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts. Changes in t
Externí odkaz:
https://doaj.org/article/fadec62abb5444fe9355d76d7e1976f5
Influenza A virus is a major source of morbidity and mortality, annually resulting in over 9000 deaths in the United States alone. As a segmented, RNA virus, influenza has a high mutation rate, facilitating its evolution to overcome cross protective
Externí odkaz:
http://hdl.handle.net/10161/13395
Autor:
Sobel Leonard, Ashley1, McClain, Micah T.2, Smith, Gavin J. D.3, Wentworth, David E.4, Halpin, Rebecca A.4, Lin, Xudong4 chris.illingworth@gen.cam.ac.uk, Ransier, Amy4, Stockwell, Timothy B.4, Das, Suman R.4, Gilbert, Anthony S.5, Lambkin-Williams, Rob5, Ginsburg, Geoffrey S.2, Woods, Christopher W.2, Koelle, Katia1, Illingworth, Christopher J. R.6,7
Publikováno v:
PLoS Pathogens. 2/7/2017, Vol. 13 Issue 2, p1-26. 26p.
Autor:
Timothy B. Stockwell, Micah T. McClain, Amy Ransier, Katia Koelle, Christopher W. Woods, Rebecca A. Halpin, Gavin J. D. Smith, Anthony Gilbert, Suman R. Das, Xudong Lin, Ashley Sobel Leonard, Geoffrey S. Ginsburg, Rob Lambkin-Williams, David E. Wentworth
Publikováno v:
Journal of Virology
Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9ed861eab3672c772939fc3bcf9204
https://doi.org/10.1128/jvi.01657-16
https://doi.org/10.1128/jvi.01657-16