NDE1 and NDEL1: twin neurodevelopmental proteins with similar ‘nature’ but different ‘nurture’

Autor: Bradshaw Nicholas J., Hennah William, Soares Dinesh C.

Publikováno v: Biomolecular Concepts, Vol 4, Iss 5, Pp 447-464 (2013)

Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. The tw

Externí odkaz: https://doaj.org/article/7cf4474b27504d6f892dcebe697d2299

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Autor: Johnston, Chris J.C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P.J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Johnston, C J C, Smyth, D J, Kodali, R B, White, M P J, Harcus, Y, Filbey, K J, Hewitson, J P, Hinck, C S, Ivens, A, Kemter, A M, Kildemoes, A O, Le Bihan, T, Soares, D C, Anderton, S M, Brenn, T, Wigmore, S J, Woodcock, H V, Chambers, R C, Hinck, A P, Mcsorley, H J & Maizels, R M 2017, ' A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells ', Nature Communications, vol. 8, no. 1, 1741 . https://doi.org/10.1038/s41467-017-01886-6
Johnston, C J C, Smyth, D, Kodali, R B, White, M P J, Harcus, Y, Filbey, K J, Hewitson, J P, Hinck, C S, Ivens, A, Kemter, A M, Kildemoes, A O, Le Bihan, T, Soares, D, Anderton, S M, Brenn, T, Wigmore, S J, Woodcock, H, Chambers, R C, Hinck, A P, McSorley, H J & Maizels, R 2017, ' A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells ', Nature Communications, vol. 8, 1741 . https://doi.org/10.1038/s41467-017-01886-6

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e8a8762c6aa5a0b05c9a9e2fb69eba2b
https://doaj.org/article/8966a9c3f97c4921a792b74844b1800f

Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability

Autor: Lam, Wayne W.K., Millichap, John J., Soares, Dinesh C., Chin, Richard, McLellan, Ailsa, FitzPatrick, David R., Elmslie, Frances, Lees, Melissa M., Schaefer, G. Bradley, Abbott, Catherine M.

Publikováno v: Molecular Genetics & Genomic Medicine

Background Exome sequencing has led to the discovery of mutations in novel causative genes for epilepsy. One such gene is EEF1A2, encoding a neuromuscular specific translation elongation factor, which has been found to be mutated de novo in five case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86ccc3e4183bdd7333ba6ee124f91552
http://europepmc.org/articles/PMC4947865

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

RPGR: Its role in photoreceptor physiology, human disease, and future therapies

Autor: Megaw, Roly D., Soares, Dinesh C., Wright, Alan F.

Publikováno v: Experimental Eye Research. 138:32-41

Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS) to the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary proteins are a common cause of the inherited retinal dystrophy retin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::875575aafda7bfc7244aa08b233d5d09