Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Soan Cheng"'
Autor:
April M Weissmiller, Orlangie Natera-Naranjo, Sol M Reyna, Matthew L Pearn, Xiaobei Zhao, Phuong Nguyen, Soan Cheng, Lawrence S B Goldstein, Rudolph E Tanzi, Steven L Wagner, William C Mobley, Chengbiao Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (
Externí odkaz:
https://doaj.org/article/67d94cb4c74847f09dd63eb7f1a20f27
Autor:
Jutta Glock, Peter D. J. Grootenhuis, Steven Bondy, Daniel D. Comer, Soan Cheng, Arthur Steiger, Martin Zeller, Grit Laue, Adrian Friedmann, Olivier Jacob, Mafalda Nina, Hans-Jürg Widmer, Klaus Kreuz, Julie E. Penzotti, Hans Brunner, James Allen, Thierry Niderman, Hans Ulrich Haas, Renold Chollet, Martin Eberle, Peter Renold, William Lutz, Jürg Ehrler, Marian Valentini, Markus Walti, Evelyne Sieger, Thomas Vettiger, G. Wayne Craig
Publikováno v:
CHIMIA, Vol 62, Iss 1-2 (2008)
The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry of a biological hit discovered in the screening system of Novartis Crop Prote
Externí odkaz:
https://doaj.org/article/5c120d9f6ae7458abd6d1d641fce6442
Autor:
Soan Cheng, Sangram S. Sisodia, Yue-Ming Li, Xulun Zhang, Rudolph E. Tanzi, Phuong Nguyen, Can Zhang, Steven L. Wagner, Kevin D. Rynearson, Rong Wang, William C. Mobley
Publikováno v:
Biochemistry
Biochemistry, vol 53, iss 4
Biochemistry, vol 53, iss 4
Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring m
Autor:
William C. Mobley, April M. Weissmiller, Soan Cheng, Lawrence S.B. Goldstein, Xiaobei Zhao, Phuong Nguyen, Rudolph E. Tanzi, Matthew L. Pearn, Steven L. Wagner, Orlangie Natera-Naranjo, Sol M. Reyna, Chengbiao Wu
Publikováno v:
PLoS ONE
PloS one, vol 10, iss 2
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
PloS one, vol 10, iss 2
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (
Publikováno v:
Tetrahedron Letters. 40:8975-8978
Liquid phase parallel synthesis has been developed to synthesize a novel series of iminodiacetic acid derivatives targeting the integrin receptors. This library was synthesized using a four-step reaction sequence. In each step of the sequence, the PE
Publikováno v:
Journal of the American Chemical Society. 118:2567-2573
A simple, versatile, and general approach to the solution phase, parallel synthesis of chemical libraries conducted on a generalized or universal template, which allows the preparation of multi-mil...
Publikováno v:
Biopolymers. 37:157-175
The cell adhesion domain, arginine-glycine-aspartic acid (RGD), has been incorporated into synthetic peptides to perform either of two modes of drug action, antagonist or agonist. Short, conformationally constrained peptides have been developed as an
Autor:
Michael D. Pierschbacher, Juerg F. Tschopp, Soan Cheng, Daniel G. Mullen, Doug Dixon, William S. Craig
Publikováno v:
Journal of Medicinal Chemistry. 37:1-8
Utilizing conformational constraints in conjunction with various structural considerations, we have synthesized a series of cyclic disulfide peptides that are highly potent and selective antagonists for the platelet integrin alpha IIb beta 3 (GPIIb/I
Autor:
Soan Cheng, Daniel D. Comer
Publikováno v:
Tetrahedron Letters. 43:1179-1181
A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2,5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offe
Autor:
Sangram S. Sisodia, Rudolph E. Tanzi, Chengzhi Yu, Anne M. Danks, Soan Cheng, Gonul Velicelebi, Kenneth A. Stauderman, Kwangwook Ahn, Yue-Ming Li, Elizabeth J. Ackerman, Dan Comer, Paul J. Digregorio, Phuong T. Nguyen, William T. Comer, Long Mao, David P. M. Pleynet, Xulun Zhang, Maria Z. Kounnas, Steven L. Wagner, William C. Mobley, Curtis M. Tyree
Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta(42) levels without inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0cce1c4de406c2d5b743c7ab53d04
https://europepmc.org/articles/PMC2947312/
https://europepmc.org/articles/PMC2947312/