Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Soad A. El-Hawash"'
Autor:
Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Dabees, Ahmed E. Abdel Moneim, Ibrahim A. Abdel Wahab, Mohammad M. Abd-Alhaseeb, Mostafa M. M. El-Miligy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1737-1751 (2022)
A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dua
Externí odkaz:
https://doaj.org/article/09f1914e14b8496fbcf7c84b641248cb
Autor:
Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Daabees, Ahmed E. Abdel Moneim, Mostafa M. M. El-Miligy
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1165 (2022)
New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds 6b and 6j showed higher in vitro COX-2 selectivity and inhibitory activity (IC50 = 0.04 µM and S
Externí odkaz:
https://doaj.org/article/16314089b06f4edc993ae0c921a54ade
Autor:
Rasha M. Allam, Rana Alaaeddine, Hoda G. Daabees, Ali H. Eid, Ahmed F. El-Yazbi, Perihan A. Elzahhar, Andrea Angeli, Claudiu T. Supuran, Rehab Hegazy, Bahaa El-Dien M. El-Gendy, Maged W. Helmy, Soad A.M. El-Hawash, Shrouk M. Abd El Wahab, Ahmed S.F. Belal, Mohamed Elagawany
Publikováno v:
European journal of medicinal chemistry. 200
Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticance
Autor:
Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Rasha Y. Elbayaa, Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Omaima G. Shaaban, Nargues S. Habib
Publikováno v:
Bioorganic Chemistry. 76:437-448
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w
Autor:
Alaa A. El-Tombary, Perihan A. Elzahhar, Ibrahim M. El-Ashmawy, Salwa Elkazaz, Soad A.M. El-Hawash, Hossam A. Shaltout, Abeer E. Abdel Wahab, Raafat Soliman
Publikováno v:
Future Medicinal Chemistry. 9:1413-1450
Aim: Inflammation may cause accumulation of fluid in the injured area, which may promote bacterial growth. Other reports disclosed that non-steroidal anti-inflammatory drugs may enhance progression of bacterial infection. Results: This work describes
Autor:
Soad Am El Hawash, Ashraf M Omar, Maha A El Demellawy, Abeer E. Abdel Wahab, Maryam A.Z. El-Attar, Heba A. Abd El Razik, Aly A. Hazzaa
Publikováno v:
Future medicinal chemistry. 11(13)
Aim: Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Materials & methods: Sulfanylpyrimidines and triazolopyrimidines were synthesized and evaluated as anticancer and antioxidant COX-1/2 inh
Autor:
Dharmarajan Sriram, Yasser S. Abdel-Ghany, Perihan A. Elzahhar, Soad A.M. El-Hawash, Rasha A. Nassra, Manal N. S. Saudi, Nayera W. Hassan, Marwa M. Abdel-Aziz, Azza Ismail
Publikováno v:
Bioorganic Chemistry. 96:103610
TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moiet
Autor:
Soad A.M. El-Hawash, Rasha A. Nassra, Perihan M. Elzahhar, Marwa M. Abu-Serie, Ahmed S.F. Belal
Publikováno v:
Proceedings of 4th International Electronic Conference on Medicinal Chemistry.
Autor:
Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Nargues S. Habib, Omaima G. Shaaban, Rasha Y. Elbayaa
Publikováno v:
Future medicinal chemistry. 10(18)
Aim: The development of a new class of antimicrobial agents is the optimal lifeline to scrap the escalating jeopardy of drug resistance. Experimental: This study aims to design and synthesize a series of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines, to
Autor:
Soad A.M. El-Hawash, Rasha A. Nassra, Mostafa M.M. El-Miligy, Hanan El-Messmary, Aly A. Hazzaa
Publikováno v:
Future medicinal chemistry. 9(5)
Aim: Simultaneous inhibition of 5-LOX/COX may enhance anti-inflammatory effects and reduce side effects. Hence, synthesis of novel dual inhibitors of 5-LOX/COX is an important strategy for treatment of inflammation. Results/methodology: The target co