Zobrazeno 1 - 10
of 1 381
pro vyhledávání: '"So-mi Kang"'
Autor:
Soyoung Park, Ah-Young Oh, Byung-Su Hong, Yun-Jeong Shin, Hyewon Jang, Hyunghwan Seo, So-mi Kang, Tae-Gyun Woo, Hyo-Pin Park, Jiwon Jeong, Hye-Ju Kim, Bae-Hoon Kim, Yonghoon Kwon, Bum-Joon Park
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200875- (2024)
Alternative splicing products of AIMP2 and AIMP2-DX2 (DX2) have been reported to be associated with human lung cancer. In fact, DX2 expression is elevated in human lung cancers, and DX2 transgenic mice also develop lung cancer, in particular small ce
Externí odkaz:
https://doaj.org/article/a5fa691b220b414c9aa0ec67c586113d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Increased hydrophobicity identified by the crystal structure presented in this work suggests a mechanism by which the S143F form of lamin A/C leads to progeria, a rapid aging syndrome. The authors observed aberrant molecular interactions that appear
Externí odkaz:
https://doaj.org/article/0720ca4774fc4f8f98266476fb503150
Publikováno v:
Cells, Vol 12, Iss 18, p 2299 (2023)
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused by the mutant protein progerin, which is expressed by the abnormal splicing of the LMNA gene. HGPS affects systemic levels, with the exception of cognition or
Externí odkaz:
https://doaj.org/article/9758cbf21f0e476ba0806b433453a984
Autor:
Tae-Gyun Woo, Min-Ho Yoon, So-mi Kang, Soyoung Park, Jung-Hyun Cho, Young Jun Hwang, Jinsook Ahn, Hyewon Jang, Yun-Jeong Shin, Eui-Man Jung, Nam-Chul Ha, Bae-Hoon Kim, Yonghoon Kwon, Bum-Joon Park
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
With ELISA-based screening, Woo et al. identify a new small molecule, PRG-A01, which can block the misfolding/aggregation of SOD1 or TDP-43 in a human neuroblastoma cell line. Its use in a mouse model of ALS results in improvement of muscle strength,
Externí odkaz:
https://doaj.org/article/f1e4045faeb04055bfa9700b0679930b
Autor:
So-mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late
Externí odkaz:
https://doaj.org/article/01b8eaca40fd400584abe15784946828
Autor:
So-mi Kang, Seungwoon Seo, Eun Ju Song, Okhee Kweon, Ah-hyeon Jo, Soyoung Park, Tae-Gyun Woo, Bae-Hoon Kim, Goo Taeg Oh, Bum-Joon Park
Publikováno v:
Cells, Vol 12, Iss 9, p 1232 (2023)
Hutchinson–Gilford Progeria Syndrome (HGPS) is an ultra-rare human premature aging disorder that precipitates death because of cardiac disease. Almost all cases of HGPS are caused by aberrant splicing of the LMNA gene that results in the production
Externí odkaz:
https://doaj.org/article/16b4345b9ddd4d9fbee0fbc11e61f17a
Autor:
So‑mi Kang, Min‑Ho Yoon, Su‑Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae‑Gyun Woo, Jung‑Hyun Cho, Jaecheol Lee, Nam‑Chul Ha, Bum‑Joon Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/428ebffdc66f4231b713e0d9a95b58d2
Autor:
So-mi Kang, Min-Ho Yoon, Jinsook Ahn, Ji-Eun Kim, So Young Kim, Seock Yong Kang, Jeongmin Joo, Soyoung Park, Jung-Hyun Cho, Tae-Gyun Woo, Ah-Young Oh, Kyu Jin Chung, So Yon An, Tae Sung Hwang, Soo Yong Lee, Jeong-Su Kim, Nam-Chul Ha, Gyu-Yong Song, Bum-Joon Park
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and
Externí odkaz:
https://doaj.org/article/f096a2f1eb914af38e3c04e0baf1efeb
Publikováno v:
Journal of Functional Foods, Vol 87, Iss , Pp 104843- (2021)
Externí odkaz:
https://doaj.org/article/f29264788cdf42ecab493b91b6392ce3
Autor:
Jinsook Ahn, Inseong Jo, So-mi Kang, Seokho Hong, Suhyeon Kim, Soyeon Jeong, Yong-Hak Kim, Bum-Joon Park, Nam-Chul Ha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemic
Externí odkaz:
https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c7