Zobrazeno 1 - 10
of 147
pro vyhledávání: '"So-Yon Lim"'
Autor:
James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is s
Externí odkaz:
https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009281 (2021)
Intrinsic resistance is a crucial line of defense against virus infections, and members of the Tripartite Ring Interaction Motif (TRIM) family of proteins are major players in this system, such as cytoplasmic TRIM5α or nuclear promyelocytic leukemia
Externí odkaz:
https://doaj.org/article/60218ac4f83d49968f176ef3c3ddbd6c
Autor:
Hongzhao Li, Yan Hai, So-Yon Lim, Nikki Toledo, Jose Crecente-Campo, Dane Schalk, Lin Li, Robert W Omange, Tamara G Dacoba, Lewis R Liu, Mohammad Abul Kashem, Yanmin Wan, Binhua Liang, Qingsheng Li, Eva Rakasz, Nancy Schultz-Darken, Maria J Alonso, Francis A Plummer, James B Whitney, Ma Luo
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202997 (2018)
HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4+ T cell activation could be effective. Learning from natural immunity observed in a group of
Externí odkaz:
https://doaj.org/article/5a0bd10aa4a94417af351aa2f560411c
Autor:
R Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D Sloan, Dan Karel, Hing C Wong, Emily K Jeng, Allison S Thomas, James B Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A Ostrowski, Darrell J Irvine, Bruce D Walker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005545 (2016)
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently c
Externí odkaz:
https://doaj.org/article/8d9eef0385234f16ae9fba721f3491fb
Autor:
Lawrence J Tartaglia, Hui-Wen Chang, Benjamin C Lee, Peter Abbink, David Ng'ang'a, Michael Boyd, Christy L Lavine, So-Yon Lim, Srisowmya Sanisetty, James B Whitney, Michael S Seaman, Morgane Rolland, Sodsai Tovanabutra, Jintanat Ananworanich, Merlin L Robb, Jerome H Kim, Nelson L Michael, Dan H Barouch
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005431 (2016)
Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack of a SHIV challenge stock exp
Externí odkaz:
https://doaj.org/article/0899c712d65040b8ad5ae326e29e434a
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/cf96ef53fb094e97a5d93160510e619a
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002436 (2011)
While the contribution of CD8⁺ cytotoxic T lymphocytes to early containment of HIV-1 spread is well established, a role for NK cells in controlling HIV-1 replication during primary infection has been uncertain. The highly polymorphic family of KIR
Externí odkaz:
https://doaj.org/article/0ad80daa820e4cb8a48a92f6e2739cd4
Autor:
So-Yon Lim, Tiffany Chan, Rebecca S Gelman, James B Whitney, Kara L O'Brien, Dan H Barouch, David B Goldstein, Barton F Haynes, Norman L Letvin
Publikováno v:
PLoS Genetics, Vol 6, Iss 6, p e1000997 (2010)
CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 acquisition and with both vir
Externí odkaz:
https://doaj.org/article/60c4dc61353044759a39108016bac706
Autor:
So-Yon Lim, Thomas Rogers, Tiffany Chan, James B Whitney, Jonghwa Kim, Joseph Sodroski, Norman L Letvin
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000738 (2010)
The cytoplasmic TRIM5alpha proteins of certain mammalian lineages efficiently recognize the incoming capsids of particular retroviruses and potently restrict infection in a species-specific manner. Successful retroviruses have evolved capsids that ar
Externí odkaz:
https://doaj.org/article/4931bdceb9fb4ac18116a7437864b337
Autor:
So-Yon Lim1, Jina Lee1, Osuna, Christa E.1, Vikhe, Pratik1, Schalk, Dane R.2, Chen, Elsa1, Fray, Emily3, Kumar, Mithra3, Schultz-Darken, Nancy2, Rakasz, Eva2, Capuano, Saverio2, Ladd, Ruby A2, Gil, Hwi Min2, Evans, David T.2, Jeng, Emily K.4, Seaman, Michael1, Martin, Malcolm5, Van Dorp, Christiaan6, Perelson, Alan S.6,7, Wong, Hing C.4,8
Publikováno v:
Science. 3/8/2024, Vol. 383 Issue 6687, p1104-1111. 8p. 4 Diagrams.