Systemic analysis of lipid metabolism from individuals to multi-organism systems.

Autor: Furse S; Royal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK. s.furse@kew.org.; Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, UK., Martel C; Royal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK. s.furse@kew.org., Willer DF; Department of Zoology, The David Attenborough Centre, University of Cambridge, Corn Exchange St., Cambridge, CB2 3QZ, UK., Stabler D; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK.; School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK., Fernandez-Twinn DS; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Keith Day Road, Cambridge, CB2 0QQ, UK., Scott J; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK., Patterson-Cross R; Bioinformatics Core, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, UK., Watkins AJ; Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK., Virtue S; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Keith Day Road, Cambridge, CB2 0QQ, UK., Prescott TAK; Royal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK. s.furse@kew.org., Baker E; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK., Chennells J; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK., Vidal-Puig A; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Keith Day Road, Cambridge, CB2 0QQ, UK., Ozanne SE; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Keith Day Road, Cambridge, CB2 0QQ, UK., Kite GC; Royal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK. s.furse@kew.org., Vítová M; Institute of Botany, Czech Academy of Sciences, Department of Phycology, Dukelská 135, 379 01 Třeboň, Czech Republic., Chiarugi D; Bioinformatics Core, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, UK.; Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Sachsen, Germany., Moncur J; SpectralWorks Limited, The Heath Business and Technical Park, Runcorn, Cheshire, WA7 4EB, UK., Koulman A; Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Keith Day Road, Cambridge, CB2 0QQ, UK.; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Keith Day Road, Cambridge, CB2 0QQ, UK., Wright GA; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK., Snowden SG; Department of Biological Sciences, Royal Holloway College, University of London, Egham, Surrey, TW20 0EX, UK., Stevenson PC; Royal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK. s.furse@kew.org.; Natural Resources Institute, University of Greenwich, Chatham, Kent, ME4 4TB, UK.

Publikováno v: Molecular omics [Mol Omics] 2024 Oct 28; Vol. 20 (9), pp. 570-583. Date of Electronic Publication: 2024 Oct 28.

Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau ( MAPT ) Mutant Dopamine Neurons.

Autor: Bradford X; Department of Biological Sciences, Royal Holloway University of London, London TW20 0EX, UK., Fernandes HJR; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK., Snowden SG; Department of Biological Sciences, Royal Holloway University of London, London TW20 0EX, UK.; Core Metabolomics and Lipidomics Laboratory, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Apr 24; Vol. 13 (5). Date of Electronic Publication: 2024 Apr 24.

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT.

Autor: Fernandes HJR; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK., Kent JP; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK.; Core Metabolomics and Lipidomics Laboratory, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Bruntraeger M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Bassett AR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Koulman A; Core Metabolomics and Lipidomics Laboratory, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Metzakopian E; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK., Snowden SG; Department of Biological Sciences, Royal Holloway University of London, Egham, London TW20 0EX, UK.

Publikováno v: Metabolites [Metabolites] 2023 Jan 09; Vol. 13 (1). Date of Electronic Publication: 2023 Jan 09.

Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms.

Autor: Hudert CA; Department of Pediatric Gastroenterology, Nephrology and Metabolic DiseasesCharité Universitätsmedizin BerlinBerlinGermany., Adams LA; Medical SchoolUniversity of Western AustraliaPerthAustralia.; Department of HepatologySir Charles Gairdner HospitalPerthAustralia., Alisi A; Research Unit of Molecular Genetics of Complex PhenotypesBambino Gesù Children's Hospital-Istituto di Ricovero e Cura a Carattere ScientificoRomeItaly., Anstee QM; 5994Translational and Clinical Research InstituteFaculty of Medical SciencesNewcastle UniversityNewcastle upon TyneUK.; Newcastle National Institute for Health Research Biomedical Research CentreNewcastle upon Tyne Hospitals National Health Service Foundation TrustNewcastle upon TyneUK., Crudele A; Research Unit of Molecular Genetics of Complex PhenotypesBambino Gesù Children's Hospital-Istituto di Ricovero e Cura a Carattere ScientificoRomeItaly., Draijer LG; Department of Pediatric Gastroenterology and NutritionAmsterdam University Medical CenterEmma Children's HospitalUniversity of AmsterdamAmsterdamthe Netherlands., Furse S; Core Metabolomics and Lipidomics LaboratoryWellcome Trust-Medical Research Council Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK., Hengstler JG; Systems ToxicologyLeibniz Research Center for Working Environment and Human Factors at the Technical University DortmundDortmundGermany., Jenkins B; Core Metabolomics and Lipidomics LaboratoryWellcome Trust-Medical Research Council Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK., Karnebeek K; Center for Overweight Adolescent and Children's Health CareDepartment of PediatricsMaastricht University Medical CenterMaastrichtthe Netherlands., Kelly DA; Liver UnitBirmingham Womens and Children's Hospital TrustBirminghamUK., Koot BG; Department of Pediatric Gastroenterology and NutritionAmsterdam University Medical CenterEmma Children's HospitalUniversity of AmsterdamAmsterdamthe Netherlands., Koulman A; Core Metabolomics and Lipidomics LaboratoryWellcome Trust-Medical Research Council Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK., Meierhofer D; Max Planck Institute for Molecular GeneticsMass Spectrometry FacilityBerlinGermany., Melton PE; School of Global Population HealthFaculty of Health and Medical SciencesUniversity of Western AustraliaPerthAustralia.; School of Pharmacy and Biomedical SciencesFaculty of Health SciencesCurtin UniversityPerthAustralia.; Menzies Institute for Medical ResearchCollege of Health and MedicineUniversity of TasmaniaHobartAustralia., Mori TA; Medical SchoolUniversity of Western AustraliaPerthAustralia., Snowden SG; Core Metabolomics and Lipidomics LaboratoryWellcome Trust-Medical Research Council Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK., van Mourik I; Liver UnitBirmingham Womens and Children's Hospital TrustBirminghamUK., Vreugdenhil A; Center for Overweight Adolescent and Children's Health CareDepartment of PediatricsMaastricht University Medical CenterMaastrichtthe Netherlands., Wiegand S; Center for Chronically Sick ChildrenCharité Universitätsmedizin BerlinBerlinGermany., Mann JP; 2152Institute of Metabolic ScienceUniversity of CambridgeCambridgeUK.

Publikováno v: Hepatology communications [Hepatol Commun] 2022 Aug; Vol. 6 (8), pp. 1934-1948. Date of Electronic Publication: 2022 Apr 11.

Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study.

Autor: Mann JP; Institute of Metabolic Science., Jenkins B; Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC institute of Metabolic Science, University of Cambridge, Cambridge., Furse S; Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC institute of Metabolic Science, University of Cambridge, Cambridge., Snowden SG; Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC institute of Metabolic Science, University of Cambridge, Cambridge.; Department of Biological Sciences, Royal Holloway University of London, Egham, UK., Alisi A; Research Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Draijer LG; Department of Paediatric Gastroenterology and Nutrition, Amsterdam University Medical Centers, Emma Children's Hospital, Amsterdam, The Netherlands., Karnebeek K; Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Pediatrics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Kelly DA; Liver Unit, Birmingham Women's & Children's Hospital, and University of Birmingham, Birmingham, UK., Koot BG; Department of Paediatric Gastroenterology and Nutrition, Amsterdam University Medical Centers, Emma Children's Hospital, Amsterdam, The Netherlands., Mosca A; Hepatology Gastroenterology and Nutrition, Bambino Gesu Children's Hospital, Rome, Italy., Salvestrini C; Department of Paediatric Gastroenterology and Nutrition, Addenbrooke's Hospital., van Mourik I; Liver Unit, Birmingham Women's & Children's Hospital, and University of Birmingham, Birmingham, UK., Vreugdenhil A; Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Pediatrics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Zilbauer M; Department of Paediatric Gastroenterology and Nutrition, Addenbrooke's Hospital.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Koulman A; Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC institute of Metabolic Science, University of Cambridge, Cambridge.

Publikováno v: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2022 Jun 01; Vol. 74 (6), pp. 734-741. Date of Electronic Publication: 2022 Feb 19.