Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Snigdha Samarpita"'
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Background Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had poten
Externí odkaz:
https://doaj.org/article/4649908794d34f898ea939252ccabf8c
Publikováno v:
Immunological Investigations. 51:1582-1597
Fibroblast-like synoviocytes (FLS) are the critical effector cells primarily involved in rheumatoid arthritis (RA) disease pathogenesis. Interleukin (IL)-6, a proinflammatory cytokine most abundantly expressed in the rheumatoid synovium, promotes Jan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543f53ddf9559eeb162233b67a81294b
https://doi.org/10.1080/08820139.2021.1994589
https://doi.org/10.1080/08820139.2021.1994589
Autor:
Snigdha Samarpita, Xiaogang Li
Publikováno v:
International Journal of Molecular Sciences. 24:7647
In recent years, the launch of clinical-grade exosomes is rising expeditiously, as they represent a new powerful approach for the delivery of advanced therapies and for diagnostic purposes for various diseases. Exosomes are membrane-bound extracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb00f3ba9cbd8ba919a0a9b4fbea0cb6
https://doi.org/10.3390/ijms24087647
https://doi.org/10.3390/ijms24087647
Autor:
Snigdha Samarpita, Mahaboobkhan Rasool
Publikováno v:
Cytokine. 163:156136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3899c85ccfc7ecfa61574ad644ba7b6
https://doi.org/10.1016/j.cyto.2023.156136
https://doi.org/10.1016/j.cyto.2023.156136
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had potential as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c86c85c8743fdc3e005b1db5298149
https://doaj.org/article/4649908794d34f898ea939252ccabf8c
https://doaj.org/article/4649908794d34f898ea939252ccabf8c
Autor:
Seongin Jo, Snigdha Samarpita, Ji Su Lee, Yong Joon Lee, Joe Eun Son, Minju Jeong, Jae Hwan Kim, Seungpyo Hong, Seung-Ah Yoo, Wan-Uk Kim, Mahaboobkhan Rasool, Sanguine Byun
Publikováno v:
Pharmacological research. 178
Rheumatoid arthritis (RA) is a chronic immune-mediated disorder, mainly characterized by synovial inflammation and joint damage. If insufficiently treated, RA can lead to irreversible joint destruction and decreased life expectancy. While better unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b6b3f0949f9425b751e0b9ff2bf5fa
https://pubmed.ncbi.nlm.nih.gov/35283302
https://pubmed.ncbi.nlm.nih.gov/35283302
Autor:
B, Thirupataiah, Guntipally, Mounika, Gangireddy Sujeevan, Reddy, Jetta Sandeep, Kumar, Kazi Amirul, Hossain, Raghavender, Medishetti, Snigdha, Samarpita, Mahaboobkhan, Rasool, Jayesh, Mudgal, Jessy E, Mathew, Gautham G, Shenoy, C Mallikarjuna, Rao, Kiranam, Chatti, Kishore V L, Parsa, Manojit, Pal
Publikováno v:
European journal of medicinal chemistry. 221
While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e763f432a55d48daf040d57ef951bd
https://pubmed.ncbi.nlm.nih.gov/33992926
https://pubmed.ncbi.nlm.nih.gov/33992926
Autor:
B. Thirupataiah, Harshavardhan Bhuktar, Guntipally Mounika, Gangireddy Sujeevan Reddy, Jetta Sandeep Kumar, Sharda Shukla, Kazi Amirul Hossain, Raghavender Medishetti, Snigdha Samarpita, Mahaboobkhan Rasool, P.C. Jagadish, Gautham G. Shenoy, Kishore V.L. Parsa, Manojit Pal
Publikováno v:
Bioorganic Chemistry. 121:105667
In search of potent and new anti-inflammatory agents, we explored a new class of isocoumarin derivatives possessing the 3-oxoalkyl moiety at C-4 position. These compounds were synthesized via the FeCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166deade5a5ccc889bcae0d4b03426d3
https://doi.org/10.1016/j.bioorg.2022.105667
https://doi.org/10.1016/j.bioorg.2022.105667
Autor:
Snigdha Samarpita, Mahaboobkhan Rasool
Publikováno v:
International Immunopharmacology. 101:108359
Disturbed Th17/Treg balance is a critical pathological event in the disease progression of rheumatoid arthritis (RA). Recently, emerging studies have demonstrated that CD4 + T helper follicular (Tfh) cells exacerbates the pathogenic manifestations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686f1e4e727610ab95706e0a9aa37d96
https://doi.org/10.1016/j.intimp.2021.108359
https://doi.org/10.1016/j.intimp.2021.108359
Autor:
Gautham G. Shenoy, Kazi Amirul Hossain, C. Mallikarjuna Rao, Gangireddy Sujeevan Reddy, Raghavender Medishetti, Mahaboobkhan Rasool, Kishore V. L. Parsa, Manojit Pal, Guntipally Mounika, Jetta Sandeep Kumar, Jayesh Mudgal, Kiranam Chatti, B. Thirupataiah, Snigdha Samarpita, Jessy Elizabeth Mathew
Publikováno v:
European Journal of Medicinal Chemistry. 221:113514
While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6eb1ed69873e7de4a41198910caf90b
https://doi.org/10.1016/j.ejmech.2021.113514
https://doi.org/10.1016/j.ejmech.2021.113514