Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity.

Autor: Narmada BC; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672; Experimental Drug Development Centre, A∗STAR, 10 Biopolis Way, Chromos, Singapore 138670, Singapore., Khakpoor A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Shirgaonkar N; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672., Narayanan S; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Aw PPK; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672., Singh M; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Ong KH; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Owino CO; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ng JWT; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yew HC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Binte Mohamed Nasir NS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Au VB; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Sng R; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore., Khine HHTW; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., di Tocco FC; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France., Masayuki O; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Naikar S; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Ng HX; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chia SL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Seah CXY; Department of Medicine, National University Hospital, Singapore., Alnawaz MH; Department of Medicine, National University Hospital, Singapore., Wai CLY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tay AYL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Mangat KS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chew V; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre, Singapore 169856, Singapore., Yu W; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Bioinformatics Institute, A∗STAR, 30 Biopolis Street, Matrix, Singapore 138671, Singapore., Connolly JE; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute of Biomedical Studies, Baylor University, Waco, TX, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Periyasamy G; Experimental Drug Development Centre, A∗STAR, 10 Biopolis Way, Chromos, Singapore 138670, Singapore., Plissonnier ML; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France., Levrero M; Cancer Research Center of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Lyon, France; Department of Hepatology, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France; University of Lyon Claude Bernard 1 (UCLB1), Lyon, France; Department of Medicine SCIAC and the Italian Institute of Technology (IIT) Center for Life Nanosciences (CLNS), University of Rome La Sapienza, Rome, Italy., Lim SG; Institute of Molecular and Cell Biology, A∗STAR, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore; Department of Medicine, National University Hospital, Singapore; Division of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore. Electronic address: mdclimsg@nus.edu.sg., DasGupta R; Laboratory of Precision Medicine and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A∗STAR), 60 Biopolis St., #02-01 Genome, Singapore 138672. Electronic address: dasguptar@gis.a-star.edu.sg.

Publikováno v: Journal of hepatology [J Hepatol] 2024 Jul; Vol. 81 (1), pp. 42-61. Date of Electronic Publication: 2024 Feb 28.

Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit.

Autor: Nickles E; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, Singapore, Singapore.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Dharmadhikari B; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, Singapore, Singapore.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yating L; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, Singapore, Singapore.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Walsh RJ; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Koh LP; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Poon M; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Tan LK; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Wang LZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ang Y; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Asokumaran Y; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Chong WQ; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Huang Y; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Loh KS; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Tay J, Soo R; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore., Koh M; Health Sciences Authority, Singapore, Singapore., Ho LP; Health Sciences Authority, Singapore, Singapore., Chan M; Health Sciences Authority, Singapore, Singapore., Niam M; Health Sciences Authority, Singapore, Singapore., Soh M; Health Sciences Authority, Singapore, Singapore., Luah YH; Health Sciences Authority, Singapore, Singapore., Lim CM; Department of Otolaryngology - Head and Neck Surgery, Singapore General Hospital, Singapore, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Au VB; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Talib NBSN; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Sng R; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Connolly JE; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Goh BC; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore. phcgbc@nus.edu.sg., Schwarz H; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. phssh@nus.edu.sg.; Life Sciences Institute, Immunology Programme, National University of Singapore, Singapore, Singapore. phssh@nus.edu.sg.; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. phssh@nus.edu.sg.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2022 Jun; Vol. 71 (6), pp. 1531-1543. Date of Electronic Publication: 2021 Oct 18.

Community-based aftercare following an emergency department presentation for attempted suicide or high risk for suicide: study protocol for a non-randomised controlled trial.

Autor: Bliokas VV; University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia. vida@uow.edu.au.; Illawarra Health and Medical Research Institute, Northfields Avenue, Wollongong, NSW, 2522, Australia. vida@uow.edu.au., Hains AR; Illawarra Health and Medical Research Institute, Northfields Avenue, Wollongong, NSW, 2522, Australia.; Illawarra Shoalhaven Suicide Prevention Collaborative, The Central, Innovation Campus, Wollongong, NSW, 2500, Australia.; Coordinare, Primary Health Network South Eastern NSW, The Central, Innovation Campus, Squires Way, Wollongong, NSW, 2500, Australia., Allan JA; University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia., Lago L; Centre for Health Research Illawarra Shoalhaven Population, University of Wollongong, Building 234, Innovation Campus, Wollongong, NSW, 2500, Australia., Sng R; Grand Pacific Health, 336 Keira Street, Wollongong, NSW, 2500, Australia.

Publikováno v: BMC public health [BMC Public Health] 2019 Oct 26; Vol. 19 (1), pp. 1380. Date of Electronic Publication: 2019 Oct 26.

Suicidal behaviors and associated factors among patients attending an emergency department: a facility-based cross-sectional study.

Autor: Wordefo, Dureti Kassim¹ (AUTHOR), Kassim, Faiz Mohammed¹ (AUTHOR) faiz.mohammed@sphmmc.edu.et, Birhanu, Elizabeth¹ (AUTHOR), Mamo, Girma¹ (AUTHOR)

Publikováno v: BMC Psychiatry. 6/25/2023, Vol. 23 Issue 1, p1-11. 11p. 3 Charts, 2 Graphs.

Syndemic relationship of depressive symptoms, substance use, and suicidality in transgender youth: a cross-sectional study using the U.S. youth risk behavior surveillance system.

Autor: Lett, Elle^1,2 (AUTHOR) ellel@upenn.edu, Abrams, Matthew P.^3,4 (AUTHOR), Moberg, Emery⁵ (AUTHOR), Benson, G. Perusi⁶ (AUTHOR), Perlson, Jacob E.⁷ (AUTHOR)

Publikováno v: Social Psychiatry & Psychiatric Epidemiology. Nov2022, Vol. 57 Issue 11, p2293-2304. 12p.