Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Snezana Milutinovic"'
Autor:
Haineng Xu, Sarah B. Gitto, Gwo-Yaw Ho, Sergey Medvedev, Kristy Shield-Artin, Hyoung Kim, Sally Beard, Yasuto Kinose, Xiaolei Wang, Holly E. Barker, Gayanie Ratnayake, Wei-Ting Hwang, Ryan J. Hansen, Bryan Strouse, Snezana Milutinovic, Christian Hassig, Matthew J. Wakefield, Cassandra J. Vandenberg, Clare L. Scott, Fiona Simpkins
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109978- (2024)
Summary: High-grade serous ovarian cancers (HGSOCs) with homologous recombination deficiency (HRD) are initially responsive to poly (ADP-ribose) polymerase inhibitors (PARPi), but resistance ultimately emerges. HGSOC with CCNE1 amplification (CCNE1am
Externí odkaz:
https://doaj.org/article/1ed5cdda17844d2e8fc282a3b801056b
Autor:
Snezana Milutinovic, Susanne Heynen-Genel, Elizabeth Chao, Antimone Dewing, Ricardo Solano, Loribelle Milan, Nikki Barron, Min He, Paul W Diaz, Shu-ichi Matsuzawa, John C Reed, Christian A Hassig
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152692 (2016)
Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of
Externí odkaz:
https://doaj.org/article/a364f22c4b134ec388b740ffc3d32178
Autor:
Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosford
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161952 (2016)
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously
Externí odkaz:
https://doaj.org/article/586e88ab700843089041a6fb4004bf01
Autor:
Feng Tian, Yi Gu, Sulan Yao, Shiao-Yan Fang, Wayne Yu, Ianina Lopez, Kristine Storey, Robin Marsden, Jessica Kirtley, Sandra Lyn Biroc, Wisam Barkho, Snezana Milutinovic, Amha Gebre Hewet, Nick A. Knudsen, Sukumar Sakamuri, Lillian Skidmore
Amino acid sequence of the antibody used in ARX788. The complementarity determining regions (CDRs) are underlined, and the pAF is depicted as a "U".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba9be2ac4c8985e17126246813d6898
https://doi.org/10.1158/1535-7163.22521019
https://doi.org/10.1158/1535-7163.22521019
Autor:
Feng Tian, Yi Gu, Sulan Yao, Shiao-Yan Fang, Wayne Yu, Ianina Lopez, Kristine Storey, Robin Marsden, Jessica Kirtley, Sandra Lyn Biroc, Wisam Barkho, Snezana Milutinovic, Amha Gebre Hewet, Nick A. Knudsen, Sukumar Sakamuri, Lillian Skidmore
First-generation antibody–drug conjugates (ADC) are heterogeneous mixtures that have shown clinical benefit, but generally exhibited safety issues and a narrow therapeutic window due, in part, to off-target toxicity caused by ADC instability. ARX78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde81fcd8199a2863a821a2439e8526
https://doi.org/10.1158/1535-7163.c.6542869
https://doi.org/10.1158/1535-7163.c.6542869
Autor:
Sudhir Chowdhry, Snezana Milutinovic, Edison Tse, Salvador Garcia, Dean Perusse, Melissa Ritland, Juyeon Ko, Deepti Wilkinson, Kristen Turner, Auzon Steffy, Joshua Plum, Ben Norman, AnnMarie Pferdekamper, Todd Meyer, Debbie Liao, Rachelle Elsdon, Joshua Lange, Anthony Pinkerton, Ryan Hansen, Christian Hassig, Shailaja Kasibhatla
Publikováno v:
Cancer Research. 83:1626-1626
Patients whose tumors harbor oncogene amplification on extrachromosomal DNA (ecDNA) fail to respond to targeted or immune therapy and have poor prognosis. ecDNA are cancer-specific circular fragments of genomic DNA engendered with unique properties,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad18443f5ae9134461409891ffb6476
https://doi.org/10.1158/1538-7445.am2023-1626
https://doi.org/10.1158/1538-7445.am2023-1626
Autor:
Triparna Sen, Carminia M. Della Corte, Snezana Milutinovic, Robert J. Cardnell, Lixia Diao, Kavya Ramkumar, Carl M. Gay, C. Allison Stewart, Youhong Fan, Li Shen, Ryan J. Hansen, Bryan Strouse, Michael P. Hedrick, Christian A. Hassig, John V. Heymach, Jing Wang, Lauren A. Byers
Publikováno v:
J Thorac Oncol
Introduction Despite the enthusiasm surrounding cancer immunotherapy, most SCLC patients show very modest response to immune checkpoint inhibitor monotherapy treatment. Therefore, there is growing interest in combining immune checkpoint blockade with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b45e5e2d7f6a9fdb4cc5387c65b7be1
https://doi.org/10.1016/j.jtho.2019.08.009
https://doi.org/10.1016/j.jtho.2019.08.009
Autor:
Sudhir Chowdhry, Salvador Garcia, Nam-Phuong Nguyen, Anthony Celeste, Edison Tse, Snezana Milutinovic, Deepti Wilkinson, Christian Hassig, Shailaja Kasibhatla
Publikováno v:
Cancer Research. 82:1520-1520
Replication stress (RS) is a primary source of genomic instability, tumorigenesis, and cancer progression. RS is defined as an uncoupling of the replicative helicase and DNA polymerase, resulting in long stretches of fragile single stranded DNA (ssDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f20386fa22042b6b8f7f15277bd58f2
https://doi.org/10.1158/1538-7445.am2022-1520
https://doi.org/10.1158/1538-7445.am2022-1520
Autor:
Snezana Milutinovic, Sandra Biroc, Wisam Barkho, Robin Marsden, Lillian Skidmore, Wayne Yu, Amha Hewet, Feng Tian, Kristine Storey, Jessica Kirtley, Nick Knudsen, Sukumar Sakamuri, Sulan Yao, Yi Gu, Ianina Lopez, Shiao-Yan Fang
Publikováno v:
Molecular cancer therapeutics. 19(9)
First-generation antibody–drug conjugates (ADC) are heterogeneous mixtures that have shown clinical benefit, but generally exhibited safety issues and a narrow therapeutic window due, in part, to off-target toxicity caused by ADC instability. ARX78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2d27d3b9ff3aaf53a7164cc88eb57f
https://pubmed.ncbi.nlm.nih.gov/32669315
https://pubmed.ncbi.nlm.nih.gov/32669315
Autor:
John C. Reed, Snezana Milutinovic, Teruki Yanagi, Arun K. Kashyap, Sihong Zhou, Shu-ichi Matsuzawa, Ryann O'Neil, Michael Horowitz, Ramesh R. Bhatt, Carina Wimer, Charles H. Hannum, Aaron L. Kurtzman, Lawrence Horowitz, Alexsandr Faynboym, Paul Diaz, Li Xu
Publikováno v:
Molecular Cancer Therapeutics. 15:114-124
Death receptors of the TNF family are found on the surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors 4 and 5 (DR4 and D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a55be4349e5676bc07de4a847f827fc
https://doi.org/10.1158/1535-7163.mct-15-0400
https://doi.org/10.1158/1535-7163.mct-15-0400