Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice.

Autor: Cayatte, Corinne¹ cayattec@medimmune.com, Snell Bennett, Angie¹, Rajani, Gaurav Manohar¹, Hostetler, Leigh², Maynard, Sean K.¹, Lazzaro, Michelle¹, Mctamney, Patrick¹, Ren, Kuishu¹, O'day, Terrence³, Mccarthy, Michael P.¹, Schneider-Ohrum, Kirsten¹

Publikováno v: PLoS ONE. 11/28/2017, Vol. 12 Issue 11, p1-18. 18p.

CD4 ⁺ T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model.

Autor: Schneider-Ohrum K; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA., Snell Bennett A; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA., Rajani GM; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA., Hostetler L; Laboratory Animal Resources, MedImmune, Gaithersburg, Maryland, USA., Maynard SK; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA., Lazzaro M; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA., Cheng LI; Pathology Department, MedImmune, Gaithersburg, Maryland, USA., O'Day T; Statistical Sciences, MedImmune, Gaithersburg, Maryland, USA., Cayatte C; Department of Infectious Disease/Vaccines, MedImmune, Gaithersburg, Maryland, USA cayattec@medimmune.com.

Publikováno v: Journal of virology [J Virol] 2019 Jul 17; Vol. 93 (15). Date of Electronic Publication: 2019 Jul 17 (Print Publication: 2019).