Výsledky vyhledávání - "Snelgrove RJ"

The development of novel LTA4H modulators to selectively target LTB4 generation

Autor: Low, CM, Akthar, S, Patel, D, Loeser, S, Wong, C, Jackson, P, Blalock, JE, Hare, S, Lloyd, C, Snelgrove, RJ

Publikováno v: Scientific Reports

The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad45bda305652af62ca69f314988a55a

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Neutrophils deliver TRAIL mediated protection from acute cytomegalovirus infection

Autor: Stacey, MA, Marsden, M, Dolton, G, Stack, G, Jones, E, Klenerman, P, Gallimore, AM, Taylor, PR, Jones, SA, Snelgrove, RJ, Wilkinson, GW, Humphreys, IR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2ffe40d218d7f1ed0a46ef067e41878f
https://ora.ox.ac.uk/objects/uuid:b8b7cdf9-cfb1-4779-888e-3f0aed84d36c

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CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue

Autor: Stack, G, Jones, E, Marsden, M, Stacey, MA, Snelgrove, RJ, Lacaze, P, Jacques, LC, Cuff, SM, Stanton, RJ, Gallimore, AM, Hussell, T, Wilkinson, GWG, Ghazal, P, Taylor, PR, Humphreys, IR

Publikováno v: Stack, G, Jones, E, Marsden, M, Stacey, M A, Snelgrove, R J, Lacaze, P, Jacques, L C, Cuff, S M, Stanton, R J, Gallimore, A M, Hussell, T, Wilkinson, G W G, Ghazal, P, Taylor, P R & Humphreys, I R 2015, ' CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue ', PLoS Pathogens, vol. 11, no. 2, e1004641 . https://doi.org/10.1371/journal.ppat.1004641
PLoS Pathogens, Vol 11, Iss 2, p e1004641 (2015)
PLoS Pathogens
PLOS Pathogens

CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa80b7ef323bae5c4cece0ab7c052a84
https://www.pure.ed.ac.uk/ws/files/19031455/journal.ppat.1004641.pdf

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Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

Autor: Eltom, S, Dale, N, Raemdonck, KRG, Stevenson, CS, Snelgrove, RJ, Sacitharan, PK, Recchi, C, Wavre-Shapton, S, McAuley, DF, O'Kane, C, Belvisi, MG, Birrell, MA, Chan, RWY

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e101087 (2014)
PLoS ONE
Eltom, S, Dale, N, Raemdonck, K R G, Stevenson, C S, Snelgrove, R J, Sacitharan, P K, Recchi, C, Wavre-Shapton, S, McAuley, D F, O'Kane, C, Belvisi, M G & Birrell, M A 2014, ' Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD ', PloS one, vol. 9, no. 6, e101087 . https://doi.org/10.1371/journal.pone.0101087

Background Infection-related exacerbations of respiratory diseases are a major health concern; thus understanding the mechanisms driving them is of paramount importance. Despite distinct inflammatory profiles and pathological differences, asthma and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606d9782014ac3be301e3a59a6b0f31
http://europepmc.org/articles/PMC4074193?pdf=render

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Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

Autor: Snelgrove, RJ, Gregory, LG, Peiro, T, Akthar, S, Campbell, GA, Walker, SA, Lloyd, CM

Publikováno v: 592.e6

BackgroundThe fungal allergen Alternaria alternata is implicated in severe asthma and rapid onset life-threatening exacerbations of disease. However, the mechanisms that underlie this severe pathogenicity remain unclear.ObjectiveWe sought to investig

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