Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Snehlata Tripathi"'
Autor:
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Erin Purcell-Estabrook, Juili Dilip Shelke, Himali Shah, Anthony Lamattina, Qianli Pan, Brett Schrand, Frank Favaloro, Mugdha Bedekar, Arindom Chatterjee, Jigar Desai, Tomomi Kawamoto, Genliang Lu, Jake Metterville, Milinda Samaraweera, Priyanka Shiva Prakasha, Hailin Yang, Yuan Yin, Hui Yu, Paloma H Giangrande, Michael Byrne, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 51:4126-4147
Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52fce2dc6c2c20d3fb621264918bd6b
https://doi.org/10.1093/nar/gkad268
https://doi.org/10.1093/nar/gkad268
Autor:
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H. Apponi, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nature Biotechnology. 40:1093-1102
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to specific cellular RNAs have therapeutic potential, but translating them from cell culture into animal models has been challenging. Here we describe short, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e36a5ee2c78d18679d808cc838638dd
https://doi.org/10.1038/s41587-022-01225-1
https://doi.org/10.1038/s41587-022-01225-1
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Geeti Gangal, Sonke Svenson, Chester A. Metcalf, Pochi Shum, Snehlata Tripathi, Jungyeon Hwang, Stephanie Harlfinger, Beata Sweryda-Krawiec, Roy I. Case, Douglas Lazarus, Derek van der Poll, Sujan Kabir, Donna Brown, Ellen Rohde, Chi-Hse Teng, Roderic O. Cole, Scott Eliasof
Publikováno v:
Journal of Medicinal Chemistry. 62:9541-9559
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27195bb3a1196c25d218ec36152dd0c0
https://doi.org/10.1021/acs.jmedchem.9b00892
https://doi.org/10.1021/acs.jmedchem.9b00892
Autor:
Pei-Sze Ng, Patrick Lim Soo, Sonke Svenson, Snehlata Tripathi, Roy I. Case, Sujan Kabir, Douglas Lazarus, Pochi Shum, Roderick O. Cole, Derek van der Poll, Jungyeon Hwang, Scott Eliasof, Beata Sweryda-Krawiec, Christian G. Peters
Publikováno v:
Molecular Pharmaceutics. 13:737-747
Small interfering RNA (siRNA) therapeutics have potential advantages over traditional small molecule drugs such as high specificity and the ability to inhibit otherwise "undruggable" targets. However, siRNAs have short plasma half-lives in vivo, can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6dc7df9c818abf01ff6a91394598e0
https://doi.org/10.1021/acs.molpharmaceut.5b00608
https://doi.org/10.1021/acs.molpharmaceut.5b00608
Autor:
Roger Condom, Gregory Upert, Nadia Patino, Mohamed Mehiri, Audrey Di Giorgio, Snehlata Tripathi, Virendra N. Pandey
Publikováno v:
Oligonucleotides. 18:245-256
With the aim of developing a general and straightforward procedure for the intracellular delivery of naked peptide nucleic acids (PNAs), we designed an intracellularly biodegradable triphenylphosphonium (TPP) cation based transporter system. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d474610b5005f0af27e855af1d020165
https://doi.org/10.1089/oli.2008.0126
https://doi.org/10.1089/oli.2008.0126
Publikováno v:
Oligonucleotides. 18:9-20
Polyamide (peptide) nucleic acids conjugated with membrane-penetrating peptide are potential antisense therapeutic agents because of their unique chemical properties, high target specificity, and efficient cellular uptake. However, studies of their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053d42631aee0ad40008e619a32ba679
https://doi.org/10.1089/oli.2007.0088
https://doi.org/10.1089/oli.2007.0088
Autor:
Dylan Harris, Snehlata Tripathi, Sabyasachi Ganguly, Virendra N. Pandey, Binay Chaubey, Ralph A. Casale
Publikováno v:
Nucleic Acids Research
The transactivator responsive region (TAR) present in the 5'-NTR of the HIV-1 genome represents a potential target for antiretroviral intervention and a model system for the development of specific inhibitors of RNA-protein interaction. Earlier, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87acf4eb65aae6c83cae763c9cec12b8
https://doi.org/10.1093/nar/gki743
https://doi.org/10.1093/nar/gki743
Autor:
Virendra N. Pandey, Binay Chaubey, Snehlata Tripathi, Dylan Harris, Sabyasachi Ganguly, Ralph A. Casale
Publikováno v:
Virology. 331:418-428
We have earlier reported that anti-TAR PNA conjugated with the membrane-transducing peptide transportan inhibits transactivation of the HIV-1 LTR resulting in decreased production of HIV-1 virions by chronically infected H9 cells (N., Kaushik, A., Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70ef9c9868f9bafd8977a994a8c1002
https://doi.org/10.1016/j.virol.2004.10.032
https://doi.org/10.1016/j.virol.2004.10.032