Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Autor: Kristy Red-Horse, William R. Goodyer, Lei Tian, James B Hu, Michael Hesse, Haodi Wu, Paul J. M. Wijnker, Jan W. Buikema, Sean M. Wu, Daniel Lee, Yi Miao, K. Christopher Garcia, Joost P.G. Sluijter, Joy Y. Wu, David T. Paik, Aimee Beck, Larissa M. Dorsch, Srilatha Swami, Jolanda van der Velden, Pieter A. Doevendans, Benjamin Beyersdorf, Caroline Geisen, Guang Li, Sharon L. Paige, Alain van Mil, Renee G.C. Maas, Soah Lee, Nazan Puluca, Siyeon Rhee, Orlando Chirikian, Joseph C. Wu, Francisco X Galdos, Bernd K. Fleischmann, Stefan Jovinge, Maike Schuldt, Sneha Venkamatran, Vahid Serpooshan

Publikováno v: Cell Stem Cell
Buikema, J W, Lee, S, Goodyer, W R, Maas, R G, Chirikian, O, Li, G, Miao, Y, Paige, S L, Lee, D, Wu, H, Paik, D T, Rhee, S, Tian, L, Galdos, F X, Puluca, N, Beyersdorf, B, Hu, J, Beck, A, Venkamatran, S, Swami, S, Wijnker, P, Schuldt, M, Dorsch, L M, van Mil, A, Red-Horse, K, Wu, J Y, Geisen, C, Hesse, M, Serpooshan, V, Jovinge, S, Fleischmann, B K, Doevendans, P A, van der Velden, J, Garcia, K C, Wu, J C, Sluijter, J P G & Wu, S M 2020, ' Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes ', Cell Stem Cell, vol. 27, no. 1, pp. 50-63 . https://doi.org/10.1016/j.stem.2020.06.001
Cell Stem Cell, 27(1), 50-63. Cell Press

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (5-fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b34017e3e4efaa6fb5e71268924483c
https://doi.org/10.1016/j.stem.2020.06.001