A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans

Autor: Sneha L. Koneru, Fu Xiang Quah, Ritobrata Ghose, Mark Hintze, Nicola Gritti, Jeroen Sebastiaan van Zon, Michalis Barkoulas

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Developmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a popula

Externí odkaz: https://doaj.org/article/b3d14064a7df42bfb896368139637f03

Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

Autor: Mark Hintze, Michalis Barkoulas, Dimitris Katsanos, Sneha L. Koneru

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications

A fundamental question in medical genetics is how the genetic background modifies the phenotypic outcome of mutations. We address this question by focusing on the seam cells, which display stem cell properties in the epidermis of Caenorhabditis elega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caff0d28cc092c947c491c867b4c00d2
https://doaj.org/article/4e46d30d12474282beb7d61ec7f184b5

A cell fate switch in theC. elegansseam cell lineage occurs through modulation of the Wnt asymmetry pathway in response to temperature increase

Autor: Michalis Barkoulas, Sophie P. R. Gilbert, Mark Hintze, Sneha L. Koneru, Dimitris Katsanos

Populations often display consistent developmental phenotypes across individuals despite the inevitable biological stochasticity. Nevertheless, developmental robustness has limits and systems can fail upon change in the environment or the genetic bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6c2e162a7114ab38ac19edc3003607
https://doi.org/10.1101/849174

Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Autor: Ritobrata Ghose, Jeroen S. van Zon, Peter J. Appleford, Alison Woollard, Sneha L. Koneru, Dimitris Katsanos, Nicola Gritti, Lamia Mestek Boukhibar, Michalis Barkoulas, Richard J. Poole, Maria Doitsidou

Publikováno v: PLOS Biology
PLoS Biology, Vol 15, Iss 11, p e2002429 (2017)
PLoS Biology
Katsanos, D, Koneru, S L, Mestek Boukhibar, L, Gritti, N, Ghose, R, Appleford, P J, Doitsidou, M, Woollard, A, van Zon, J S, Poole, R J & Barkoulas, M 2017, ' Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number ', PLoS Biology, vol. 15, no. 11, pp. e2002429 . https://doi.org/10.1371/journal.pbio.2002429

Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf74ca806e2d52f91f00232a26772f6f

Corrigendum

Autor: Sneha L. Koneru, Heilly Salinas, Gilberto E. Flores, Ray L. Hong

Publikováno v: Molecular Ecology. 25:6267-6267

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b619ecff9b66395d0d6317e72d610e4a
https://doi.org/10.1111/mec.13924