Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sneha Grandhi"'
Autor:
Ruipeng Wei,, Ying Ni,, Peter Bazeley,, Sneha Grandhi,, Janet Wang,, Samuel T. Li,, Stanley L. Hazen,, W. H. Wilson Tang,, Thomas LaFramboise,
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background We sought to determine whether mitochondrial DNA (mtDNA) content can be used as markers for 12 key phenotypes among cardiovascular disease patients, and whether these markers are valid across patients with diverse ancestries. Methods and R
Externí odkaz:
https://doaj.org/article/3667804c5caf4c868acead37ec805690
Publikováno v:
BMC Bioinformatics, Vol 18, Iss S12, Pp 29-36 (2017)
Abstract Background Chromosomal deletions represent an important class of human genetic variation. Various methods have been developed to mine “next-generation” sequencing (NGS) data to detect deletions and quantify their clonal abundances. These
Externí odkaz:
https://doaj.org/article/2f221438c491488aba92399be221c254
Autor:
Meetha P Gould, Colleen M Bosworth, Sarah McMahon, Sneha Grandhi, Brian T Grimberg, Thomas LaFramboise
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156884 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0139253.].
Externí odkaz:
https://doaj.org/article/1a3ee58b528f43a98f125a15eaca07a1
Autor:
Meetha P Gould, Colleen M Bosworth, Sarah McMahon, Sneha Grandhi, Brian T Grimberg, Thomas LaFramboise
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139253 (2015)
Recent advances in sequencing technology allow for accurate detection of mitochondrial sequence variants, even those in low abundance at heteroplasmic sites. Considerable sequencing cost savings can be achieved by enriching samples for mitochondrial
Externí odkaz:
https://doaj.org/article/4b04031480914c42ab232d1b6a6ba343
Autor:
Sneha Grandhi, Rajesh Viswanathan, Md. Faiz Ahmad, Andrew J. Knappenberger, Michael E. Harris, Reena Sheth
Publikováno v:
Journal of Biological Chemistry. 292:16463-16476
Eukaryotic class I ribonucleotide reductases (RRs) generate deoxyribonucleotides for DNA synthesis. Binding of dNTP effectors is coupled to the formation of active dimers and induces conformational changes in a short loop (loop 2) to regulate RR spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a4973de530d6ad315b290ff2521288
https://doi.org/10.1074/jbc.m117.798769
https://doi.org/10.1074/jbc.m117.798769
Autor:
Sneha Grandhi, Jerry E. Chipuk, Thomas LaFramboise, M D'Aurello, Janine H. Santos, Doris Germain, Luena Papa, Marcelo G. Bonini, Abdul Kader Sagar, Peter C. Hart, Giovanni Manfredi, M Sersinghe, Timothy C. Kenny, M Ragazzi, Kevin W. Eliceiri, Amanjot Kaur Riar
Publikováno v:
Oncogene
By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588b08d4ddbd0d5d34eb894d31044498
https://doi.org/10.1038/onc.2017.52
https://doi.org/10.1038/onc.2017.52
Publikováno v:
Mitochondrion. 46
Mitochondrial sequence variants have been associated with many human diseases, including cancer. A well-established experimental strategy to assess the impact of mitochondrial sequence variants is to generate cytoplasmic hybrids (cybrids). Cybridizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eab45cbd1d36b171efaf9e2da62921a
https://pubmed.ncbi.nlm.nih.gov/30075297
https://pubmed.ncbi.nlm.nih.gov/30075297
Autor:
Wesley J. Maddox, Colleen M. Bosworth, Sneha Grandhi, Thomas LaFramboise, Ying Ni, Sara Akhavanfard, Cole Sensiba
Although mitochondrial genomes (mtDNA) accumulate elevated levels of mutations in cancer cells, the origin and functional impact of these mutations remain controversial. Here, we queried whole-genome sequence data from 1,916 patients across 24 cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a90bc1bacc8aa2f3cef17ca51c2ca9
https://europepmc.org/articles/PMC5886292/
https://europepmc.org/articles/PMC5886292/
Autor:
Sarah McMahon, Meetha P. Gould, Thomas LaFramboise, Sneha Grandhi, Colleen M. Bosworth, Brian T. Grimerg
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139253 (2015)
PLoS ONE
PLoS ONE
Recent advances in sequencing technology allow for accurate detection of mitochondrial sequence variants, even those in low abundance at heteroplasmic sites. Considerable sequencing cost savings can be achieved by enriching samples for mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9417912d220561d58e79c69ef96d850
http://europepmc.org/articles/PMC4619561?pdf=render
http://europepmc.org/articles/PMC4619561?pdf=render
Autor:
Meetha P. Gould, Colleen M. Bosworth, Sarah McMahon, Sneha Grandhi, Brian T. Grimberg, Thomas LaFramboise
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0156884 (2016)
PLoS ONE, Vol 11, Iss 5, p e0156884 (2016)
Recent advances in sequencing technology allow for accurate detection of mitochondrial sequence variants, even those in low abundance at heteroplasmic sites. Considerable sequencing cost savings can be achieved by enriching samples for mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7a9a5d8951adbdd9cdbc818d7f4687
https://doi.org/10.1371/journal.pone.0156884
https://doi.org/10.1371/journal.pone.0156884